1.Surgical Experience with Infective Endocarditis and Aortic Root Abscess.
Sak LEE ; Byung Chul CHANG ; Han Ki PARK
Yonsei Medical Journal 2014;55(5):1253-1259
PURPOSE: This study was conducted to evaluate the surgical outcomes of active infective endocarditis with aortic root abscess formation. MATERIALS AND METHODS: Between February 1999 and June 2012, 49 patients underwent surgery for active endocarditis with aortic root abscess. The infected valve was native in 29 patients and prosthetic in 20 patients. The patients' mean age was 50+/-14 years, and 36 patients were male. Surgery was urgent/emergent in 15 patients (31%). The abscess involved the aortic annulus (11), left ventricular outflow tract (18), fibrous trigone (16), and mitral annulus (4). In all patients, wide debridement of abscess and aortic valve replacement with or without patch reconstruction of aortic root or annulus was performed. RESULTS: There were 6 (12%) operative deaths. Causes of early mortality were sepsis (2) and multi-organ failure (4). On postoperative echocardiogram, there was significant improvement of left ventricular dimension (LVEDD, from 58.8+/-11.8 mm to 52.6+/-8.2 mm, p<0.001); however, LV ejection fraction was significantly decreased (from 61.4+/-12.0% to 49.8+/-16.5%, p<0.001). The mean follow-up duration was 68.7+/-40.4 months. There was no late death or recurrent endocarditis during follow up. New York Heart Association functional class significantly improved from 3.2+/-0.7 to 1.2+/-0.4 (p<0.001). Kaplan-Meier estimated survival at 10 years was 87.2%. CONCLUSION: Surgical treatment for active endocarditis with aortic root abscess is still challenging, and was associated with high operative mortality. Nevertheless, long-term survival was excellent with good functional capacity after recovery from the early postoperative period.
Abscess/*surgery
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Adult
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Aortic Valve/microbiology/*surgery
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Debridement
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Endocarditis/*surgery
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Female
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Follow-Up Studies
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Heart Valve Prosthesis/*microbiology
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Heart Valve Prosthesis Implantation/*adverse effects/mortality
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Humans
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Intraoperative Complications/epidemiology
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Kaplan-Meier Estimate
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Male
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Middle Aged
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Postoperative Complications/epidemiology
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Retrospective Studies
2.Native valve endocarditis due to extended spectrum beta-lactamase producing Klebsiella pneumoniae.
Hyun Ae JUNG ; Young Eun HA ; Damin KIM ; Jihyun PARK ; Cheol In KANG ; Doo Ryeon CHUNG ; Seung Woo PARK ; Ki Ik SUNG ; Jae Hoon SONG ; Kyong Ran PECK
The Korean Journal of Internal Medicine 2014;29(3):398-401
No abstract available.
Aged
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Anti-Bacterial Agents/therapeutic use
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Aortic Valve/*microbiology/surgery/ultrasonography
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Cross Infection/diagnosis/*microbiology/therapy
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Diffusion Magnetic Resonance Imaging
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Endocarditis, Bacterial/diagnosis/*microbiology/therapy
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Heart Valve Prosthesis Implantation
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Humans
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Klebsiella Infections/diagnosis/*microbiology/therapy
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Klebsiella pneumoniae/drug effects/*enzymology/pathogenicity
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Male
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Microbial Sensitivity Tests
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Predictive Value of Tests
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Sepsis/diagnosis/*microbiology/therapy
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Treatment Outcome
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beta-Lactamases/*metabolism
3.The effect of surface free energy parameters of diamond-like carbon films deposited on medical polyethylene terephthalate on bacterial adhesion.
Jin WANG ; Changjiang PAN ; Peng LI ; Yongxiang LENG ; Junying CHEN ; Guojiang WAN ; Ping YANG ; Hong SUN ; Nan HUANG
Journal of Biomedical Engineering 2006;23(2):342-345
Diamond-like carbon (DLC) films were deposited by acetylene plasma immersion ion implantation-deposition (PIII-D) on biomedical polyethylene terephthalate (PET). The capacities of Staphylococcus aureus (SA), Staphylococcus epidermidis (SE), Escherichia coli (EC), Pseudomonas aeruginosa (PA) and Candida albicans (CA) for adhesion to PETs are quantitatively determined by the plate counting and Gamma-ray counting of 125I radio labeled bacteria in vitro. The results indicate that the capacities of five types of bacteria for adhesion to PETs are all suppressed by C2H2 PIII-D (P<0.05). The surface energy components of the various substrates and bacteria are calculated based on measurements in water, formamide and diiodomethane and Lifshitz-van del Waals/acid-base approach (LW-AB). The surface free energies obtained are used to calculate the interfacial free energies of adhesion (deltaF(adh)) of five kinds of bacteria on various substrates, and the results show that it is energetically unfavorable for bacterial adhesion to the DLC films already deposited on PET by C2H2 PIII-D.
Bacterial Adhesion
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drug effects
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physiology
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Carbon
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chemistry
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Coated Materials, Biocompatible
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chemistry
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Diamond
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chemistry
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Escherichia coli
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drug effects
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Heart Valve Prosthesis
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microbiology
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Materials Testing
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Polyethylene Terephthalates
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chemistry
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Staphylococcus aureus
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drug effects
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Staphylococcus epidermidis
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drug effects
4.Two Episodes of Stenotrophomonas maltophilia Endocarditis of Prosthetic Mitral Valve: Report of a Case and Review of the Literature.
Jae Han KIM ; Shin Woo KIM ; Hye Ryun KANG ; Gi Bum BAE ; Jee Hyun PARK ; Eon Jeong NAM ; Young Mo KANG ; Jong Myung LEE ; Nung Soo KIM
Journal of Korean Medical Science 2002;17(2):263-265
Stenotrophomonas maltophilia (previously named Xanthomonas maltophilia) is an aerobic, non-fermentive, Gram-negative bacillus that is wide spread in the environment. It was considered to be an organism with limited pathogenic potential, which was rarely capable of causing diseases in human other than those who were in debilitated or immunocompromised state. More recent studies have established that Stenotrophomonas maltophilia can behave as a true pathogen. Endocarditis due to this organism is rare, and only 24 cases of Stenotrophomonas maltophilia endocarditis have been reported in the medical literature. Most cases were associated with risk factors, including intravenous drug abuse, dental treatment, infected intravenous devices, and previous cardiac surgery. We present a case with two episodes of Stenotrophomonas maltophilia endocarditis after mitral valve prosthesis implantation, which was treated with antibiotics initially, and a combination of antibiotics and surgery later. To our knowledge, this is the first case of repetitive endocarditis due to Stenotrophomonas maltophilia.
Adult
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Anti-Bacterial Agents/*therapeutic use
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Bioprosthesis/adverse effects/*microbiology
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Endocarditis, Bacterial/*drug therapy/physiopathology
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Gentamicins/therapeutic use
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Gram-Negative Bacterial Infections/*drug therapy/physiopathology
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Heart Valve Prosthesis/adverse effects/*microbiology
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Humans
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Male
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Mitral Valve
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Recurrence
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Stenotrophomonas maltophilia/*drug effects
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Treatment Outcome
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Trimethoprim-Sulfamethoxazole Combination/*therapeutic use
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Vancomycin/therapeutic use