PURPOSE: Purpose of study was to analyze the research articles in the Journal of Korean Oncology Nursing in order to provide an direction for the future research. METHODS: This study analyzed 93 studies published in the Journal of Korean Oncology Nursing, from its beginning year to the year 2007, according to the research objectives. The frame of evaluation included years and types of publication, the theoretical frameworks, research design, subject, data collection method, keyword analysis by MeSH. RESULTS: 45.2% of studies was non-degree based studies. 95.7% of studies was not described theoretical framework in the articles. 71.0% was utilized a non-experimental design. 57% of subjects in researches was patients. 76.3% of studies were used the questionnaire for data collection. Concepts as human, nursing, and health were consistently appeared in research. But concepts of environment has been insufficiently conducted. CONCLUSION: Researches in the Journal of Korean Oncology Nursing has been changed in methodology and the topics of research for the last 7 yr. It progresses in both quantity and quality. But, it is necessary to conduct research founded on theoretical background, various research design, variability of study subjects and topics as supported by scientifically and empirically.
Data Collection ; Humans ; Korea ; Medical Oncology ; Nursing Research ; Publications ; Surveys and Questionnaires ; Research Design

No abstract available.
Gwangju* ; Humans

Atypical polypoid adenomyoma(APA) is a rare benign polypoid tumor arising in the uterine endometrium which was first designated by Mazur in 1981. Microscopic examination reveals architecturally and cytologically atypical endometrial glands separated by intersecting fascicles of smooth muscle cells. The tumor can be misdiagnosed as endometrial adenocarcinoma with myometrial invasion, especially on microscopic examination of a curettage specimen. However a granulation tissue-like stromal response is absent and the smooth muscle in APA is more cellular than that of normal myometrium. We are reporting 2 cases of APA of the uterine endometrium which are 1.5 cm and 1.7 cm in size, respectively, in a 30 and a 22 year-old women. This is the first report in Korean literature using the immunohistochemical staining for smooth muscle actin and desmin.
Female ; Humans ; Adenocarcinoma

No abstract available.
Diagnosis* ; Leptospirosis*

No abstract available.
Diagnosis* ; Leptospirosis*

No abstract available.
Precursor Cell Lymphoblastic Leukemia-Lymphoma*

The effect of genistein, widely used as a specific tyrosine kinase inhibitor, on rat brain Kv1.5 channels which were stably expressed in Chinese hamster ovary cells was investigated using the whole-cell patch-clamp technique. Genistein inhibited Kv1.5 currents at +50 mV in a concentration-dependent manner, with an IC50 of 54.7+/-8.2 micrometer and a Hill coefficient of 1.1+/-0.2. Pretreatment of Kv1.5 with protein tyrosine kinase inhibitors (10 micrometer lavendustin A and 100 micrometer AG1296) and a tyrosine phosphatase inhibitor (500 micrometer sodium orthovanadate) did not block the inhibitory effect of genistein. The inhibition of Kv1.5 by genistein showed voltage-independence over the full activation voltage range positive to 0 mV. The activation (at +50 mV) kinetics was significantly delayed by genistein: time constant for an activation of 1.4+/-0.2 msec under control conditions and 10.0+/-0.5 msec in the presence of 60 micrometer genistein. Genistein also slowed the deactivation of the tail currents, resulting in a crossover phenomenon: a time constant of 11.4+/-1.3 msec and 40.0+/-4.2 msec under control conditions and in the presence of 60 micrometer genistein, respectively. Inhibition was reversed by the application of repetitive depolarizing pulses, especially during the early part of the activating pulse. These results suggest that genistein directly inhibits Kv1.5 channels, independent of phosphotyrosine-signaling pathway.
Animals ; Brain* ; Clone Cells* ; Cricetinae ; Cricetulus ; Female ; Genistein* ; Inhibitory Concentration 50 ; Kinetics ; Ovary ; Patch-Clamp Techniques ; Potassium Channels* ; Potassium* ; Protein-Tyrosine Kinases* ; Rats* ; Sodium ; Tyrosine*

