1.Life-threatening Duodenal Ulcer Bleeding from a Ruptured Gastroduodenal Artery Aneurysm in a Patient with Neurofibromatosis Type 1.
Kyu Sung IM ; Sunyong KIM ; Jun Uk LIM ; Jung Won JEON ; Hyun Phil SHIN ; Jae Myung CHA ; Kwang Ro JOO ; Joung Il LEE ; Jae Jun PARK
The Korean Journal of Gastroenterology 2015;66(3):164-167
Vasculopathy is rarely reported in neurofibromatosis type 1, but when it occurs it primarily involves the aorta and its main branches. Among vasculopathies, aneurysmal dilatation is the most common form. Although several case reports concerning aneurysms or pseudoaneurysms of visceral arteries in neurofibromatosis type 1 patients have been reported, there are no reports describing gastroduodenal artery aneurysms associated with neurofibromatosis type 1. We experienced a case of life-threatening duodenal ulcer bleeding from a ruptured gastroduodenal artery aneurysm associated with neurofibromatosis type 1. We treated our patient by transarterial embolization after initial endoscopic hemostasis. To our knowledge, this is the first reported case of its type. High levels of suspicion and prompt diagnosis are required to select appropriate treatment options for patients with neurofibromatosis type 1 experiencing upper gastrointestinal bleeding. Embolization of the involved arteries should be considered an essential treatment over endoscopic hemostasis alone to achieve complete hemostasis and to prevent rebleeding.
Adult
;
Aneurysm/*diagnosis/etiology
;
Arteries
;
Embolization, Therapeutic
;
Gastroscopy
;
Head and Neck Neoplasms/complications/*diagnosis
;
Hepatic Artery/diagnostic imaging
;
Humans
;
Male
;
Neurofibromatosis 1/complications/*diagnosis
;
Peptic Ulcer Hemorrhage/*etiology
;
Radiography
2.Primary Cutaneous Mucinous Carcinoma of the Eyelid.
Min Sung TAK ; Seong Eun CHO ; Sang Gue KANG ; Chul Han KIM ; Dong Won KIM
Archives of Craniofacial Surgery 2016;17(3):176-179
Primary cutaneous mucinous carcinoma (PCMC) is a rare low-grade malignant neoplasm derived from the eccrine glands. PCMC most commonly arises in the head and neck, with the eyelid being the most common site of origin. This case report describes a 51-year-old male with a painless, pigmented superficial nodular lesion over his right lower eyelid. The lesion was considered to be benign, and the initial treatment was simple excision with a 3-mm margin. However, histologic examination revealed the diagnosis of PCMC, and the patient underwent re-excision of the tumor site with an additional 3-mm margin from the initial scar. Histologic study of this second margin was free of any malignant cells. The patient experienced no postoperative complication or recurrence after 2 years. In our case, the skin lesion had benign morphologic findings and was strongly suspected to be a benign mass. Physicians should be aware of this tumor and be able to differentiate it from benign cystic or solid eyelid lesions.
Adenocarcinoma, Mucinous*
;
Cicatrix
;
Diagnosis
;
Eccrine Glands
;
Eyelids*
;
Head
;
Humans
;
Male
;
Middle Aged
;
Mucins*
;
Neck
;
Postoperative Complications
;
Recurrence
;
Skin
;
Skin Neoplasms
3.Primary Cutaneous Mucinous Carcinoma of the Eyelid.
Min Sung TAK ; Seong Eun CHO ; Sang Gue KANG ; Chul Han KIM ; Dong Won KIM
Archives of Craniofacial Surgery 2016;17(3):176-179
Primary cutaneous mucinous carcinoma (PCMC) is a rare low-grade malignant neoplasm derived from the eccrine glands. PCMC most commonly arises in the head and neck, with the eyelid being the most common site of origin. This case report describes a 51-year-old male with a painless, pigmented superficial nodular lesion over his right lower eyelid. The lesion was considered to be benign, and the initial treatment was simple excision with a 3-mm margin. However, histologic examination revealed the diagnosis of PCMC, and the patient underwent re-excision of the tumor site with an additional 3-mm margin from the initial scar. Histologic study of this second margin was free of any malignant cells. The patient experienced no postoperative complication or recurrence after 2 years. In our case, the skin lesion had benign morphologic findings and was strongly suspected to be a benign mass. Physicians should be aware of this tumor and be able to differentiate it from benign cystic or solid eyelid lesions.
