This study was undertaken to observe the mutagenic occurrence in urine excreted after the ingestion of roast beef. Two healthy nonsmoker persons of both sex were selected for this test, employing two strains (TA98, TA100) of Salmonella typhimurium according to Ames' method. The mutagenic activity began to appear in urine of both sex three hours after ingestion of 300 g of roast beef, gradually increasing until 6 hours and declining thereafter.
Eating* ; Humans* ; Methods ; Red Meat* ; Salmonella typhimurium

PURPOSE: The purpose of this study was to identify predictors of depression and quality of life among older adults with osteoarthritis. The predictors included in the model were the client's characteristics(age, pain, disease duration, ADLs), personal resources(hardiness, self-care agency and family support), and depression. METHOD: 150 subjects who were older than 65 years and had diagnosis of osteoarthritis participated in the study. To answer the research questions, descriptive analysis, Pearson correlation, and hierarchical multiple regression were utilized using SPSS WIN program. RESULT: Older adults who were younger and had lower levels of pain and dependency on ADLs, and higher levels of self care agency and hardiness reported lower levels of depression(R2=0.517). Older adults who had lower levels of depression, pain, and dependency on ADLs, higher levels of family support and hardiness, and who are younger reported higher levels of quality of life(R2=0.804). CONCLUSION: Based on the findings of this study, development of nursing intervention program including pain reduction, enhancing ADL abilities and personal resources (hardiness, family support) can be suggested. Further study is needed to increase the ability of generalization of the study findings to the broader population.
Activities of Daily Living ; Adult* ; Depression* ; Diagnosis ; Generalization (Psychology) ; Humans ; Nursing ; Osteoarthritis* ; Quality of Life* ; Self Care ; Surveys and Questionnaires

PURPOSE: This study was done to identify the effects of weight-bearing exercise(WBE) on bone metabolism. METHOD: WBE was performed for 12 weeks by healthy college women. Bone-related parameters were measured four times during this period by evaluating the immunoradiometric assay and enzyme immunoassay. Bone mineral densities(BMDs) were measured by dual energy x-ray absorptiometry before and after the WBE program. Data was analyzed using t-test, paired t-test, x2-test, and repeated measures ANOVA. RESULT: Osteocalcin, a bone formation marker, increased more in the experimental group than in the control group based on the interaction between time and group(F=3.29 p=.024). Little difference between the two groups was found for the other parameters: urinary deoxypyridinoline, insulin-like growth factorI, parathormone, serum calcium, and serum phosphorus without showing any time interaction between the groups. The femoral trochanter BMD rose in the experimental group while that of the control group fell, showing a significant difference for BMD(t=3.06 p=.005). However, there was no significant difference between the two groups for changes in BMD of the forearm, lumbar spine, femoral neck, and femoral ward's triangle. CONCLUSION: These findings supported the WBE is beneficial for increasing bone formation in college women and long-term application is needed to substantiate the effects of WBE as a intervention in promotion of bone-health.
Absorptiometry, Photon ; Adult ; *Bone Density ; *Exercise ; Female ; Humans ; Osteocalcin/blood

PURPOSE: The purpose of this study was to identify the effects of self-efficacy promoting program on self-efficacy, self-care, and anxiety in cancer patients receiving chemotherapy. METHOD: A quasi-experimental nonequivalent control group pre and post design was used. Subjects were 52 cancer patients who received chemotherapy in a hospital. Twenty-six patients were assigned to the experimental and the control groups, respectively. For the experimental group, the CD image for fifteen minutes and two consultations for about ten minutes each were applied. For the control group, ordinary hospital care was applied. The data was collected before and 2 weeks after chemotherapy. RESULT: The scores of self-efficacy and self-care of the experimental group was higher than those of the control group while the state of anxiety of the experimental group was not lower than that of the control group at posttest. CONCLUSION: The self-efficacy promoting program about prevention of infection and hemorrhage increased cancer patients' self-efficacy and self-care but did not decrease anxiety. Further study is needed to find other factors to decrease anxiety and nurses need to consider the concept of self-efficacy in cancer patients receiving chemotherapy when they plan to increase cancer patients' self-care.
Anxiety* ; Drug Therapy ; Hemorrhage ; Humans ; Referral and Consultation ; Self Care*

