1.A case of Distal Renal Tubular Acidosis.
Seong Gyoo PARK ; Gyung Min ANN ; Sang Hee PARK ; Kwang Chul LEE ; Chang Sung SON ; Pyung Hwa CHOI
Journal of the Korean Pediatric Society 1990;33(4):539-543
No abstract available.
Acidosis, Renal Tubular*
2.Correlation of Immunohistochemical Expression of MDR1, MRP1, Topoisomerase IIalpha with Prognostic Factors and Histoculture Drug Response Assay (HDRA) Result in Breast Carcinoma.
Hee Joon KANG ; Sung Hee HONG ; Byung Ho SON ; Ho Sung YOON ; Gyung Yub GONG ; Sei Hyun AHN
Journal of Korean Breast Cancer Society 2004;7(4):228-235
PURPOSE: Drug resistance plays an important role in the failure of chemotherapy in breast cancer. The purpose of the study was to investigate the chemosensitive and chemoresistance indices of breast carcinomas and see if the in vitro chemosensitivity test correlated with the prognostic indices. METHODS: The immunohistochemical expressions of MDR1, MRP1 and topoisomerase IIalpha(topo IIalpha) were studied and then correlated these with the in vitro chemosensitivities using the histoculture drug response assay (HDRA) and clinicopathological factors in 51 breast carcinomas. RESULTS: In the breast carcinomas examined, the immunohistochemical expressions of MDR1, MRP1 and topo II alpha were strongly observed in 26 (51.0%), 16 (32.0%), 15 (31.3%) carcinomas, respectively. The MRP1 was more frequently expressed in poorly differentiated carcinomas (P= 0.006), and those of MDR1 and topo II alpha were more frequently observed in tumor overexpressing cerbB2 (P=0.038, P=0.036). The expression of MDR1 was related to that of topo II alpha (P=0.015). Comparing these markers with the in vitro chemosensitivities to cyclophosphamide, 5-FU, adriamycin, taxol and taxotere, no correlations were found between the expression of MDR1, MRP1, and topo II alpha but from the chemosensitivity using the HDRA, the growth inhibition rate for cyclophosphamide was higher in MRP1 expressing carcinomas (P=0.009). CONCLUSION: MDR1, MRP1 and topo II alpha were all found to be associated with the poor prognostic indices, but assessment of their immunohistochemical expressions did not allow for prediction of the response to chemotherapy by the in vitro chemosensitivity test in breast carcinomas.
Breast Neoplasms*
;
Breast*
;
Cyclophosphamide
;
Doxorubicin
;
Drug Resistance
;
Drug Therapy
;
Fluorouracil
;
Paclitaxel
3.Percutaneous alcohol sclerotherapy for symptomatic congenital cysts.
Chong Soo KIM ; Gyung Ho CHUNG ; Sang Young LEE ; Jeung Min LEE ; Myung Hee SON ; Ho Young SONG ; Ki Chul CHOI
Journal of the Korean Radiological Society 1992;28(1):29-35
Twenty patients with symptomatic congenital cysts in the liver, kidney, thyroid, and lower neck underwent, ultrasound guided percutaneous aspiration through a drainage catheter with temporary instillation of 95% ethanol into the cyst. Our procedure was based on the method as described by Bean and Rodan(16) in 1985. Additionaly, two othe steps were odded to prevent the dilutional effect of residual cyst fluid. One was the preliminary washing of the cyst with alcohol. The other was to treat with 30% replacement of alcohol every 10 minutes during the treatment secession. Minot complications of transient temperature elevation and hziness occurred, butj no major complications were encountered. After the alcohol treatment follow up examinations were performed with computed tomography or ultrasonography at 6 weeks. 6 months. 9 months and 15 months. Although there was diminished size, recurrence was noted in 6 of twenty patients(30%) at 6 weeks and one of twenty patients(5%) at 6 months. There was no recurrence at 9 months and 15 months. The results indicated that percutaneous aspiration and alcohol sclerotherapy are safe and effective therapy for symptomatic congenital cysts.
Catheters
;
Cyst Fluid
;
Drainage
;
Ethanol
;
Follow-Up Studies
;
Humans
;
Kidney
;
Liver
;
Methods
;
Neck
;
Recurrence
;
Sclerotherapy*
;
Thyroid Gland
;
Ultrasonography
4.An experimental study of gallbladder sclerosis with 10% phenol in rabbits.
