Heart Diseases ; genetics ; Humans ; Proteomics

No abstract available.
Cardiomyopathy, Hypertrophic/genetics ; Chromosome Aberrations ; Heart Defects, Congenital/genetics ; Heart Diseases/*genetics ; Human

No abstract available.
Cardiomyopathy, Hypertrophic/genetics ; Chromosome Aberrations ; Heart Defects, Congenital/genetics ; Heart Diseases/*genetics ; Human

AMP-Activated Protein Kinases ; genetics ; Heart Diseases ; Humans ; Syndrome

Heart Diseases/genetics* ; Humans ; Nuclear Proteins ; Transcription Factors

Heart ; Humans ; Molecular Biology ; Neuromuscular Diseases/genetics* ; Phenotype

Some non-coding RNAs (ncRNA), as functional RNA molecules, lack potential to encode proteins, but can affect gene expression and disease progression through a variety of mechanisms. In multiple myeloma (MM), cardiovascular disease is one of the most common complications, which may be related to a variety of factors, including patient's own factors, disease-related factors, drug factors, etc. Non-coding RNA is considered to be an important regulator of cardiovascular event risk factors and cell function, and an important candidate target for improving the condition and prognostic assessment. This article briefly summarized the role of non-coding RNA in cardiac amyloidosis caused by MM, damage to the heart by inflammatory factors, and heart disease caused by chemotherapy drugs in recent years.
Cardiovascular Diseases ; Heart Diseases ; Humans ; Multiple Myeloma/genetics* ; Prognosis ; RNA, Untranslated/genetics*

Pathological processes such as myocardial apoptosis, cardiac hypertrophy, myocardial fibrosis, and cardiac electrical remodeling are involved in the development and progression of most cardiac diseases. MicroRNA-21 (miR-21) has been found to play an important role in heart diseases as a novel type of endogenous regulators, which can inhibit cardiomyocyte apoptosis, improve hypertension and cardiac hypertrophy, promote myocardial fibrosis and atrial electrical remodeling. In this review, we summarize the research progress on the function of miR-21 in heart diseases and its mechanism, and discuss its potential application in diagnosis and treatment of heart diseases.
Cardiomegaly ; genetics ; physiopathology ; Heart Diseases ; genetics ; physiopathology ; Humans ; MicroRNAs ; genetics ; metabolism ; Myocardium ; pathology

Arrhythmias, Cardiac ; Genetic Diseases, X-Linked/genetics* ; Gigantism/genetics* ; Heart Defects, Congenital/genetics* ; Humans ; Intellectual Disability/genetics* ; Male ; Neuroblastoma

Hereditary cardiac disease accounts for a large proportion of sudden cardiac death (SCD) in young adults. Hereditary cardiac disease can be divided into hereditary structural heart disease and channelopathies. Hereditary structural heart disease mainly includes hereditary cardiomyopathy, which results in arhythmia, heart failure and SCD. The autopsy and histopathological examinations of SCD caused by channelopathies lack characteristic morphological manifestations. Therefore, how to determine the cause of death in the process of examination has become one of the urgent problems to be solved in forensic identification. Based on the review of recent domestic and foreign research results on channelopathies and hereditary cardiomyopathy, this paper systematically reviews the pathogenesis and molecular genetics of channelopathies and hereditary cardiomyopathy, and discusses the application of postmortem genetic testing in forensic identification, to provide reference for forensic pathology research and identification of SCD.
Autopsy/methods* ; Channelopathies/genetics* ; Death, Sudden, Cardiac/pathology* ; Genetic Testing ; Heart Diseases/genetics* ; Humans ; Young Adult