Adenocarcinoma, Mucinous*
;
Cicatrix
;
Diagnosis
;
Eccrine Glands
;
Eyelids*
;
Head
;
Humans
;
Male
;
Middle Aged
;
Mucins*
;
Neck
;
Postoperative Complications
;
Recurrence
;
Skin
;
Skin Neoplasms
4.Primary Malignant Teratoma with a Primitive Neuroectodermal Tumor Component in Thyroid Gland: A Case Report.
Eunyoung KIM ; Tae Seok BAE ; Youngmee KWON ; Tae Hyun KIM ; Ki Wook CHUNG ; Sun Wook KIM ; Jungsil RO ; Eun Sook LEE
Journal of Korean Medical Science 2007;22(3):568-571
Teratomas comprise the most common extragonadal germ cell tumors in childhood. Most teratomas involving the thyroid are benign and occur in children. However, the adult cases reported are mostly malignant and commonly arise in the thyroid. We report a case of a 31-yr-old female with a huge neck mass. Pathologic examination revealed it to be malignant teratoma composed of primitive neuroepithelial tissue with primitive neural tubes and loose myxoid to fibrous immature mesenchymal stroma. The patient underwent extensive evaluation of the thyroid gland with computed tomography (CT) scan and positron emission tomography (PET) scan, which revealed no evidence of metastatic disease. She underwent total thyroidectomy with bilateral modified radical neck dissection, intensive chemotherapy and radiotherapy. At 22-months of follow-up, the patient has remained euthyroid and showed no evidence of recurrence. This is the first case, to our knowledge, of malignant thyroid teratoma with a exuberant primitive neuroectodermal tumor component in Korea.
Adult
;
Female
;
Head and Neck Neoplasms/pathology
;
Humans
;
Neoplasm Metastasis
;
Neuroectodermal Tumors, Primitive/*complications/diagnosis/*pathology
;
Positron-Emission Tomography/methods
;
Teratoma/*complications/diagnosis/*pathology
;
Thyroid Diseases/diagnosis
;
Thyroid Gland/*pathology
;
Thyroidectomy
;
Tomography, X-Ray Computed
5.Clinical analysis of periampullary cancer.
Ki Young YANG ; Kwon Mook CHAE ; Byung Jun SO ; Jae Hyung KIM ; Hak cheoul KIM
Korean Journal of Hepato-Biliary-Pancreatic Surgery 1997;1(2):133-141
BACKGROUND: Periampullary cancer is referred to malignant tumor that occurs in pancreatic head, distal common bile duct, ampulla of Vater and duodenum according to anatomical position and poor prognosio he clinical symptoms, diagnosis and treatments are identical to positional characteristics. Since 1935, after Whipple originally described the removal of periampullary tumors, both the surgical method and the outcome associated with it have changed extensively. The mortality and morbidity rates associated with the procedure as performed today have decreased. (Objective) The authors evaluated the incidence, resectability and the clinical outcome of periampullary cancer. PATIENTS AND METHODS: We performed the clinical analysis retrospectively on 124 cases of periampullary cancer in the Department of Surgery and Internal medicine, School of Medicine, Wonkwang University from Oct. 1986 to July 1996. RESULTS: There were 77 men and 47 women and the male to female ratio was 1.64:1. The prevalent ages were in the 7th decade (44.4%), and 8th decade (27.4%). Fifty-four pancreatic head carcinomas(43.4%), 40 distal common bile duct carcinomas(32.3%), 28 Ampulla of Vater carcinomas( 22.6%), and 2 carcinomas of the periampullary duodenum(1.6%) were found. The major clinical symptoms and signs were abdominal pain (71%), jaundice (60.5%), and weight loss(33.1%). Resectability of pancreatic head cancer, distal common bile duct cancer, and ampulla of Vater cancer were 44.4%, 72.5%, and 85.7%, respectively. The mean resectability rate was 63.7%. The resection was performed in 60 cases ; Pylorus-preserving pancreaticoduodenectomy (29 cases), Whipple's operation (28 cases), total pancreatectomy (3 cases). The palliative procedure was performed in 14 cases ; gastrojejunostomy (6 cases), choledochotomy with T-tube drainage (5 cases), explolaparotomy with biopsy (4 cases). Postoperative mortality in resection surgery was 8.3%. Postoperative complication in resection surgery was 36.7%. The major causes of postoperative complications were wound complication( 16.7%) and respiratory complication(5.0%). The 1- year and 3-year survival rates after the resection were 47.1% and 22.0%, but those of nonresection group were 15.4% and 0%. The survival rate of resection group was significantly better than that of nonresection group (p<0.05). In the nonresection group, the 1-year survival rate in conservative treatment group including interventional procedure was 8.7% and 0% in palliative surgery group. Survival of nonoperable group was significantly better than that of palliative surgery group (p<0.05). According to anatomical tumor site, the 1-year and 3-year survival rates of pancreatic head cancer were 23.1%, 11.8%, and those of distal common bile duct cancer were 34.2%, 6.5%, and Ampulla of vater cancer 63.0%, 27.0%, respectively. SUMMARY: The pancreas head is the most common site of periampullary cancer. Survival of resection group and conservative treatment group is better than that of nonresection group and palliative surgery group, respectively.
