Objective To investigate the changes of serum C reactive protein (CRP), Interleukin-2 (IL-2), Monocyte chemoattractant protein-1 (MCP-1) and hemorheology in patients with pelvic inflammatory disease. Methods Eighty patients with pelvic inflammatory disease were enrolled as observation group from May 2013 to May 2015, 60 healthy women in the same age were selected as control group at the same period. The serum CRP, IL-2, MCP-1 and hemorheology were compared between observation group and control group;the detection indexes were compared in patients with mild, moderate and severe pelvic inflammatory disease in observation group. Results The serum levels of CRP and MCP-1 and hemorheology of observation group were higher than those of control group, the differences were statistically significant (P<0.05) . The detection indexes of patients with severe pelvic inflammatory disease were higher than those of mild and moderate pelvic inflammatory disease, the detection indexes of patients with moderate pelvic inflammatory disease were higher than those of mild pelvic inflammatory disease, the differences were all statistically significant (P<0.05) . The level of IL-2 of was significantly lower than that of control group, the level of IL-2 of patients with severe pelvic inflammatory disease was lower than that of mild and moderate pelvic inflammatory disease, the level of IL-2 of patients with moderate pelvic inflammatory disease was significantly lower than that of mild pelvic inflammatory disease, the differences were all statistically significant ( P<0.05) . Conclusion The serum levels of CRP, IL-2, MCP-1 and hemorheology of patients with pelvic inflammatory disease have significant changes, and the detection indexes of patients with mild, moderate and severe pelvic inflammatory disease have significant differences.

Adult ; Benzene ; toxicity ; Bone Marrow ; drug effects ; pathology ; Bone Marrow Cells ; Humans ; Leukemia, Monocytic, Acute ; chemically induced ; pathology ; Male

Objective To investigate the effects of propofol combined with remifentanil on he-patic ischemia-reperfusion injury in cirrhotic rats.Methods Sixty male SD rats of 260 to 300 grams were randomly divided into five groups(n=12):the sham-operated group(group S);the model con-trol group (group M);propofol group (group P);remifentanil group (group R);propofol combined with remifentanil group (group PR).In group M,P,R,PR,the hepatic arteries and veins of middle and left lobes were occluded for 20 min after 1 w hepatocirrhosis by using four principal factors,and group S went through an open surgery only.In groups P,R,and PR,porpofol (at a rate 20 mg·kg-1 ·h-1 for 1 h)、remifentanil (at a rate 1 μg·kg-1·min-1 for 1 h)and porpofol (at a rate 20 mg·kg-1· h-1 )combined with remifentanil(at a rate 1 μg·kg-1·min-1 for 1 h)was infused iv at 10 min before is-chemia,respectively.In group M,normal saline was infused iv at the same rate.Blood samples were taken at the end of 4 h reperfusion to determine serum AST,ALT activity.Meanwhile liver specimens were collected to assess Bcl-2 and Bax protein expression in liver cell and measuring the apoptosis in-dex(AI)of hepatic cell.The pathological change of liver was also examined.Results Compared with group S,the activity of AST,ALT,the expression of Bcl-2 and Bax and the apoptosis index(AI)of hepatic cell of the other groups all increased significantly(P <0.05);Compared with group M,the expression of Bcl-2 of groups P,R,PR significantly increased,and the activity of AST,ALT,the ex-pression of Bax and the apoptosis index(AI)of hepatic cell significantly decreased(P <0.05 );Com-pared with groups P and R,the expression of Bcl-2 of group PR significantly increased,and the activ-ity of AST,ALT,the expression of Bax and the apoptosis index(AI)of hepatic cell significantly de-creased(P <0.05);Microscopy and scanning electron microscopy showed that,for groups P,R,PR, pathological injury of liver tissue significantly reduced compared with group M.Conclusion Propofol combined with remifentanil can reduce the hepatic ischemia-reperfusion injury in cirrhotic rat by regu-lating Bcl-2 and Bax protein expression and inhibiting apoptosis.The effect is much more enhanced when they are used in combination than individuals.

Objective To observe the clinical efficacy and adverse reactions of desogestrel ethinylestradiol in the treatment of dysfunctional uterine bleeding ( adolescent Dub ) .Methods 86 cases with adolescent functional bleeding were divided into the treatment group and control group ,43 cases in each group .The control group received conjugated estrogen(Premarin) treatment,the treatment group was given desogestrel ethinylestradiol treatment .The hemostatic effect and drug adverse reaction of the two groups were observed .Results The cure rate of the treatment group was 65.1%,that in the control group was 23.3%,there was significant difference between the two groups (χ2 =15.28,P<0.01).The hemostatic time of the treatment group was (33.24 ±12.85)h,which was shorter than (50.31 ± 16.32)h of the control group (t=5.39,P<0.05).The incidence rate of adverse reactions between the two groups had no significant difference (χ2 =0.49,P>0.05).Conclusion Desogestrel ethinylestradiol in the treatment of ado-lescent functional bleeding has exact curative effect ,it has low incidence of adverse reactions and better acceptance .