Chong Soo KIM ; Gyung Ho CHONG ; Sang Young LEE ; Myung Hee SON ; Ki Chul CHOI ; Jung Ku JO ; Baik Hwan CHO ; Dong Geun LEE
Journal of the Korean Radiological Society 1992;28(4):490-496
To evaluate a new reliable sclerosant of the gallbladder, we attempted gallbladder ablation with 10% phenol, and the results compared with those from using 95% ethanol which had been used previousy as gallbladder sclerosing agent in laboratory animals in other reports. After laparotomy, ligation of the cystic dusts with silk and cannulation of gallbladder with 18 gauge angiocatheter were done. Then, transcatheter administration of two different scleroing agents was performed in 8 rabbits respectively and normal saline in four rabbits as a control. Additionally, preliminary washing with each agent were implemented to prevent the dilutional effect of residual bile and bleeding. All animals survived without complication. Eight animals were used for each agent, four each being sacrified two weeks and six weeks after adminstration of sclerosing agents respectively. In our results, 10% phenol was more effective than 95% ethanol in denuding the gallbladder epithelium and promoting fibrosis of gallbladder wall, And it was relatively safe in regard to the dilutional effect of residual fluid and bleeding during procedure. Toxic effects on the liver evaluated by examination of histologic specimen were non-specific except for edematous swelling on some cases, which had also been observed on others including control group. 10% phenol can be considered to be a promosing sclerosant for gallbladder ablation, but further study of its toxicity is needed before its application on human gallbladder.
Animals
;
Animals, Laboratory
;
Bile
;
Catheterization
;
Dust
;
Epithelium
;
Ethanol
;
Fibrosis
;
Gallbladder*
;
Hemorrhage
;
Humans
;
Laparotomy
;
Ligation
;
Liver
;
Phenol*
;
Rabbits*
;
Sclerosing Solutions
;
Sclerosis*
;
Silk
5.The Optimal Conditions of Chromosomal Analysis in Peripheral Blood.
Hee Gyung SON ; Young Il LEE ; Byung Joon JUNG ; Sang Hoon LEE ; Soon Ja KANG
Korean Journal of Obstetrics and Gynecology 2001;44(1):5-16
OBJECTIVE: To find out the optimal conditions of human chromosomal analysis protocol in peripheral blood sample. METHODS: The experiments were made with the variations of phytohaemagglutinin, colcemid, ethidium bromide concentration and the variations of hypotonic solution exposure time. RESULTS: In the experiment on the optimal phytohaemagglutinin concentration, the highest mitotic index in the overall collected cells was obtained in phytohaemagglutinin concentration 15microL/ml. In the experiment on the concentration of mitotic arrestant colcemid, the proper chromosomal state that is meta phase stage and doesn't have many chromosomal crossings or tangles was obtained in colcemid concentration 0.05microg/ml. In the experiment on the optimal exposure time of hypotonic solution(0.075M KCl) treatment, the most suitable intervals between chromosomes were subtained in 20 minutes. In the experiment on the optimal concentration of ethidium bromide to obtain minute chromosomal bands, the best result was when ethidium bromide concentration 5microg/ml or 7.5microg/ml was addition to colcemid concentration 0.02microg/ml. CONCLUSION: The combination of phytohaemagglutinin 15microL/ml, colcemid 0.05microg/ml, hypotonic solution exposure time for 20 minutes is important to the collection of appropriate chromosome state in human chromosomal analysis using peripheral blood. In the case that needs to obtain minute bands, the elongated chromosomes are obtained when ethidium bromide 5microg/ml or 7.5microg/ml in addition to colcemid concentration 0.02microg/ml with the same conditions of phytohaemagglutinin and hypotonic solution.
Demecolcine
;
Ethidium
;
Humans
;
Mitotic Index
6.Lingual Squamous Cell Carcinoma Surrounded by Granular Cell Tumor
Hee Young SON ; Jin Pyeong KIM ; Gyung Hyuck KO ; Eun Jae LEE ; Seung Hoon WOO
Chonnam Medical Journal 2012;48(1):65-68
The granular cell tumor (GCT) is an uncommon, benign lesion with a preference for subcutaneous sites. In the head and neck, the tongue is the most common site, followed by the larynx. We experienced a case of a 27-year-old woman with lingual squamous cell carcinoma (SCC) surrounded by GCT. The pathological findings established that the lesion was SCC covered by GCT in the midline of the tongue. The size of the mass was very small, however, so we excised it in a diamond shape. There is an interesting association between GCTs and other malignant neoplasms. However, no causal relationship between GCT and these other carcinomas has been established. Here we report on an SCC coexisting with GCT at the same site as a median tongue lesion and review the literature.
Adult
;
Carcinoma, Squamous Cell
;
Diamond
;
Female
;
Granular Cell Tumor
;
Head
;
Humans
;
Larynx
;
Neck
;
Tongue
7.Research Trend Analysis of Research Published in the Journal of Dental Hygiene Science from 2011 to 2020
Sun-Mi LEE ; Mi-Gyung SEONG ; Hee-Jung MOON ; Jung-Hui SON
Journal of Dental Hygiene Science 2022;22(3):131-138
Background:
The purpose of this study was to analyze research trends in articles published in the Journal of Dental Hygiene Science over the past decade.
Methods:
From 2011 to 2020, 653 studies were reviewed using a keyword analysis. Contents such as academic classification, research type, research method, research topic, data collection method, data analysis method, and financial support were analyzed.
