1.Clinical studies of immunofunction and protein metabolism by combined supplementation of glutamine and recombinant human growth hormone in postoperative patients with cardiogenic cachexia of rheumatic heart disease
Wei WANG ; Wei WU ; Ping HE ; Haidong WANG ; Kang YANG
Journal of Endocrine Surgery 2009;3(2):116-119
Objective To study the effects of recombinant human growth hormone(rhGH) on the treatment for valve replacement postoperative in rheumatic heart disease associated cardiac eaehex.Methods Fortytwo patients with rheumatic heart disease associated cardiac eachexia were divided into two groups.Group one(n=20,rhGH group) received standard enteral nutrition (15 kal·kg-1 · d-1)with rhGH 10U injection subeutaneously from postoperation day 7 to day 14 and group two(n = 22,eontrol group) received standard enteral nutrition (15 kal·kg-1· d-1) for the same period.Haemoglobin, serum total protein, serum albumin, blood glucose, handgrip exercise and triceps skin_fold thickness were determined.Meehanieal ventilation, hypostatie pneumonia incidence rate, and length of stay were observed.Results The levels of serum total protein, serum albumin and blood glucose eoneentration in the rhGH group at the 14th day were inereased significantly compared to that in the control group(P <0.01).Haemoglobin, triceps skinfold thiekness and handgrip exercise in rhGH group were significantly different from those in the control group(P <0.05).Postoperative meehanieal ventilation time, intensive care unit time, hospital stay time were signifieantly shorter than those in the eontrol group (P < 0.05), and hypostatie pneumonia was significantly lower than that in the eontroi group(P < 0.01).Conclusions The rhGH can obviously improve anabolie effects of patients with rheumatic heart disease associated cardiac eachexia whieh can reduce hypostatie pneumonia and shorten postoperative hospital stay time.
2.Effect of potassium magnesium aspartate on arrhythmia and heart function in valve replacement postoperative patients of rheumatic heart disease
Wei WANG ; Wei WU ; Ping HE ; Haidong WANG ; Kang YANG
Journal of Third Military Medical University 2003;0(23):-
Objective To evaluate the curative effect of potassium magnesium aspartate on arrhythmia and heart function in valve replacement postoperative patients of rheumatic heart disease. Methods Two hundred and eighty patients with rheumatic heart disease were divided into 2 groups in random,with no statistical significance. Treatment group (n=155) were received i.v. potassium magnesium aspartate 40 ml every day and control group (n=125) were only given conventional therapy. At the same time they were given same treatment. Blood magnesium level,blood potassium levels,arrhythmia incidences and heart function were also observed. Results Blood magnesium and potassium levels of the treatment group were higher than those of the control group (P
3.Efficacy of hysteroscopic guiding endometrial resection on dysfunctional uterine bleeding and its influence factors
Xiumei LIU ; Wei HE ; Xiuyan WANG
Clinical Medicine of China 2014;30(5):556-558
Objective To investigate the efficacy and influence factors of hysteroscopic guiding endometrial resection on dysfunctional uterine bleeding.Methods One hundred and eighty women with dysfunctional uterine bleeding were selected as our subjects in Maternal and Child Health Hospital of Qinhuangdao from Jan.2009 to Jan.2011.One hundred and fifty which meet with operation indications underwent hysteroscopic guiding endometrial resection.Operation periods,blood loss,adverse effects rate were recorded.Serum follicle stimulating hormone (FSH),luteinizing hormone (LH),estradiol (E2) and progesterone (P) hormone levels were detected at preoperative and postoperative.The efficacy was recorded at 6 and 12 months after the procedure.Results The average operation time and amount of bleeding were (31.2 ± 11.0)min and (32.3 ± 10.5) ml,and no blood transfusion performed during the operation.All cases got the succeed operation.There were no significant difference in terms of serum FSH,LH,E2 and P concentrations before and after treatment(P >0.05).At 6 months after treatment,improvement rate was 64.0% (96/150),and effective rate was 32.0% (48/150).The total effective rate was 96.0% (144/150).At 12 months after treatment,the improvement rate was 58.0% (87/150),effective rate was 36.0% (54/150).The total effective rate was 94.0%(141/150).There was significant different in terms of total effective rate between 6 months and 12 months after treatment(x2 =113.6,P > 0.05).Postoperative complications occurred in 2 cases,including 1 cases of abdominal pain,and 1 cases of dysmenorrhea.Uterine cavity depth,age and disease duration were the main factors affect the clinical efficacy.(OR(95 % CI):-1.14 (-1.17 to-1.07),1.60 (1.31 to 2.08),-1.02(-1.14 to-1.08),P < 0.05).Conclusion Treatment of hysteroscopic guiding endometrial resection on dysfunctional uterine bleeding is proved to be efficacy due to the less adverse reaction.
