1.Clinical Observation of Neonatal Skin.
Kyu Han KIM ; Hee Chul EUN ; Chong Ku YUN
Journal of the Korean Pediatric Society 1984;27(11):1063-1069
No abstract available.
Skin*
2.Repair of Chromate induced DNA-Protein Crosslinks in Rat Lymphocyte.
Hun Jae LEE ; Kwan Hee LEE ; Yun Chul HONG
Korean Journal of Preventive Medicine 1996;29(3):597-608
Genotoxic agents can induce various DNA lesions. DNA-Protein Crosslinks(DPCs) were known as the important DNA lesions which could impair gene expression because DPCs had a high probability of resisting repair and persisting through cell cycle. This repair resistance of DPCs could have biological significance but had not been evaluated clearly yet. Most of the studies that have evaluated the repair of DPCs only compared the extent of DPCs repair with other DNA lesions. We injected K2CrO4, a genotoxic agent, into Sprague-Dawley rats intraperitoneally(5mg/kg) and isolated blood lymphocytes 12 hours later. These lymphocytes were cultured in the mitogen added growth media and mitogen free media separately. The degree of the repair of DPCs was monitored for 4 days by the K-SDS assay. 4 day later, the amount of DPCs decreased by 4.6% in the mitogen added media but in creased by 10.9% in the mitogen free media. These results showed that DPCs induced by K2CrO4 were not repaired easily and the DPCs were biologically significant DNA lesions. We thought the decrease of DPCs in the mitogen added media was not due to the repair of DPCs, but from the increase of normal cell proliferation. Therefore, it is very important to consider the proliferation of normal cells when estimating the repair of DPCs.
Animals
;
Cell Cycle
;
Cell Proliferation
;
DNA
;
Gene Expression
;
Lymphocytes*
;
Rats*
;
Rats, Sprague-Dawley
3.The Risk Factors of Industrial Low Back Pain among Shipyard Workers.
Yun Chul HONG ; Eun Hee HA ; Hye Sook PARK
Korean Journal of Preventive Medicine 1996;29(1):91-102
Low back pain patients an controls of shipyard workers were surveyed between June 1995 and september 1995 to identify risk factors of industrial low back pain. The patients were 17 male workers who had got medical treatment for over 3 days because of industrial back pain controls were 51 male workers who had not have musculoskeletal disorder for one year before the survey. By univariate analysis, the workers who did overtime work 4 times or more for the last 2 weeks showed odds ratio of 3.67 on low back pain with the workers who did less overtime work. Carrying heavy materials was also associated with the low back pain and the odds ratio increased with the increase of carrying weight. work space and work posture were not associated with the low back pain significantly. The welder had higher odds ratio than the other workers on low back pain. The duration of employment and job satisfaction did not affect the risk of low back pain. Multiple logistic regression analysis showed that frequency of overtime work for the last 2 weeks and carrying heavy materials among the risk factors were associated significantly with the low back pain. We found that important risk factors of low back pain of shipyard workers are work intensity factors such as overtime work and carrying heavy weight.
Back Pain
;
Employment
;
Humans
;
Job Satisfaction
;
Logistic Models
;
Low Back Pain*
;
Male
;
Odds Ratio
;
Posture
;
Risk Factors*
4.Haemagglutination inhibition antibodies of Japanese encephalitis virus to bats, Korea.
Yun Tai LEE ; Jae Ong SONG ; Chul Hee PARK
Journal of the Korean Society of Virology 1991;21(2):173-178
No abstract available.
Antibodies*
;
Asian Continental Ancestry Group*
;
Chiroptera*
;
Encephalitis Virus, Japanese*
;
Encephalitis, Japanese*
;
Humans
;
Korea*
5.Combined Treatment with Metallic Stent Placement and Radiotherapy in Malignant Biliary Obstruction.
