No abstract available.

We present a case of eccrine spiradenoma occurring on the trunk in a 33 year old woman. She developed a pea sized, pinkish tender nodule on the anterior chest 8 years ago. On histologic examination, there were several lobules surrounded by thin connective tissue septa in dermis. The lobules themselves consisted of small dark staining cells and large pale-staining cells, forming solid cords or ducts.
Adult ; Connective Tissue ; Dermis ; Female ; Humans ; Peas ; Thorax

Nineteen patients (twenty knees) with degenerative arthritis of knee treated by arthroscopic curettage were reviewed. Of the nineteen patients, there were eighteen females and one male ranging in age from 49 to 68 years (mean, 57 years). The mean follow up period was 18.2 months (range, 12 months to 21 months). Simple standing roentgenorgram and 99m-Tc bone scintigraphy were used to select the patients with medial compartment involvement only, less than 5 degree of varus deformity and sparing of patello-femoral joint. Knee scoring by Hospital for Special Surgery Formula showed improvement from the preoperative average 68 points to postoperative average 89.6 points (21.6 points increase) and 84.1 points (16.1 points increase) at 6 months and one year respectively. Arthroscopic curettage of knee, if done early in degenerative arthritis, not only can shorten hospital days and immobilization period but also can defer other major surgical treatments by promoting natural healing process and symptomatic relief.
Congenital Abnormalities ; Curettage ; Female ; Follow-Up Studies ; Humans ; Immobilization ; Joints ; Knee ; Male ; Osteoarthritis ; Radionuclide Imaging

During tumor progression, a subset of cells acquires metastatic properties, presumably through a series of genetic alterations. As the result, cells detach from the primary tumor, penetrate the basement membrane and invade the adjacent structures including lymph and blood vessels. Loss of adhesive functions and gain of new adhesive functions are thought to play a crucial role in this metastatic cascade. Since tumor metastasis is the principle cause of death for cancer patients including colon cancer, there is a consensus that a search for tools that allow effective assessment of the metastatic potential of tumors is a prime goal for cancer research. An immunohistochemical study of cell adhesion molecules, CD44H and its variant CD44v6, was done to evaluate their relationship with known prognostic factors related to the progression and metastasis of colorectal carcinoma in 94 cases of colorectal carcinoma tissues. The results were as follows. The CD44H expression was detected in 90 (95.7%) and CD44v6 in 53 (56.4%) out of 94 cases of colorectal carcinoma, and the CD44H was overexpressed in tumor tissue more than in normal mucosa in 62% of the cases. The expression rates of both protein were not significantly correlated with age and sex of the patients, invasion depth, lymph node metastasis, tumor differentiation, and tumor site. The coexpression of CD44H and CD44v6 in tumor was significant (p<0.05). The above results suggest that overexpression of CD44H and loss of function to control the alternative splicing of CD44 mRNA resulting in CD44v6 expression and alteration of adhesive function are closely associated with tumorigenesis of the colorectum.
Adhesives ; Alternative Splicing ; Basement Membrane ; Blood Vessels ; Carcinogenesis ; Cause of Death ; Cell Adhesion Molecules* ; Cell Adhesion* ; Colonic Neoplasms ; Colorectal Neoplasms* ; Consensus ; Humans ; Lymph Nodes ; Mucous Membrane ; Neoplasm Metastasis ; Prognosis ; RNA, Messenger

We observed the neonatal skin to investigate the incidence and clinical features of birthrnarks. We examined 1791 newborn babies admitted in the nursery of Kangnam Sacred Heart Hospital from July 1987 to July 1989. The results were summarized as follows. 1. Mongolian spots were observed in 1435 neonates (80.1%), occurring most frequently on the lumbosacral area. 2. Salmon patches were observed in 416 neonates (23.2%), the nape of neck being the most common site. 3. Pigmented lesions were observed in 20 neonates (1.1%). 4. Portwine stains were observed in 15 neonates (0.8%). 5. Epidermal nevi were observed in 4 neonates (0.2%) and nevus sebaceus developed in one baby.
Coloring Agents ; Heart ; Humans ; Incidence ; Infant, Newborn* ; Mongolian Spot ; Neck ; Nevus ; Nurseries ; Salmon ; Skin

No abstract available.
Cyclic GMP* ; Cytomegalovirus* ; Gene Expression* ; Humans*