Abdominal Pain
;
Ampulla of Vater
;
Biopsy
;
Common Bile Duct
;
Diagnosis
;
Drainage
;
Duodenum
;
Female
;
Gastric Bypass
;
Head
;
Head and Neck Neoplasms
;
Humans
;
Incidence
;
Internal Medicine
;
Jaundice
;
Male
;
Mortality
;
Palliative Care
;
Pancreas
;
Pancreatectomy
;
Pancreaticoduodenectomy
;
Postoperative Complications
;
Retrospective Studies
;
Survival Rate
;
Wounds and Injuries
6.Analysis of Dysphagia Patterns Using a Modified Barium Swallowing Test Following Treatment of Head and Neck Cancer.
So Yoon LEE ; Bo Hwan KIM ; Young Hak PARK
Yonsei Medical Journal 2015;56(5):1221-1226
PURPOSE: The purposes of this study were to evaluate specific dysphagia patterns and to identify the factors affecting dysphagia, especially aspiration, following treatment of head and neck cancer. MATERIALS AND METHODS: A retrospective analysis of 57 patients was performed. Dysphagia was evaluated using a modified barium swallow (MBS) test. The MBS results were rated on the 8-point penetration-aspiration scale (PAS) and swallowing performance status (SPS) score. RESULTS: Reduced base of the tongue (BOT) retraction (64.9%), reduced laryngeal elevation (57.9%), and cricopharyngeus (CP) dysfunction (47.4%) were found. Reduced BOT retraction was correlated with clinical stage (p=0.011) and treatment modality (p=0.001). Aspiration in 42.1% and penetration in 33.3% of patients were observed. Twenty-four patients had PAS values over 6, implying aspiration. Forty-one patients had a SPS score of more than 3, 25 patients had a score greater than 5, and 13 patients had a SPS score of more than 7. Aspiration was found more often in patients with penetration (p=0.002) and in older patients (p=0.026). In older patients, abnormal swallowing caused aspiration even in those with a SPS score of more than 3, irrespective of stage or treatment, contrary to younger patients. Tube feeders (n=20) exhibited older age (65.0%), dysphagia/aspiration related structures (DARS) primaries (75.0%), higher stage disease (66.7%), and a history of radiotherapy (68.8%). CONCLUSION: Reduced BOT retraction was the most common dysphagia pattern and was correlated with clinical stage and treatment regimens including radiotherapy. Aspiration was more frequent in patients who had penetration and in older patients. In contrast to younger patients, older patients showed greater risk of aspiration even with a single abnormal swallowing irrespective of stage or treatment.
Adult
;
Aged
;
Aged, 80 and over
;
*Barium Sulfate
;
Combined Modality Therapy
;
Contrast Media
;
Deglutition
;
*Deglutition Disorders/diagnosis/etiology/physiopathology
;
Enteral Nutrition
;
Female
;
Head and Neck Neoplasms/complications/*radiotherapy
;
Humans
;
Male
;
Middle Aged
;
*Respiratory Aspiration/diagnosis/etiology/physiopathology
;
Retrospective Studies
7.The Significance of Drain Amylase Level for Diagnosis of Pancreatic Leakage after Pancreatoduodenectomy.