Chul Yong KIM ; Yun Hwan KIM ; Taek Soo RHO ; Chang Hee LEE ; Hoe Seok JUNG
Journal of the Korean Radiological Society 1994;31(6):1045-1049
PURPOSE: To evaluate the efficacy of combined treatment of metallic biliary stent placement and radiotherapy in malignant biliary obstruction. MATERIALS AND METHODS: Between January 1992 and February 1994, 22 patients with malignant biliary obstruction were treated with metallic biliary stent placement and radiotherapy. The causes of the obstruction included cholangiocarcinoma(n=14), gallbladder carcinoma(n=4), colon cancer(n=2), pancreatic head cancer (n=1), and stomach cancer(n=1). According to the sites of obstruction level, patient were divided into 2 groups; hilar obstruction(n=18) and common bile duct obstruction(n=4). The patients received dose of 45 Gray/18 fraction by external radiotherapy and 20Gy/8f by high dose rate brachytherapy with iridium--192 source through percutaneous transhepatic biliary drainage(PTBD) catheter. The duration of stent patency after placement, survival period and survival rate by Kaplan Meier method were calculated in dead and alive patients, respectively. RESULTS: In all 22 patients, the duration of stent patency was 5.5(1.3--18.5)months. Survival periods after stent placement and PTBD were 5.3(2.0--8.5 )months and 7.9(4.0--14.7)months respectively in 9 dead patients and 7.7(1.3--21.0)months and 9.5(2.3--23.0)months in 13 alive patients. In all 22 patients, the survival rates in 6, 12 and 18 months were 78.9%, 47.5 % and 35.6 %, respectively. CONCLUSIONS: The results with combined metallic biliary stent placement and radiotherapy for the palliative treatment of malignant biliary obstruction in this study was more favorable, as compared with those of the other authors with only metallic biliary stent placement.
Brachytherapy
;
Catheters
;
Colon
;
Common Bile Duct
;
Gallbladder
;
Head and Neck Neoplasms
;
Humans
;
Palliative Care
;
Radiotherapy*
;
Stents*
;
Stomach
;
Survival Rate
6.The effect of craterellus aureus extracts to proliferation ofsarcoma-180 cells.
Mi Kyung CHO ; Kyu Sun JUNG ; Chul Hee PARK ; Yun Tai LEE
Korean Journal of Immunology 1991;13(2):215-224
No abstract available.
7.Studies on the antibody distribytion against the etiological virus of hemorrhagic fever with renal syndrome to bats in Korea.
Yun Tai LEE ; Chul Hee PARK ; Kyu Bong CHO ; Eun Byoung PARK
Journal of the Korean Society of Virology 1993;23(2):131-139
No abstract available.
Chiroptera*
;
Hemorrhagic Fever with Renal Syndrome*
;
Korea*
8.The Influence of the Amount of Mandibular Advancement in the Application of Mandibular Advancement Device for Obstructive Sleep Apnea Patients.
Young Kyun KIM ; In Young YOON ; Jeong Whun KIM ; Chul Hee LEE ; Pil Young YUN
Sleep Medicine and Psychophysiology 2011;18(1):29-34
OBJECTIVES: The purposes of this study were to estimate the effect of mandibular advancement device (MAD) and to evaluate the influence of the advancement amount of mandible in the application of MAD for obstructive sleep apnea (OSA) patients. METHODS: From the patients who were diagnosed as OSA by polysomnographic study at Seoul National University Bundang Hospital from January 2007 to February 2009, the patients who chose MAD as treatment option were included in this study. All the patients' data including clinical records and polysomnographic studies (both pre- and post-treatment) were reviewed and analyzed. RESULTS: Successful results were obtained in 65 patients of 86 patients (75.6%). In the follow-up period, mild discomfort of anterior teeth or temporomandibular joint (TMJ) were described in 28 patients, especially in the cases the amount of mandibular advancement were more than 7.0 mm. There was no direct relationship between the amount of mandibular advancement and clinical outcome. CONCLUSION: MAD was effective treatment option for the OSA patients regardless of severity. For the prevention of potential dental complications, the amount of mandibular advancement should be considered at the time of MAD treatment.
Adenine Nucleotides
;
Follow-Up Studies
;
Humans
;
Mandible
;
Mandibular Advancement
;
Mycophenolic Acid
;
Sleep Apnea, Obstructive
;
Temporomandibular Joint
;
Tooth
9.A Survey of Working Conditions of Migrant Workers.