The goal of this study was to analyze the effects of genistein, a widely used tyrosine kinase inhibitor, on cloned Shaw-type K+ currents, Kv3.1 which were stably expressed in Chinese hamster ovary (CHO) cells, using the whole-cell configuration of patch-clamp techniques. In whole-cell recordings, genistein at external concentrations from 10 to 100 micrometer accelerated the rate of inactivation of Kv3.1 currents, thereby concentration-dependently reducing the current at the end of depolarizing pulse with an IC50 value of 15.71+/-0.67 micrometer and a Hill coefficient of 3.28+/-0.35 (n=5). The time constant of activation at a 300 ms depolarizing test pulses from -80 mV to +40 mV was 1.01+/-0.04 ms and 0.90+/-0.05 ms (n=9) under control conditions and in the presence of 20 micrometer genistein, respectively, indicating that the activation kinetics was not significantly modified by genistein. Genistein (20 micrometer) slowed the deactivation of the tail current elicited upon repolarization to -40 mV, thus inducing a crossover phenomenon. These results suggest that drug unbinding is required before Kv3.1 channels can close. Genistein-induced block was voltage-dependent, increasing in the voltage range (-20 mV~0 mV) for channel opening, suggesting an open channel interaction. Genistein (20 micrometer) produced use-dependent block of Kv3.1 at a stimulation frequency of 1 Hz. The voltage dependence of steady-state inactivation of Kv3.1 was not changed by 20 micrometer genistein. Our results indicate that genistein blocks directly Kv3.1 currents in concentration-, voltage-, time-dependent manners and the action of genistein on Kv3.1 is independent of tyrosine kinase inhibition.
Animals ; Clone Cells ; Cricetinae ; Cricetulus ; Female ; Genistein* ; Inhibitory Concentration 50 ; Kinetics ; Ovary ; Patch-Clamp Techniques ; Protein-Tyrosine Kinases* ; Tyrosine*

The interaction of cyclosporine A (CsA), an immunosuppressant, with rat brain Kv1.5 (Kv1.5) channels, which were stably expressed in Chinese hamster ovary cells, was investigated using the whole-cell patch-clamp technique. CsA reversibly blocked Kv1.5 currents at +50 mV in a reversible concentration- dependent manner with an apparent IC50 of 1.0microM. Other calcineurin inhibitors (cypermethrin, autoinhibitory peptide) had no effect on Kv1.5 and did not prevent the inhibitory effect of CsA. Fast application of CsA led to a rapid and reversible block of Kv1.5, and the onset time constants of the CsA-induced block were decreased in a concentration-dependent manner. The CsA-induced block of Kv1.5 channels was voltage-dependent, with a steep increase over the voltage range of channel opening. However, the block exhibited voltage independence over the voltage range in which channels were fully activated. The rate constants for association and dissociation of CsA were 7.0microM-1s-1 and 8.1 s-1, respectively. CsA slowed the deactivation time course, resulting in a tail crossover phenomenon. Block of Kv1.5 by CsA was use-dependent. CsA also blocked Kv1.3 currents at +50 mV in a reversible concentration-dependent manner with an apparent IC50 of 1.1microM. The same effects of CsA on Kv1.3 were also observed in excised inside-out patches when applied to the internal surface of the membrane. The present results suggest that CsA acts directly on Kv1.5 currents as an open-channel blocker, independently of the effects of CsA on calcineurin activity.
Animals ; Brain ; Calcineurin* ; Clone Cells* ; Cricetinae ; Cricetulus ; Cyclosporine* ; Female ; Inhibitory Concentration 50 ; Membranes ; Ovary ; Patch-Clamp Techniques ; Rats

This case report describes a patient with semipedunclated granuylar cell tumor(granular cell myoblastoma) of the proximal ascending colon removed by endoscopic polypectomy. A 39-year old femalie was visited to our hospital for intermittent abdominal pain and loose stool. Colonoscopic examination showed a semipedunclated lesion covered with yellowish white smooth mucosa in the proximal ascending colon. The tumor was removed by endoscopic polypectomy. The collected specimen was 0.9x0.8 cm in size. The cut surface of the specimen showed a white round firm tumor covered with mormal epithelium of the colon. Using immunohistochemical study, the tumor cells were to be positively stained by S-100 protein and negatively stained by desmin, which supports the concept of the Schwann cell origin of granular cell tumor. In Korea, 2 cases of granular cell tumor of the colon and rectum, which were treated by surgical removal, have been reported. This case in the first endoscopic polypectomy of granular cell tumor of the colon and retum in Korea. The endoscopic polypectomy is thought to be useful for the therapy of small pedunclated or semipedunclated granular cell tumor, intracolonic type.
Abdominal Pain ; Adult ; Colon ; Colon, Ascending* ; Desmin ; Epithelium ; Granular Cell Tumor* ; Humans ; Korea ; Mucous Membrane ; Rectum ; S100 Proteins