Results:
Analysis by school type showed 34.2% of clinical dental hygiene studies, 23.3% of educational dental hygiene studies, 22.8% of basic dental hygiene studies, 10.0% of other field studies, and 9.8% of social dental hygiene studies. By type of study, quantitative studies were the most common at 69.5%. Regarding data collection methods, 45.8% of the studies that used surveys were the most common. The subjects of the study were 20.1% experimental studies, 15.6% general adults, and 15.0% dental hygienists. Regarding the data analysis method, 49.3% of the studies that conducted frequency analysis were the most common. The total number of keywords was 2,390, with 107 (4.48%) being ‘dental hygienists.’ Next, oral health was the most common with 67 (2.80%) articles, followed by 31 for the elderly (1.30%), 25 for dental hygiene students (1.05%), and 24 for stress (1.00%).
Conclusion
For academic development of dental hygiene, it is necessary to explore the diversity of academic topics based on the results of this study. It is necessary to find a way to spread the research results so that the published research can be used for the academic development of dental hygiene.
8.Validation of Korean Version of Low Anterior Resection Syndrome Score Questionnaire
Chang Woo KIM ; Woon Kyung JEONG ; Gyung Mo SON ; Ik Yong KIM ; Ji Won PARK ; Seung-Yong JEONG ; Kyu Joo PARK ; Suk-Hwan LEE
Annals of Coloproctology 2020;36(2):83-87
Purpose:
Patients who undergo radical surgery for rectal cancer often experience low anterior resection syndrome (LARS). Symptoms of this syndrome include frequent bowel movements, gas incontinence, fecal incontinence, fragmentation, and urgency. The aim of this study was to investigate the convergent validity, discriminative validity, and reliability of the Korean version of the LARS score questionnaire.
Methods:
The English LARS score questionnaire was translated into Korean using the forward-and-back translation method. A total of 146 patients who underwent radical surgery for rectal cancer answered the Korean version of the LARS score questionnaire including an anchor question assessing the impact of bowel function. Participants answered the questionnaire once more after 2 weeks.
Results:
The Korean LARS score questionnaire showed high convergent validity in terms of high correlation between the LARS score and quality of life (perfect fit 55.5% vs. moderate fit 37.6% vs. no fit 6.8%, respectively; P < 0.001). The LARS score also showed good discriminative validity between groups of patients differing by sex (29 for males vs. 25 for females; P = 0.014), tumor level (29 for ≤8 cm vs. 24 for >8 cm; P = 0.021), and radiotherapy (32 for yes vs. 24 for no; P = 0.001). The LARS score also demonstrated high reliability at test-retest with no difference between scores at the first and second tests (intraclass correlation coefficient: Q1 = 0.932; Q2 = 0.909, Q3 = 0.944, Q4 = 0.931, and Q5 = 0.942; P < 0.001, respectively).
Conclusion
The Korean version of the LARS score questionnaire has proven to be a valid and reliable tool for measuring LARS in Korean patients with rectal cancer.
9.Comparison of Inofoam(R) and Medifoam(R) for Donor Site Dressing after Split Thickness Skin Graft in Burn Patients.
Yong Hoon SON ; Young Ho JANG ; Hyun Dong CHAE ; Im Hee SHIN ; Sang Gyung KIM ; Mi Young LEE
Journal of Korean Burn Society 2012;15(1):20-23
PURPOSE: Inofoam(R) is a hydrocellular material developed recently for wound dressing. In the present study, the efficacy of Inofoam(R) for donor site dressing after split thickness skin graft (STSG) was evaluated and compared with that of Medifoam(R). METHODS: The study was conducted on 15 patients with third degree of burn underwent STSG from Nov. 2011 to Feb. 2012. Donor sites were divided into groups of Inofoam(R) and Medifoam(R). The duration of wound healing, pain score and exudate absorption ratio were compared between the two groups. RESULTS: The duration of wound healing time was 10.7+/-2.2 days in Inofoam(R) group, 10.5+/-2.0 days in Medifoam(R) group (P>0.05). On postoperative 1 day, the exudate absorption ratio in was 341.6+/-59.3% in Inofoam(R) group and 349.0+/-41.8% in Medifoam(R) group. There were no significant differences in wound healing duration, swelling ratio, and pain score between the two groups (P>0.05). CONCLUSION: The present study shows that the efficacy of a recently used polyurethane foam Inofoam(R) for donor site dressing is as effective as that of Medifoam(R).
Absorption
;
Bandages
;
Burns
;
Exudates and Transudates
;
Humans
;
Polyurethanes
;
Skin
;
Tissue Donors
;
Transplants
;
Wound Healing
10.Preoperative Oral Carbohydrate Loading in Pancreaticoduodenectomy.
Kum Hee SON ; So Young KIM ; Yeong Ah CHO ; Gyung Ah WIE ; Sung Sik HAN ; Sang Jae PARK
Clinical Nutrition Research 2016;5(3):213-218
Overnight fasting before elective surgery has been the routine to reduce the risk of pulmonary aspiration. Recently, several international guidelines for preoperative fasting recommend to intake carbohydrate-containing fluids up to 2 to 3 hours before the induction of anesthesia to improve postoperative recovery. Based on the recommendations, we developed a "preoperative carbohydrate diet" provided for the preoperative patients. The purpose of this case report is to share our experience of applying preoperative carbohydrate loading prior to surgery.
Anesthesia
;
Fasting
;
Humans
;
Insulin Resistance
;
Pancreaticoduodenectomy*