4.Research Progress in molecular mechanisms between RSUME and invasive pituitary adenoma
Wei HE ; Dapeng WANG ; Xiaoli SHEN
Chinese Journal of Clinical Oncology 2014;(14):942-944
Pituitary adenoma, a benign intracranial tumor, is the third most common brain tumor, second only to glioma and me-ningioma. Pituitary adenoma has been defined as a benign tumor, but some pituitary adenomas can invade the surrounding tissue. This tumor is difficult to resect and can easily recur after surgery. RWD-containing sumoylation enhancer (RSUME) can stabilize the activity of hypoxia-inducible factor-1α and inhibitor kappaB by the small ubiquitin-related modifiers. This phenomenon indicates the impor-tance of RSUME in pituitary adenoma because it promotes the invasiveness of the tumor. However, the correlation between RSUME and the invasion of pituitary adenoma remains unclear. In this study, the roles of RSUME on HIF-1α/VEGF signaling pathway and IκB/NF-κB compomers in the invasiveness of pituitary adenoma were reviewed.
5.On personal career guidance
Bangtian WANG ; Ping WEI ; Feiying HE
Chinese Journal of Medical Education Research 2006;0(07):-
Personality is a key factor that affects someone's professional success.Different people have different characteristic,and each profession demands particular personality.The essay will settle the problem of how to carry out the personal career guidance to fully develop students' potential and their strong suits,by taking into account the fact that students truly need the diversity development.
6.Progress of derived traditional Chinese medicine in treatment of Alzheimer disease
Wei CAO ; Xiaoyan WANG ; Xiaobo HE
Chinese Journal of Biochemical Pharmaceutics 2015;35(10):183-188
Alzheimer disease (AD) is a significant threat on health in elderly people.Many traditional Chinese herbs and their prescriptions show fairly good effect in treatment of AD.We review the results on treatment of AD from three aspects of AD' s pathogenesis, in which the natural herbs were mainly used, and present the way to the problem to be solved.
7.Photodynamic therapy for choroidal neovascularization in age-related macular degeneration
Shouzhi HE ; Xiaoling LI ; Wei WANG
Chinese Journal of Ocular Fundus Diseases 2001;0(03):-
Objective To evaluate short term effects of a single photodynamic therapy (PDT) treatment with visudyne (CIBA Vision Corp.) for choroidal neovascularization (CNV) in age ralated macular degeneration (AMD). Methods Thirty cases (35 eyes) diagnosed as AMD patients with classic CNV were treated with PDT. The data of visual acuity testing, fluorescein angiography (FFA), indocyanine green angiography (ICGA) and optic coherence tomography (OCT) were used to evaluate the effects of a single treatment of PDT before and 1 week, 1 ,3 month after treatment. Results The visual acuity of 34 eyes were stable or improved in 3 months follow up;and the visual acuity of 1 eye was decreased. Decrease or dispearance of fluorescein leakage from CNV was noted in 19 eyes. No serious complication occurred. Conclusion Single treatment of PDT for CNV in AMD can achieve short term decrease or cessation of fluorescein leakage from CNV without loss of visual acuity.
8.Effect of Tangnaoluotong Combined with Intravenous Low Intensity Laser Irradiation on Blood Rheology and Endothelin of Diabetes Mellitus and Cerebral Infarction Patients
Bo WANG ; Ke HE ; Haifeng WEI
Chinese Journal of Information on Traditional Chinese Medicine 2006;0(03):-
Objective To observe the effect on the patients of diabetes mellitus and cerebral infarction in terms of level of blood rheology and endothelin after using both intravenous low intensity laser irradiation (ILILI) and traditional Chinese medicine Tangnaoluotong in the treatment. Method Ninety patients of diabetes mellitus and cerebral infarction, having the symptom of deficiency in both vital energy and yin with blood stasis, were divided into three treatment groups at random:ILILI group (A), TCM treatment group (B), and a group with compound treatment of ILILI and TCM (C). The level of blood rheology and endothelin were observed after 1 month’s treatment. Result Compared with group A and group B, group C could significantly reduce the level of fibrinogen and endothelin, improve the deformed ability of RBC. Conclusion ILILI with Tangnaoluotong can significantly alter the blood rheology and endothelin on the patients of diabetes mellitus and cerebral infarction, which result in a better curative effect.
9.Design and application of imbedded DBS
Jingang WANG ; Xiaobo SHI ; Wei HE
Chinese Medical Equipment Journal 2004;0(08):-
Parkinson's disease is a kind of familiar diseases troubling old people in China.It's recognized internationally that DBS is the best method to control Parkinson's disease.This paper designs a kind of DBS without internal electrical source,which can greatly decrease the treatment cost for Parkinson's disease.The structure,circuit philosophy and experiments on rats are also mentioned.
10.Surgical treatment of ankle joint fracture and rehabilitation
Xilong LIN ; Wei HE ; Yanfeng WANG
Orthopedic Journal of China 2006;0(06):-
[Objective]To evaluate the surgical techniques,rehabilitation and the results of internal fixation performed for ankle joint fracture.[Method]One hundred and twenty-six patients with ankle joint fractures were treated with open reduction and internal fracture. According to the Danis-Weber classification,there were 12 cases of type A, 86 cases of type B, 28 cases of type C.The follow-up interview period varied from one year to five years,with an average of eighteen months.[Result]The number of patients whose results was better, good, fair and poor was 65, 44, 11 and 6.The total percent-age of good to better clinical results was 86.51%.[Conclusion]Operative treatment and rehabilitation may provide satisfactory fracture reduction and clinical results for ankle joint fracture.The opportunity selection,correct fracture pattern estimation, proper internal fixation and rehabilitation are important to achieve better long term results.