Background: In our country the thyroid diseases usually diagnosed using only laboratory indicators of thyroid hormons such as T3, T4, TSH and medical symptom. It means there are considerably late diagnosing of thyroid failure. In recently hypothyroidism and hypothyroidism are being diagnosed by specific thyroid antibodies which are instead during thyroid disorders in the worldwide. Although this diagnostic method is used in some laboratory in our country but their diagnostic significance have not yet been determined. It is important to lunce diagnostic methods for thyroid antibodies specially essential for endocrine doctors. Objective: To determine the diagnostic significance of thyroglobulin antibody and thyroid peroxidase antibodies in relation with thyroid disease. Research materials and methods: In this research of thyroid peroxidase antybody and thyroglobulin antibody, we use 20-64 age 23 patients who have hypothyrodism diagnostics, 36 patients how have hyperhotyrodism diagnostics, 30 patients who are relatively healthy and their disease was denied on symptom and laboratory test, total 89 people. Results: There were 57 female and 32 male from total 89 people investigated for this study. The traditional determination of thyroid hormones for diagnosis of thyroid diseases still have high diagnostic significance. The newly launched and used in our study anti-TPO and anti-Tg have very high significance for thyroid diagnosis. We found that anti-TPO antibody has primary information indicator and anti-Tg antibody is secondary information indicator for the diagnosis of thyroid disorder. Conclusion: 1.Among 59 patients with thyroid diseases 89.8% (n=53) of them determined increased anti-TPO concentration and 61% (n=36) of them increased anti-Tg concentration. It shows increase of these antibodies have high diagnostic significance for thyroid diseases. 2.For hyperthytiodism the anti-TPO has strong supportive information indicator (карра=0,64) and anti-Tg has primary information indicator (карра=0,84). 3.For hypothytiodism the anti-TPO has primary information indicator (карра=0,78) and anti-Tg has weak supportive information indicatot (карра=0,24).

Vitamin D deficiency is a major health problem worldwide, especially in the elderly, so that an accurate assessment of its prevalence is essential for planning reliable healthcare policy throughout the lifespan. Purpose: The aim of the oncentrationofpresent study wasto assess the25-hydroxyvitamin D 25OHD) across different as well as the mild andmoderate deficiencies ages and genders. Methods: We searched the database of the local Laboratory Information System to retrieve results of 25OHD tests performed on the whole cohort of presumably Mongolian participants aged >22 yrs, who were referred to our laboratory in Gurvan Gal Hospital’s clinical laboratory, a 1-year period (January 2011 - January 2012). Results: Results for 25OHD testing were retrieved for 120 participants. No significant differences between females and males were observed for 25OHD values(20 [4-17.89]ng/ml versus 53 [4-20.06]ng/ml; p=0.3). A non significant variation of 25OHD values was also found by ANOVA analysis throughout 3 age cohorts (22-40, 41-60, >60 yrs), in both genders. In each age group, the values of 25OHD did not significantly differ between genders. Conclusions: We observed a high prevalence of vitamin D deficiency in a Mongolians. Lifestyle factors, including smoking, and physical activity, were significant predictors of serum 25-hydroxyvitamin D concentration.

Rationale: Effective healthcare starts with an accurate diagnosis, and laboratory plays an important role in this. All health laboratories, be it clinical, animal health, food safety, or environmental health laboratory, contribute to health care and public health security. Therefore, many public health programs are conducting laboratory assessments. The assessment findings can be used for identification of areas in which efforts should be directed in order to strengthen the national laboratory system and health laboratories. Goal: The goal of the project was to assess the national laboratory system and health laboratories of Mongolia. Methods and materials: Laboratory assessment tool (LAT) developed by WHO was used for the assessment of two areas: 1. strategic organization at the national level, and 2. specific technical capacities at the laboratories level. The national laboratory system was assessed using LAT System questionnaire with the participation of MOH officers, and the assessment of laboratories was conducted using LAT Facility questionnaire with the involvement of laboratories representing public and private sectors, all three levels of urban and rural health care organizations, and clinical and public health areas of laboratory services. Results: The strongest areas of the national laboratory system at the policy and regulatory level were “Coordination and management” and “Laboratory information system”. The weaker (below 75%) areas were “Structure and organizations”, “Regulations”, “Infrastructure” and “Human resources”. The insufficient infrastructure score was due to the lack of financing. The main problems detected in the area of Human resources were insufficient financial and organizational support of continuous education of laboratory workers, shortage of trained personnel and incomplete national registration system of laboratory professionals. The results of the laboratory capacities showed that the assessed laboratories were strong in “Data and information management”, “Specimen collection and handling” and “Consumables and reagents”. The testing performance of most laboratories was excellent but the external quality assurance was not available in some test disciplines. The weaker areas of the laboratories were “Facilities”, “Public health functions” and “Biorisk management”. The module “Organization and management” showed lower score mainly due to insufficient budget. The same was with “Facilities”. Although the general safety management of laboratories was very good, the biosafety component was not incorporated in it. Conclusions and recommendations: 1.A national regulatory body needs to be established for the registration of all laboratories and laboratory professional staff. 2.Each laboratory should formally designate an appropriately trained Quality manager, 3.Set-up a formal professional development/ continuous education system for laboratory professionals. 4.Develop biosafety policy and implementation plan. 5.Establish a comprehensive national laboratory information management system (LIMS).

