Sialosyl Tn mucin antigen (STn) is a carbohydrate antigen of tumor associated mucin formed by the premature 2~6 sialation of N-acetylgalactosamine. STn has been expressed in several tumor types and showed prognostic significance in colonic carcinoma. The authors evaluated the expression of STn immunohistochemically and correlated its expression with clinicopathologic variables in 100 gastric cancers. In early gastric cancer, STn was expressed in 24 cases out of 50 cases (48%). In advanced gastric cancer, STn was expressed in 48 of 50 (96%). The difference in STn expression between advanced gastric cancer and early gastric cancer was statistically significant. The difference in STn expression between tumors with lymph node metastasis and those without lymph node metastasis, between tubular adenocarcinoma and signet ring cell carcinoma, and between intestinal type and diffuse type adenocarcinoma was statistically insignificant in early or advanced gastric adenocarcinoma. These results suggest that the STn expression plays a role in the tumor progression in both early and advanced gastric adenocarcinomas.
Adenocarcinoma* ; Carcinoma, Signet Ring Cell ; Colon ; Lymph Nodes ; Mucins* ; Neoplasm Metastasis ; Stomach ; Stomach Neoplasms

Most ectopic pregnancies occur in the fallopian tubes. There have been numerous theories to explain the occurrence of ectopic pregnancy in fallopian tubes. The most commonly held view is that the passage of the fertilized ovum through the fallopian tube is delayed or hindered by chronic inflammation and its sequelae. We designed a study to evaluate the details of histopathologic changes and the location of implantation and how they relate to the clinical history. 182 fallopian tube specimens from patients who had undergone total or partial salpingectomy were examined. A high incidence of non-specific inflammation of plicae and wall of tube (31.9%) and salpingitis isthmica nodosa (12.6%) were observed. Other associated findings included acute salpingitis, complex plicae or complex hyperplasia of tubal epithelium, fibrous adhesion with ovary, endometriosis, and calcification. History of previous ectopic tubal pregnancy was found in 8 cases. The cases with serum beta-HCG value above 2,500 I.U./L (group I, n=97) were more frequently noted in those exhibiting myosalpingeal invasion of trophoblast (67 cases) than in those without invasion (30 cases). Of the 182 tubal pregnancies, 117 (64.3%) cases were found in the ampulla and 47 (25.8%) cases in isthmic location. In 117 ampullary pregnancies, the products of conception were found intraluminally in 71 cases (60.7%), and extraluminally in 34 (29.1%) cases, of which the products of conception were found entirely extraluminal. The products of conception, found both within and outside the tubal lumen, were found in 12 cases (10.2%). Of 47 tubes with isthmic pregnancies, 33 cases were intraluminal (70.2%), 12 cases were extraluminal (25.5%), and two cases were mixed (4.3%). In conclusion, significant histopathologic abnormalities accompany a majority of ectopic tubal pregnancy, and myosalpingeal invasion of trophoblast is correlated with high serum beta-HCG. Thus, it is necessary to confirm not only the ectopic placental tissue but also the accompanying details of the other histopathologic findings or the pathologic evaluation of ectopic tubal pregnancy.
Endometriosis ; Epithelium ; Fallopian Tubes ; Female ; Fertilization ; Humans ; Hyperplasia ; Incidence ; Inflammation ; Ovary ; Pregnancy ; Pregnancy, Ectopic ; Pregnancy, Tubal* ; Salpingectomy ; Salpingitis ; Trophoblasts ; Zygote

No abstract available.
Leukemia, Erythroblastic, Acute* ; Myelodysplastic Syndromes*

Familial juvenile polyposis is a rare intestinal polyposis characterized by the occurrence of multiple juvenile polyps in the gastrointestinal tract. We report a case of familial juvenile polyposis in a 17-year-old man with a review of the literature. This patient underwent total colectomy due to a 6 years history of rectal bleeding. Grossly, the colon showed 36 variable sized pedunculated polyps, measuring 2.5cm x 2cm from the largest size and 0.2cm x 0.2cm to the smallest size. Histologically, the polyps consisted of cystically dilated glands, lined by normal colonic epithelial cells, scattered in loose, edematous stroma containing inflammatory cell infiltration. There were no areas of tubular adenoma or malignancy in any of the polyp.
Adenoma ; Adolescent ; Colectomy ; Colon ; Epithelial Cells ; Gastrointestinal Tract ; Hemorrhage ; Humans ; Intestinal Polyposis ; Polyps

The small scale industries in Korea are important in occupational health care management due to high accident rate and poor working condition. The authors surveyed the 4,811 small scale industries participated in the 1997 subsidiary program on health care management. The contents of survey were the general characteristics of the factory, the results of workers' general and occupational health examination, the results of workplace environmental monitoring, and the number of occupational accident and injured person at 1995 and 1996. We classified all industries by 67 groups. The prevalence of the general disease was higher in 'Manufacture of other fabricated metal productsj. rManufacture of textiles', 'Manufacture of basic metalsj. In occupational disease, that was higher in FManufacture of metal products', 'Manufacture of basic metals', so in environmental monitoring in 'Manufacture of textiles', 'Manufacture of other fabricated metal products' 'Printfrig' in occupational injuries in 'Manufacture of chemical products', 'Manufacture of basic metals'. However the factories of 'manufacture of motor vehicle', 'manufacture of machine and equipment', 'manufacture of electric product' in the program are large in magnitude, but less important in occupational health management. We observed that the prevalence of general disease, occupational disease, workplace environmental monitoring, occupational injuries of subsidized industries in 1996 were increased compared with those in 1995. and were larger than those of nationwide statistics. These phenomenon shows that the subsidiary health program for participated industries is important and to be urgent. We observed that the major groups in district were different and so the approaching method of each district must be various and different. And the health program manager should focus on the C grade in health examination and the action level in workplace monitoring more than the D grade and the permissible level.
Accidents, Occupational ; Delivery of Health Care* ; Environmental Monitoring ; Humans ; Korea ; Occupational Diseases ; Occupational Health* ; Occupational Injuries ; Prevalence