Seungjin KIM ; Dongeun PARK ; Kwonmook CHAE
Journal of the Korean Surgical Society 2004;66(5):409-414
PURPOSE: Pancreatoduodenectomy is a common procedure for periampullary cancer, but pancreatic leakage is the most dreaded complication after pancreatoduodenectomy. The aim of our study was to evaluate the correlation between the level of amylase in the drain fluid and the level of development of the complications that are related to pancreatic leakage after pancreatoduodenectomy. METHODS: Fifty-one consecutive patients who underwent pancreatoduodenectomy and pancreaticojejunostomy by two surgeons between January 1998 and August 2002 were evaluated retrospectively. A pancreaticojeunotomy was performed by intussuscepting end-to-end anastomosis with an internal stent. Amylase level of the drain fluid was checked every 2 days (postoperative 1, 3, 5, 7 day). Synthetic somatostatin was infused postoperatively for 7 days. RESULTS: The mean age of the 51 patients was 64.8 years, and the male to female ratio was 1.4: 1. The classification by pathologic diagnoses were 20 cases of common bile duct cancer (39%), 19 cases of pancreas head cancer (38%), 6 cases of chronic pancreatitis (12%), 4 cases of ampullar of Vater cancer (8%), and 2 cases of duodenal cancer (4%). There were 24 (47%) postoperative complications. Of these complications, the most occurring complication was the 5 (10%) cases of delayed gastric emptying. The other complications were 4 (8%) cases of pancreaticojejunostomy leakage, 4 (8%) cases of intraabdominal abscess, wound infection, and pulmonary complications. The patients were divided into a complication group related to pancreatic leakage and a non-complication group. There were 14 cases allocated to the complication group, and 37 cases were allocated to the non-complication group. The level of amylase in the drain fluid was higher in the complication group (P<0.05). Four cases of pancreaticojejunostomy leakage developed after pancreatoduodenectomy. All cases had symptoms of high fever, leukocytosis, and abdominal tenderness. CONCLUSION: The occurrence of complications related to pancreaticojejunostomy leakage is suspected if the level of amylase in the drain fluid is higher than the normal serum amylase level after 5 days post operation, and fever, leukocytosis, or abdominal tenderness were the typical complication symptoms.
Abscess
;
Amylases*
;
Classification
;
Common Bile Duct
;
Diagnosis*
;
Duodenal Neoplasms
;
Female
;
Fever
;
Gastric Emptying
;
Head and Neck Neoplasms
;
Humans
;
Leukocytosis
;
Male
;
Pancreas
;
Pancreaticoduodenectomy*
;
Pancreaticojejunostomy
;
Pancreatitis, Chronic
;
Postoperative Complications
;
Retrospective Studies
;
Somatostatin
;
Stents
;
Wound Infection
8.Schwannoma in Head and Neck: Preoperative Imaging Study and Intracapsular Enucleation for Functional Nerve Preservation.
Si Hong KIM ; Na Hyun KIM ; Kyung Rok KIM ; Ja Hyun LEE ; Hong Shik CHOI
Yonsei Medical Journal 2010;51(6):938-942
PURPOSE: In treating schwannoma patients, it is critical to determine the origin of the tumor to preserve nerve function. We evaluated the validity of preoperative imaging studies in distinguishing the neurological origin of the schwannomas of the head and neck, and the efficacy of intracapsular enucleation in preserving nerve function. MATERIALS AND METHODS: In 7 cases of schwannomas in the head and neck region, we predicted whether the tumor originated from the vagus nerve or the cervical sympathetic chain through imaging studies including computed tomography (CT) and magnetic resonance imaging (MRI). All patients were performed intracapsular enucleation, and the function of the vagus nerve and the sympathetic nerve was evaluated preoperatively and postoperatively. RESULTS: Preoperative imaging studies showed 6 cases where the tumor was located between the carotid artery and the internal jugular vein, and 1 case where the tumor was located posteriorly, displacing the carotid artery and the internal jugular vein anteriorly. At the time of operation, we confirmed schwannoma originating from the vagus nerve on the first 6 cases, and schwannoma originating from the sympathetic nervous system on the last case. All patients went through successful intracapsular enucleation, and of the seven schwannoma cases, 6 patients maintained normal postoperative neurological function (85.7%). CONCLUSION: Preoperative imaging studies offer valuable information regarding the location and origination of the tumor, and intracapsular enucleation helped us to preserve the nerve function.