Abstract: The lactate dehydrogenase (LDH) enzyme is widely distributed in tissue, particularly heart, liver muscle, and kidney. The LDH in serum can be separated into five different isoenzymes based on their electrophoretic mobility. Each isoenzyme is a tetramer composed of two different subunits. These two subunits have been designated heart and muscle, based on their polypeptide chains. There are two homotetramers, LDH-1 and LDH-5, and three hybrid isoenzymes. Elevated serum levels of LDH have been observed in a variety of disease states. The highest levels are seen in patients with megaloblastic anemia, disseminated carcinoma, and shock. Moderate increases occur in muscular disorders, nephrotic syndrome, and cirrhosis. Mild increases in LDH activity have been reported in cases of myocardial or pulmonary infarction, leukemia, hemolytic anemia, and hepatitis. This study aims to compare a LDH activity in comparatively healthy Mongolian population using highly sensitivity modern technology and evaluate their contents with age, sex, and work adults differences, For this purpose there were chosen 3742 healthy adults (1597 males and 2145 females). The enzyme activity were investigated in Mobio laboratory using fully automated analyzer COBAS Integra-400. Study results were assessed using Microsoft Excel SPSS-10 standard program and evaluation. The study results show that mathematical mean of LDH activity of healthy Mongolian population is 322.6 u/l, quadratic mean of deviation is 44.9 u/l, and significant distribution is 187.2-442.6 u/l with p=0,99. The mathematical mean of LDH activity of healthy Mongolian man 187-444 u/l, but for women it is 187-438 u/l, with haven’t differences. The level LDH activity of healthy Mongolian population does not depend from age. The level LDH activity of healthy Mongolian population have differences from work adults. Conclusion: 1.From the findings indicated LDH activity by 187.2-442.6 u/l. 2.Study findings shown LDH activity level not influenced for age and sex. 3.There fore we defined LDG activity level influenced physical and mental overload.

Background: Selenium (Se) is a trace element important for health. Its defciency has adverse effects on reproduction, immunocompetence and cardiovascular status. There is growing evidence that higher Se intakes are associated with reduced cancer risk. To date, there have been no studies conducted on the Se status of Mongolian children. Materials and Methods Non-fasting morning blood samples were collected from 240 children (122 male and 118 female) 6-36 months of age from the capital city of Mongolia and four provinces located in the south, north, east and west of the country. Inclusion criteria were apparently healthy children with no evidence of infection within the previous 7 days. The serum concentrations of Se were determined using graphite furnace atomic absorption spectrometry. Results: The mean serum Se concentration was 0.79 µmol/L. The indicator was higher for children in the rural provinces compared to those who lived in the capital city (0.81 µmol/L vs. 0.76 µmol/L, p=0.029). There was no statistically signifcant difference in the levels of Se detected between boys and girls (0.79 µmol/Lvs. 0.78 µmol/L, p=0.551). The serum concentration of Se increased with age (0.73µmol/L in the 6-11.9 months age group, 0.79 µmol/L in children aged 12-23.9 months and 0.82 µmol/L in 24-36-month-old participants). The prevalence of low serum Se in the surveyed population (<0.82 μmol/L) was 55.8%. The Se defciency tends to decrease with age (63.8% in the 6-11.9 months age group, 57.6% in participants 12-23.9 months of age and 48.2% in the oldest group). The prevalence of Se defciency is lower among children living in the western regions (38.3%) than among those from other areas of the country (60.4%). Conclusion: The high prevalence of Se defciency among Mongolian children shows that a wider survey that looks at the relationship between the blood Se and its concentrations in food and soil is needed.