No abstract available.
Health Promotion*

No abstract available.
Chronic Disease* ; Risk Factors*

PURPOSE: This study attempted to understand health behaviors and analyze the association of the health behaviors with musculoskeletal diseases in adults. METHOD: The subjects of this study were 6,946 adults aged between 20 and 65 who had participated in the 2001 National Health Nutrition Survey. The instrument was composed of Health Interview Survey (HIS), Health Behavior Survey (HBS) and Health Examination Survey (HES), which were used in the 2001 National Health Nutrition Survey. Data were analyzed using SPSS 10.1 by applying chi2 and multivariate logistic regression. RESULTS: 1. The present smoking rate was 46.5% and the present drinking rate was 81.2%. 2. Of the subjects, 22.7% were overweight (BMI> or =25), and 28.1% were exercising regularly. 3. Major factors affecting musculoskeletal diseases were low education, poor economic state, smoking, and BMI. Middle school graduates were 2.54 times more likely to have musculoskeletal diseases than college graduates. The risk was 1.83 times higher in indigent respondents than in affluent ones, and 1.43 times higher in smokers than in non-smokers. CONCLUSION: Therefore, in order to reduce musculoskeletal diseases in adults, other various factors should be looked into, and public education about appropriate posture and exercise should be carried out in community. Additionally, concentrated intervention programs for patients with musculoskeletal diseases should be performed.
Adult* ; Surveys and Questionnaires ; Drinking ; Education ; Health Behavior* ; Humans ; Logistic Models ; Musculoskeletal Diseases* ; Nutrition Surveys ; Overweight ; Posture ; Poverty ; Smoke ; Smoking

PURPOSE: This study was conducted to get baseline data to establish a guideline for the infant nutrition by observing the feeding practice and nutritional intake during infancy and evaluationg the nutritional status of iron and lipids at 12-month-old infants. METHODS: This survery was cnducted from July to November, 1992. Subjects were healthy infants who were brought to Yeungnam University Hospital for vaccination. We followed up feeding methods for 6 months in 120 infants, and laboratory tests which include hemoglobin, fematocrit, MCHC, ferritin, total cholesterol, HDL-cholesterol, triglyceride and urea nitrogen/creatinine ratio were done in 36 infants at 12 months of age. RESULTS: Male to female sex ratio was 1.6:1 in total 120 study infants. Among 36 infants who took laboratory tests, five infants were breast-fed, 25 were formula-fed, and 6 were mexed-fed. Percentage of the formula-fed infants increased as their monthly age increases. Although 54.2% of the studied infants were started weaning diet at four months of age, 10.8% of infants were not given any weaning diet until 6 month of age. Breastfed infnats had lower hemoglobin(10.6+/-1.8g/dl), hematocrit(32.6+/-3.6%), serum ferritin(13.6+/-13.1ng/ml)(p<0.05), and 15.6% of them had anemia and 16.7% of them had iron deficiency. Serum lipids levels except total cholesterol in breaset-fed female infants were comparable between groups. CONCLUSIONS: We confirm that the incidence of iron deficiency anemia was increased in breast fed infants and there was no difference in lipids levels according to different feeding methods. Adequate iron supplementation through weaning diets is one of the most important problems in breast milk feeding
Anemia ; Anemia, Iron-Deficiency ; Breast ; Cholesterol ; Diet ; Feeding Methods ; Female ; Ferritins ; Humans ; Incidence ; Infant* ; Iron* ; Male ; Milk, Human ; Nutritional Status* ; Sex Ratio ; Triglycerides ; Urea ; Vaccination ; Weaning

PURPOSE: The study was designed to verify effects of aromatherapy on depression, anxiety and the autonomic nervous system in breast cancer patients who are undergoing adjuvant radiotherapy. METHODS: Data were collected from November 2006 through March 2007 at the C university hospital in Seoul. The study included 33 patients and they were assigned to three groups. Group I had aroma oil inhalation for 2 minutes per time, three times a day for six weeks whereas Group II and a control group inhaled aroma oil for 2 minutes per time, once a day for six weeks. For Groups I and II, a mixture of lemon, lavender, rosewood and rose essential oils were used while control group inhaled tea tree oil. RESULTS: Depression was significantly decreased in patients in the experimental groups only. In Groups I and II patients, anxiety level was lower than that in control patients. Patients in Groups I and II also showed stronger physical resistance to stress than control group patients. CONCLUSION: Aromatherapy should be considered as a method that can significantly decrease depression in breast cancer patients who are undergoing adjuvant radiotherapy.
Anxiety ; Aromatherapy ; Autonomic Nervous System ; Breast ; Breast Neoplasms ; Depression ; Humans ; Inhalation ; Lavandula ; Oils, Volatile ; Radiotherapy, Adjuvant ; Tea