No abstract available.
Female ; Ovary* ; Teratoma*

PURPOSE: To establish normal reference ranges of urinary flow rate related to age, body surface area and voided volume in normal Korean pediatric females, uroflowmetry was performed and analyzed statistically. MATERIALS AND METHODS: Uroflowmetry was performed on total 270 normal pediatric females who ranged in age from 4 to 12 years(mean+/-SD: 7.23+/-1.97 years). The height and weight were measured then body surface area was calculated by Mosteller`s formula. The uroflow data(peak and average flow) were grouped by age(4 to 6, 7 to 9 and 10 to 12 years old) and body surface area( 1.1 and<1.1 m2) then plotted in volume-related nomograms. RESULTS: Mean values of peak and average flow rates were 13.33+/-4.44 & 7.51+/-2.6, 14.01+/-5.22 & 7.76+/-3.15, 20.40+/-6.84 & 10.89+/-3.97 ml/sec in each age group, and 13.57+/-4.87 & 7.61+/-2.96, 20.14+/-6.44 & 10.65+/-3.79 ml/sec in each body surface area group, respectively. Flow rates were increased significantly with voided volume, age and body surface area. Body surface area was found to be a more reliable index than age in the establishment of nomograms(p<0.05). CONCLUSIONS: Nomograms of peak and average flow rates of normal Korean pediatric female were presented. These may be useful for diagnosing lower urinary tract disturbances in pediatric female over a wide range of age, body size and voided volumes.
Body Size ; Body Surface Area ; Female* ; Humans ; Nomograms* ; Pediatrics ; Reference Values ; Urinary Tract

No abstract available.
Hamartoma*

The aim of the present study was to investigate the mRNA expression of several cytokines which were not reported previously from interface tissues around loose cemented acetabulum to obtain better understanding of the biological mechanisms connected with aseptic loosening and osteolysis of THA. We investigated mRNA expression for several cytokines (interleukin-1 alpha [IL-l~a], IL-lp, IL-2, IL-2 receptor[2R], IL-4, IL-5, IL-8, IL-10, transforming growth factor-beta [TGF-p], and interferon- gamma [IFN-y]) by reverse transcription-polymerase chain reaction (RT-PCR) and release of metalloproteinase (MMP)-2 and MMP-9 from the cement-bone interface tissues around five loose polyethylene acetabular components. We did not include TNF-a and IL-6 because the biologic effect of the former is so similar to that of IL-1, and the latter fails to stimulate prostaglandin E, or collagenase production by fibroblsts or synovial cells. Expression of mRNA for IL-1p was detected in four, IL-2R and IL-8 in three, IL-10 and TGF-p in two of five interface tissues .No expression of mRNA for IL-la, IL-2, IL-4, IL-5, and IFN-p was detected. Zymographic analysis for gelatinase/type IV collagenase revealed gelatinolytic bands corresponding to metalloproteinase(MMP)-2 and MMP-9 in cemenl-bone interface tissues. Activated cells phagocytose particles in cement-bone interface tissues expressed more cytokines mRNA than previously known to be related to periprosthetic bone resorption, and secreted metalloproteinases associated with extracellular matrix degradation and fibrosis.
Acetabulum ; Arthroplasty, Replacement, Hip* ; Bone Resorption ; Collagenases ; Cytokines* ; Extracellular Matrix ; Fibrosis ; Interleukin-1 ; Interleukin-10 ; Interleukin-2 ; Interleukin-4 ; Interleukin-5 ; Interleukin-6 ; Interleukin-8 ; Metalloproteases* ; Osteolysis ; Polyethylene ; RNA, Messenger*

Double elevator palsy (DEP) is an unusual anomaly of ocular motility in which both elevator muscles of the same eye are weak with a resultant inability or reduced ability to elevate the eye and hypotropia. This anomaly is occured congenitally, but occasionally occured as an acquired form. Congenital DEP, which is main cause of the monocular elevation paralysis, is characterized by the progressive deterioration and the absence of diplopia. The etiology is obscure, but is thought to be supranuclear lesion. We observed DEP of the same side of eyes in two patients who were brothers. The limitation of elevation and hypotropia were improved after Knapp's transposition procedure or Jensen's procedure.
Diplopia ; Elevators and Escalators* ; Humans ; Muscles ; Paralysis* ; Siblings*

We measured the axial length according to age in the eyeball of premature infants who were born at our hospital. Our patients were 36 weeks old below in conceptual age, 38 eyes in 19 males, 28 eyes in 14 females. total 66 eyes in 33 premature infants. And we examined the axial length using the A-mode of the LTZ/SSW-48. 7MHz for 1 month at each weeks. The results were as follows: 1. The mean axial length was 16.56mm (15.40-17.80) at 1st week of life. 16.82mm (15.43-17.95) at 2nd week, 17.01mm(15.71-18.01) at 3rd week, 17.04mm (15.72-18.24) at 4th week. 2. The mean axial length of 1st week was 16.77mm in male, 16.34mm in female; at 2nd week, 16.91mm in male, 16.72mm in female; at 3rd week, 17.09mm in male, 16.90mm in female; at 4th week, 17.12mm in male, 16.96mm in female and they did not show significant difference between male and female premature infants.
Biometry* ; Female ; Humans ; Infant, Newborn ; Infant, Premature* ; Male ; Ultrasonics*