Although hepatitis B virus is usually transmitted parenterally, many cases of in fection occur in which overt parenteral contact with the virus cannot be shown. Skin is cansidered to be one route of it and there have been a few related reports recently. As Korea is one of the endemic areas of hepatitis B virus infection, I have checked HBsAg,Anti-HBs, Anti-HBc by radioimmunoassay in patients with hand eczerna to confirm other authors recent report which suggested hand skin lesion is one of the risk factors of hepatitis B virus infection. Total 41 patients were included in this study and all patients were female except one. The study results were as follows. The total prevalence rate of HBsAg was 4, 9% which is not significant different from the control. 2 The total prevalence rate kers including HBsAg was control. of the patients showed positive for one or more markers 5g 5%, which was not significant different from the contorl.
Eczema* ; Female ; Hand* ; Hepatitis B Surface Antigens ; Hepatitis B virus* ; Hepatitis B* ; Hepatitis* ; Humans ; Korea ; Prevalence ; Radioimmunoassay ; Risk Factors ; Skin

Translation of terminology into Korean in the field of medicine has been one of the important tasks for the last several decades in Korea. Translation of medical terminology is deeply indebted to the Japanese scholars and direct adaptation of their work by the Korean scholars was the main trend since long time ago. This is because we share Chinese characters and the grammar structure. Although some modification and addition of new translation which is more suitable for the Korean language system has been tried in different aspects in the past editions of English-Korean medical terminology books, extensive works has been performed for the 4th edition which was published by the Korean Medical Association in 2001. The Korean Dermatological Association published the first editon of dermatology terminology book in 1983 and the 2nd edition in 1993. Many of them have been adapted in the 4th edition by the Korean Medical Association. However, many changes are noticed representing new trials with innovative ideas. This special article covers some changes of dermatological terminology between the old and new editions of terminology book published by the Korean Medical Association. Major examples are summarized in several tables.
Asian Continental Ancestry Group ; Dermatology ; Humans ; Korea

Since the foundation of Korean Contact Dermatitis Resear Group in 1980, many reports related to contact dermatitiis have been published. In this articl, 94 Korean references related to epidemiology and clinical aspect of contact dermatitis which have been published for the past 2 decades were reviewcied apers about medicaments were mos 1 equent(53) and, plants and animals(25), occupation(33), cosmetics(23), metals(19) loere in order of frequency. lhe general incidences of contact dermatitis were 5.3% 13.5% in the general out-patients. The main allergens which showed high positive rates in rovin. patch tests were a little different according to the different authors. In common allergens reckel sulfate and cobalt chloride showed increasing tendencies, while ammoniated mercury, first alldehyde, paraphenylene diamine and rubber chemicals showed decreasing tendendies. Potassiun a chromate, neomycin sulfate, and fragrance related allergens which are also commonly encountred showed variable positive rates according to the different authors. In MOHL indices less occuational and few leg ulcer cases have been observed. Obtaining informations are the key point of publication becteria, there have been more aborted studies which were presented at the annual contact dermatit ymposia in Korea, however not published.
Allergens ; Cobalt ; Dermatitis, Contact* ; Epidemiology ; Humans ; Incidence ; Korea* ; Leg Ulcer ; Neomycin ; Outpatients ; Patch Tests ; Publications ; Rubber

Fifty-five patients completed a questionaire to assess disability caused by atopic dermatitis. The eleven most relevant questions were identified and an Atopic Dermatitis Disability Index (ADDI) calculated. The index correlated with the clinical severity score (rs=0.273, 0.01 <0.05). The index may be used as a simple repeatable record of disability caused by atopic dermatitis and may potentially aid management decisions.
Dermatitis, Atopic* ; Humans

We have studied male patients with cosmetic allergy in patch test during 5 years from September, 1982 to August, 1986 (Group A) and during 7 1/2 years from March, 1988 to August, 1995 (Group B). The results are as follows. 1. In Group A, 7 patients were diagnosed as contact allergy due to cosmetics. In Group 13, 30 patients were diagnosed as contact allergy to cosmetics. 2. Sixteen patients were positive to only cosmetic related allergens. Two patients were positive to only their own cosmetic products. Nineteen patients were positive to both cosmetic related allergens and their own cosmetic products. 3. The age of patients with cosmetic allergy ranged from 10 to 70 years with a peak in the fifties. The patients more than 50 years were about 40% of all patients. 4. The most frequently, affected area was face(n=31) followed by neck(n=6) and scalp (n = 6 ). 5. Twenty four patients with cosmetic allergy had eczematous skin lesions. Thirteen patients had pigmented skin lesions and pigmented contact dermatitis was suspected. Two out of 13 patients with pig men ted skin lesions were positive in photopatch test. 6. Cosmetic related allergens showing frequent positive reactions were paraphenylene-aliamine, fragnance mix, balsam of Peru, benzyl salicylate, amerchol L101, oakmoss absolute, musk muskene. 7. Cosmetic products showing frequent positive reactions were skin care products, hair dye, soap, after shave lotion, shampoo and toothpaste. In conclusion, cosmetic allergy in men seems to increase in our society.
Allergens ; Dermatitis, Contact ; Hair ; Humans ; Hypersensitivity* ; Male* ; Patch Tests ; Peru ; Scalp ; Skin ; Skin Care ; Soaps ; Toothpastes