BACKGROUND: The oncogene, c-fos, is a useful marker of nociceptive neurons activated by various types of pain.However, the relationship between c-fos and acute pain induced by surgical incision has not been studied.The purpose of this study was to describe the expression of spinal c-fos in a rat model of postoperative pain. METHODS: Sprague-Dawley rats were used to enumerate spinal fos-like immunoreactive (fos-LI)-positive neurons after making sham, skin, or skin-muscle incisions on the plantar surface of the rat hindpaw. The spinal cords were divided into the following 4 segments for immunohistochemical detection of fos-LI at 3 time points after the incision (4 hours, POD1, and POD3):thoracic, upper lumbar, lower lumbar, and sacral.For analysis of the laminar distribution of fos-LI, the dorsal horn was divided into three regions (I-II, III-IV, and V-VI). RESULTS: The number of fos-LI was increased in the ipsilateral spinal dorsal horn in the lower lumbar segment 4 hours post-incision and was significantly greater in rats with skin-muscle incisions than in rats with skin-alone incisions.In the skin-muscle group, laminae I-II and V-VI had a greater number of fos-LI neurons than laminae III-IV.The increase in number of spinal fos-LI neurons normalized by POD1 and POD3. CONCLUSIONS: c-fos expression is confined to neurons of the spinal dorsal horn known to be activated by nociceptive stimulation. The larger the injury elicited, the greater the expression of c-fos, suggesting that the expression of c-fos can serve as a useful marker of activated nociceptive neurons caused by acute pain following surgical incision.Further study is required to elucidate why the degree of tissue injury affects the laminar distribution of c-fos expression.
Acute Pain ; Animals ; Horns ; Neurons ; Nociceptors ; Oncogenes ; Pain, Postoperative ; Rats ; Rats, Sprague-Dawley ; Salicylamides ; Skin ; Spinal Cord

BACKGROUND: Scuba diving has become increasingly popular in Korea. Medical problems are common with dives, especially decompression sickness(DCS). This study was performed to obtain an useful information of hyperbaric oxygen therapy in DCS in Korea. METHOD: We reviewed the 62 cases of Korean divers, who were diagnosed as DCS and received recompression therapy according to U.S. Navy Standard Recompression Treatment Table at Ocean and Underwater Medical Research and Training Center of ROK Navy, for 6 years from Jan. 1993 to Nov. 1998. RESULT: 1) the mean no-decompression limit excess time between type I DCS group(72.7 min.) and type II DCS group(92.8min.) showed significant difference. 2) The rate of symptoms appeared on surfacing and within 10min. after surfacing of type I and type II DCS were 41.4%and 72.7% respectively. 3) The cure late of type I and type II were 75.9%and 42.4% respectively. In type II DCS group, the cure rate of the group within 12 hour-delayed recompression treatment and the group above 12 hour-delayed treatment were 64.3%and time 26.3% respectively, and in type I DCS group, 100% and 66.7% respectively. CONCLUSION: These findings suggest that the education of safety, the strict observance of the standard decompression table, and the avoidance of excessive repeated diving are important for reducing the risk of diving related disease. And to offer proper management of DCS, there should be more multiplace hyperbaric oxygen chambers, the suitable transport system, and the specialist of diving medicine or hyperbaric medicine in Korea.
Decompression Sickness* ; Decompression* ; Diving ; Education ; Hyperbaric Oxygenation* ; Korea ; Oxygen ; Specialization

OBJECTIVES: In double-blind controlled studies with schizophrenic patients, risperidone was demonstrated to have an efficacy comparable to haloperidol and to have a lower incidence of extrapyramidal side effects. The purpose of this study was to assess the effect of risperidone in the treatment of schizophrenia and to identify clinical factors associated with risperidone response under naturalistic clinical setting. METHODS: By retrospective chart review, we assessed response to risperidone and factors associated with response to resperidone in 62 consecutive DSM-IV schizophrenic patients treated with the drug at the Department of Psychiatry, Keimyung University Dongsan Medical Center. We divided the 62 patients into two groups, responders and non-responders, by responsiveness to resperidone according to a four-point scale used in previous studies; responders included moderate to marked responded patients and non-responders included none to minimal responded patients. RESULTS: Among the total patients of 62, 31(50%) were categorized as responders. In comparing responders(N=31) with non-responders, there were no differences between the two groups in sex, age, education, age at first onset, duration of illness, number of admissions, and family history, but the patients who were married and had the paranoid-typed symptoms were significantly more frequent in responders. There were no significant differences in dose of risperidone and frequency of extrapyramidal side effects between the two groups. Antipsychotic-naive patients were significantly more frequent in responders(p=0.009). CONCLUSION: These results suggest that marital status and paranoid type of schizophrenic symptoms may be useful as the clinical predictors associated with risperidone response in schizophrenic patients, and that risperidone is an appropriate first-line antipsychotic agent in antipsychotic-naive schizophrenic patients.
Diagnostic and Statistical Manual of Mental Disorders ; Drug Therapy ; Education ; Haloperidol ; Humans ; Incidence ; Marital Status ; Retrospective Studies ; Risperidone* ; Schizophrenia*

No abstract available.