Objective To study the clinical and endoscopic features of Gastric mucosa－ associated lymphoid tissue(MALT) lymphoma. Methods Clinical and endoscopic data of thirty two patients with gastric MALT lymphoma diagnosed pathologically after opration were analyzed. Results Patients with gastric MALT lymphoma had a median age of 51.3years with male predominance and a bimodal age distribution pattern, aged 30～ 39 and 60～ 69 years respectively. The symptoms were not characteristic.The tumor originated from antrum in 12 cases,corpus in 8 and multifocal lesions were found in 12 instances. The tumor appeared infilitrative in 12, ulcerative in 16 and nodular in 6 patients endoscopically. Lymphatic metastasis was detected in infiltrative type, before the serosa was involved. Immunohistochemistry showed B－ cell lymphoma in all the 32 cases.And Helicobacter pylori(H.pylori) infection was found in 27 cases(84.4％ ).Nocorrelation was found between endoscopic types and manifestations.Metastasis to local lymph nodes was found early in infiltrative tumor.Conclusions It is suggested that H.pylori infection may play a role in the pathogenesis of gastric MALT lymphoma.

Objective To evaluate and compare the therapeutic effects of the open prostatectomy(OP)?transurethral electrovaporization ablation prostatectomy (TUEVAP) and interstitial laser coagulation(ILC) for the treatments of symptomatic BPH. Methods 282 symptomatic BPH patients randomly underwent OP (n=98)?TUEVAP(n=91) or ILC(n=93) respectively and the therapeutic effects were evaluated. Results There are significant improvements in symptoms and physical signs in each group after the procedure.The average catheterization time following OP?TUEVAP and ILC was 185 h?76 h and 362 h,the immediate morbidity rate being 28.9%?16.7%? 14.8 % and the retreatment rate 1.0%?6.6% and 16.1% respectively. OP group showed the longest average operative time and the most blood loss both of which were the least in ILC group. Conclusions OP is the most effective of the three procedures, but the trauma to the patient is the most.The therapeutic effect of TUEVAP is similar to OP's,with less injure.ILC is the easiest and safest procedure with the least side effects.

Objective To study the changes of liver blood flow with or without portal vein thrombus (PVTT) in hepatocellular carcinoma. Methods The hepatocellular carcinoma patients with PVTT (n=26) and without PVTT (n=35) were enrolled. The diameter and the velocity of hepatic arterial (HA) and portal vein (PV) were measured with color Doppler flow imaging in all patients. Results In the patients with PVTT, the diameter of PV dilated and the velocity of PV dropped significantly and the velocity of HA rised obviously, as compared with those without PVTT. Conclusion The index of HA and PA is very important to guide the therapy of hepatocellular carcinoma.

[Objective]To evaluate the surgical techniques,rehabilitation and the results of internal fixation performed for ankle joint fracture.[Method]One hundred and twenty-six patients with ankle joint fractures were treated with open reduction and internal fracture. According to the Danis-Weber classification,there were 12 cases of type A, 86 cases of type B, 28 cases of type C.The follow-up interview period varied from one year to five years,with an average of eighteen months.[Result]The number of patients whose results was better, good, fair and poor was 65, 44, 11 and 6.The total percent-age of good to better clinical results was 86.51%.[Conclusion]Operative treatment and rehabilitation may provide satisfactory fracture reduction and clinical results for ankle joint fracture.The opportunity selection,correct fracture pattern estimation, proper internal fixation and rehabilitation are important to achieve better long term results.

The implant-supported prosthesis has gradually become the preferred treatment for patients with partial edentulous or complete edentulous. Causes for the implant failure have been discussed in the majority of studies conducted in recent years, while their risk factors are still controversial. Patient factors (gender, age, smoking, osteoporosis, diabetes, medication, periodontitis and bruxism), clinical parameters (implant area, bone quality, implant size) and doctor factors (surgical-related factors, prosthesis-related factors) will all affect implant failure. This article presents typical clinical cases and reviews the potential risk factors for dental implant failure, in order to provide guidance for clinical practice.

Objective To explore the effect of internet + continuing nursing education teaching methodflipped classroomin the teaching of Assessment of Consciousness among junior nurses. Methods A total of 98 nurses who have graduated within two years in the third hospital of Mianyang city in Sichuan province were selected and divided into experimental group and control group by random digits table method with 49 nurses each. The experimental group used flipped classroom teaching method and the control group used the traditional teaching method. After the training, the scores of examination and nurses′ learning satisfaction were analyzed and compared. Results The scores of nurses′ learning satisfaction in the experimental group was (100.35 ± 12.21) points, learning process, learning content, learning result, learning environment, interpersonal relationship of the dimensions were (26.85 ± 3.38), (22.02±3.07), (20.90±3.15), (17.19±2.50), (13.40±1.51) points. The scores of nurses′learning satisfaction in the control group was (86.00±11.63) points, learning process, learning content, learning result, learning environment, interpersonal relationship of the dimensions were (23.63±2.81), (19.67±3.06), (17.76±3.32), (15.20±2.46), (9.74±2.74) points. There were statistical differences between two groups(t=3.46-7.97, all P=0.000). The score of nurses′examination in the experimental group was (78.19±6.11) points,the score of nurses′ examination in the control group was (49.64 ± 14.42) points, and there was statistical difference between two groups(t=10.19, P=0.000). Conclusions Internet+continuing nursing education teaching methodflipped classroomcan improve junior nurses′learning satisfaction and the effect of the training, worthy of further promotion.