Aged
;
Diagnostic Imaging/methods
;
Female
;
Follow-Up Studies
;
Head and Neck Neoplasms/complications/diagnosis/*pathology
;
Humans
;
Magnetic Resonance Imaging/methods
;
Male
;
Middle Aged
;
Neurilemmoma/complications/diagnosis/*pathology
;
Peripheral Nervous System/injuries/physiology
;
Sympathetic Nervous System/physiology
;
Tomography, X-Ray Computed/methods
;
Treatment Outcome
;
Vagus Nerve/physiology
9.Imaging diagnosis of and surgical approach to parapharyngeal space tumors.
Shan-ting LIU ; Wei DU ; Lu FENG ; Peng LI ; Ming ZHAO
Chinese Journal of Stomatology 2013;48(5):308-310
Adenoma, Pleomorphic
;
diagnosis
;
diagnostic imaging
;
surgery
;
Adolescent
;
Adult
;
Aged
;
Angiography, Digital Subtraction
;
Carcinoma, Adenoid Cystic
;
diagnosis
;
diagnostic imaging
;
surgery
;
Chemotherapy, Adjuvant
;
Child
;
Female
;
Follow-Up Studies
;
Head and Neck Neoplasms
;
diagnosis
;
diagnostic imaging
;
surgery
;
Humans
;
Magnetic Resonance Imaging
;
Male
;
Middle Aged
;
Neurilemmoma
;
diagnosis
;
diagnostic imaging
;
surgery
;
Oral Surgical Procedures
;
methods
;
Postoperative Complications
;
Radiotherapy, Adjuvant
;
Tomography, X-Ray Computed
;
Young Adult
10.Risk factors and etiology of surgical site infection after radical neck dissection in patients with head and neck cancer.
So Yeon PARK ; Mi Suk KIM ; Joong Sik EOM ; Jin Seo LEE ; Young Soo RHO
The Korean Journal of Internal Medicine 2016;31(1):162-169
BACKGROUND/AIMS: Surgical site infection (SSI) is a major complication after radical neck dissection (RND) in patients with head and neck cancer (HNC). We investigated the incidence, risk factors, and etiology of SSI among patients who underwent RND. METHODS: A retrospective cohort study was performed on HNC patients, excluding those with thyroid cancer, who underwent first RND at a teaching hospital between January 2006 and June 2010. Medical records were collected and analyzed to evaluate the risk factors and microbiological etiologies. RESULTS: A total of 370 patients underwent first RND. The overall incidence of SSI was 19.7% (73/370). Multivariate analysis showed that male sex (odds ratio [OR], 4.281; p = 0.004), cardiovascular diseases (OR, 1.941; p = 0.020), large amount of blood loss during surgery (OR, 4.213; p = 0.001), and surgery lasting longer than 6 hours (OR, 4.213; p = 0.002) were significantly associated with SSI. The most common causative pathogen was Staphylococcus aureus (32.6%), and 93.2% of S. aureus isolates were methicillin-resistant. Klebsiella pneumoniae (13/92, 14.1%), Pseudomonas aeruginosa (11/92, 12.0%), and Enterococcus species (11/92, 12.0%) were also frequently detected. CONCLUSIONS: Based on our results, we predict that certain groups of patients are at high risk for SSIs after major HNC surgery. Preventive measures or close monitoring in these patients may be required to reduce the likelihood of postoperative SSIs. Furthermore, even though additional research is required, we would consider changing the prophylactic antibiotic regimens according to the causative organisms.
Aged
;
Bacteriological Techniques
;
Blood Loss, Surgical
;
Cardiovascular Diseases/complications
;
Chi-Square Distribution
;
Female
;
Head and Neck Neoplasms/*surgery
;
Humans
;
Incidence
;
Logistic Models
;
Male
;
Medical Records
;
Middle Aged
;
Multivariate Analysis
;
Neck Dissection/*adverse effects
;
Odds Ratio
;
Operative Time
;
Republic of Korea
;
Retrospective Studies
;
Risk Factors
;
Sex Factors
;
Surgical Wound Infection/diagnosis/epidemiology/*microbiology
;
Treatment Outcome