Korean Journal of Occupational and Environmental Medicine 1996;8(1):1-14
The number of migrant workers staying in Korea is 73,250 August 1994 now by the data which Economic Planning Agency presented to the National Assembly. Industrial trainees were reported to be 17,640 and illegal stayers were 55,610 but many migrant workers did not seem to be included. There are some reports which described the unfulfillment of their basic right such as discrimination of wage, delay of payment, long working hours, enforced work, but working conditions, work environment and their health were not surveyed well. Therefore this survey is to study their situation such as working conditions, work environment, health and living conditions as well as general characteristics. Questionnaire was written by plain English and was made of closed question mainly. Finally 185 persons completed the questionnaire. The results are as follows; 1) The general characteristics are following: ages are mostly between 20 and 29 years old, and males are more than females, and mostly unmarried. Many were students in their countries and their education levels were high. 2) Many persons; were introduced to Korea by native broker. Total cost for coming to Korea was mostly over $1,000 and many paid over $2,000. Their staying period in Korea is mostly over 2 years arid many persons think their status uneasy. The most important purpose for coming to Korea is to earn money. 3) Many are working in garment factories but most factories are small scale: ones below 20 employees. Most are working over 10 hours a day. The average income is $480 and that is about 54.8% of average income of Korean workers. Unpaid salaries are about $921 per each worker. 4) 15.8% of migrant workers answered to have experienced industrial accidents. Their health status seems to be worse after coming to Korea. The resident environment was very poor. We knew that migrant workers' situation was very bad considering their working conditions, work environment, health and living conditions. Therefore, employment policy of migrant workers must be reviewed immediately and good working conditions must be provided to them as soon as possible.
Accidents, Occupational
;
Adult
;
Discrimination (Psychology)
;
Education
;
Employment
;
Female
;
Humans
;
Korea
;
Male
;
Questionnaires
;
Salaries and Fringe Benefits
;
Single Person
;
Social Conditions
;
Transients and Migrants*
10.In Vitro Assessment of Cytotoxicity and Mutagenicity of Rock Wool Fibers.
Korean Journal of Preventive Medicine 1997;30(3):555-566
This study was carried out to evaluate the cytotoxicity of rock wool fibers(RWFs) such as cell division disturbance, chromosomal and DNA damage, and mutagenicity using cultured cells. RWFs were the man made mineral fibers. In order to find the correlation between the cytotoxicity of RWFs and the phagocytic capacity of cells, the phagocytic processes were observed using scanning electron microscope. Cell division disturbance by RWFs was evaluated by the formation of multinucleated giant cells. The chromosomal damage was evaluated by the micronucleus formation. For the evaluation of oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine (8-OH-dG) formation was measured utilizing calf thymus DNA. Mutagenicity was determined by the point mutation of HGPRT and the effect of RWFs on cell transformation was also observed. 1. Compared with the results of chrysotile, RWFs were no or little effect on the cell growth according to the results done by the tests of cell proliferation inhibition and relative plating efficiency. 2. The frequency of multinucleated giant cell formation was increased by the treatment of RWFs and it was dose-dependent. However, the effect of RWFs was weaker than that of chrysotile. 3. The number of micronuclei formed in the RWFs treated cells was between those of cells treated with chrysotile and those of untreated cells. 4. The 2 fold increase in the formation of 8-OH-dG in calf thymus DNA was observed in the cells treated with RWFs in the presence of H2O2. On the other hand, chrysotile had no effect on the 8-OH-dG formation. 5. RWFs had no effect on the HGPRT point mutation and cell transformation. These results showed that RWFs could induce chromosomal damage, cell division disturbance and oxidative DNA damage in the RWFs treated cells.
Asbestos, Serpentine
;
Cell Division
;
Cell Proliferation
;
Cells, Cultured
;
DNA
;
DNA Damage
;
Giant Cells
;
Hand
;
Hypoxanthine Phosphoribosyltransferase
;
Mineral Fibers
;
Point Mutation
;
Thymus Gland
;
Wool*