Contact Dermatitis due to cosmetics is also common in Korea. as in other developed countries. However. detection of the causative antigens is in a difficult situation due to many reasons. We have routinely patch tested with Japanese cosmetic series patch test allergens, Types 17 and 18 in addition to Hollister standard battery and patients own cosmetics to 4Q cases of suspected cosmetic contact dermatitis who have visited our Environmental and Occupational Clinic during the past one year. The study result was as follows. Total 55% ositive reaction related to cosmetics was observed in 4p patch tested patients. 2 The most frequently observed antigens were hydroxycitronellal, benzyl saliylate and cinnamic alcohol.
Allergens ; Asian Continental Ancestry Group ; Dermatitis, Contact* ; Developed Countries ; Humans ; Korea ; Patch Tests*

No abstract available.
DNA* ; Polymerase Chain Reaction*

The ability of nicotinic acid and its substitutes to increase cutaneous blood flow has been measured by laser Doppler flowmeter in 30 healthy human volunteers. We applied nicotinarnide, nicotinic acid ethyl ester, nicotinic acid methyl ester, hexyl nicozinate each in an acqeous solution at a concentration of 10 mM/liter for 10 minutes occlusion on the forearm. The change of blood flow was serially checked at 5 to 10 minutes intervals for one hour. The study results were as follows : l. The relative maximum cutaneous blood flow response was in following order nicotinic acid methyl ester(100%), nicotinic acid ethyl ester(98%), hexyl nicotinate (84%) and nicotinic acid(63%). However, there was no statistically significant difference(p>0.05) between each drug. There was statististically significant difference between nicotinamide and all other nicotinic acid substitutes(p<0.05). 2. The time required to reach maximum blood flow response was 6.7 minutes for hexyl nicotinste, 10 minutes for nicotinic acid ethyl ester, 12.5 minutes for nicotinic acid methyl ester and 20 minutes for nicotinic acid. However, there was statistically significant difference between hexyl nicotinate and nicotinic acid only(p<0.05). 3. Significant decrease of cutaneous blood flow was observed one hour after the removal of the patches in all drugs.
Flowmeters ; Forearm ; Healthy Volunteers ; Niacin* ; Niacinamide

No abstract available.
Acantholysis* ; Captopril* ; Penicillamine* ; Rifampin* ; Skin*

BACKGROUND: Factors that regulate hair matrix cell division within the hair follicles and control hair growth cycle have been poorly understood untill now. One of the main.causes seems to be lack of good in vitro models. OBJECTIVE: This study was performed to investigate the hair growth promoting potencies of several agents including individual components of keratinocyte growth media. METHODS: Several agents such as epidermal growth factor, insulin, bovine pituitary extract which were contained in keratinocyte growth media as well as minoxidil and transforming growth factor-α were added to the isolated anagen hair follicles. Measuring the length of hair follicle, thymidine and leucine uptake were used for hair growth parameter. RESULTS: Isolated anagen hair follicles in keratinocyte growth media showed a significant increase in length over 48 hours. [Methyl-³H] thymidine and [U-¹⁴Cl leucine uptake were sustained at basal state as well as over 48 hours and [methyl-³H] thymidine uptake increased in the matrix cells under autoradiography. Insulin with a concentration above 0.5µg/ml and transforming growth factor-α with a concentration above 10ng/ml showed a promoting effect on hair growth. However, other agents did not promote hair growth at all. CONCLUSION: Our in vitro model resembles the in vivo status of hair growth for a limited period of time and we think that normal human hair organ culture may be a useful model for developing hair growth promoting agents in vitro.
Autoradiography ; Cell Division ; Epidermal Growth Factor ; Hair Follicle* ; Hair* ; Humans ; In Vitro Techniques ; Insulin ; Intercellular Signaling Peptides and Proteins* ; Keratinocytes ; Leucine ; Minoxidil ; Organ Culture Techniques* ; Thymidine