1.Clinical research on application of adjustable sutures in glaucoma filtering operation
International Eye Science 2014;(10):1868-1870
AIM:To discuss the application effect of adjustable sutures in glaucoma filtering operation after trabecular resection.
METHODS: Seventy-eight cases ( 101 eyes ) suffered from glaucoma were randomly divided into two groups, observation group and control group. Thirty-nine cases ( 51 eyes ) in the observation group underwent trabeculectomy with adjustable sutures, the control group (39 cases, 50 eyes) only adopted trabeculectomy.RESULTS: Compared Preoperative IOP in two groups, the difference was not statistically significant (P>0. 05). After 6mo, IOP were decreased compared with preoperative in two groups, and that in observation group was lower than control group, the difference was statistically significant ( P < 0. 05 ). Six months after operation, there were 1 eye with shallow anterior chamber Ⅰ and 2 eyes with non- functional bleb in observation group, and the complication rate was 5. 9%. While there were of 6 eyes with shallow anterior chamber, in which 4 eyes at gradeⅠ, each one at gradeII and Ⅲ. Non-functional blebs in 5 eyes and a scleral flap adhesion complications rate in the control group was 24. 0%, significantly higher than that in the observation group, the difference was statistically significant ( P<0.01).
CONCLUSION: The adjustable sutures combined with trabeculectomy for glaucoma can significantly reduce the postoperative complications. The curative effect is exact and clinically applicable.
3.Expression of muscarinic cholinergic receptor 3 in small cell lung cancer and its clinical sig-nificance
Hua HE ; Ailing MA ; Shuxiang ZHANG
Chinese Journal of Clinical and Experimental Pathology 2014;(11):1237-1241
Purpose To investigate the expression of muscarinic cholinergic receptor 3 (M3R) in small cell lung cancer (SCLC) and the correlation between it and clinical characteristics of SCLC. Methods The M3R expression was examined in 60 SCLC patients ad-mitted using immunohistochemistry. The patients were evaluated by clinical history, physical examination and chest CT. Survival time was got through telephone follow-up. Results The M3R expression in primary SCLC tissues was higher than that in normal lung tis-sues. The M3R expression had no difference between limited-disease and extensive-disease of SCLC. There was no correlation between M3R expression and age, gender, lymph node metastasis. The M3R expression was significantly correlated with smoking history. The survival time of M3R negative patients was longer than that of M3R positive patients in Kaplan-Meier survival curve. Conclusion The M3R expression in primary SCLC tissues was higher than that in normal lung tissues. M3R expression had some correlation with prog-nosis of SCLC patients.
4.Design of new multi-channel EEG signal acquisition system
Dongjun XU ; Weixing HE ; Hua ZHANG
Chinese Medical Equipment Journal 1993;0(06):-
A new multi-channel EEG signal acquisition system,which adopts Cypress's EZ-USB FX2 series USB as its micro-controller,is presented in this paper.The system employs AD620 and OP07 at the pre-amplifying stage and the following two amplifying stages respectively.Universal Series Bus(USB) technology is used to realize the real-time recording,displaying and tele-monitoring of EEG signal,which can also be stored in CF card after compression.The USB software developing tool is WinDriver.
5.Zinc and IL-1beta concentration in serum and cerebrospinal fluid in children with febrile seizure.
Chao-Gui ZHANG ; Chang-Hua QU ; Hua YANG ; Wan-Hong LIU ; Xiao-Hua HE
Chinese Journal of Applied Physiology 2013;29(4):344-345
Child, Preschool
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Female
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Humans
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Infant
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Interleukin-1beta
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blood
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cerebrospinal fluid
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Male
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Seizures, Febrile
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blood
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cerebrospinal fluid
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Zinc
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blood
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cerebrospinal fluid
6.Effects of genistein on expressions of jak1 kinase and inteleukin-4 in lung of guinea pigs with bronchial asthma.
Xiu-feng ZHANG ; Zhen-hua HE ; Xiao-wu TAN
Chinese Journal of Applied Physiology 2009;25(3):328-348
Animals
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Asthma
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drug therapy
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metabolism
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Genistein
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pharmacology
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therapeutic use
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Guinea Pigs
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Interleukin-4
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genetics
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metabolism
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Janus Kinase 1
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genetics
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metabolism
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Lung
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metabolism
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Male
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Protein Kinase Inhibitors
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pharmacology
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therapeutic use
7.Key technique of embedded medical video transmission system
Xinghua HE ; Guangwen LU ; Yanwu ZHANG ; Hua WANG
Chinese Medical Equipment Journal 2004;0(09):-
Objective To realize three key techniques in medical video transmission system including the establishment of cross-compilation environment,OSD superposition by drive equipment,the resolve of network delay of MPEG4 video stream.Methods Embedded Linux was used to programming.Results The three key techniques were realized.Conclusion The resolve of key techniques sweeps off the obstacles in the construction of medical video transmission system.
8.MRI Manifestation of Temporomandibular Joint after Trauma
Hua WANG ; Xiaoying WANG ; Yi ZHANG ; Dongmei HE ; Xuexiang JIANG
Journal of Practical Radiology 1991;0(03):-
Objective To investigate MRI manifestations of temporomandibular joint trauma,emphasized on the displacement and deformation of the meniscus.Methods Thirteen patients with TMJ trauma were examined by MRI with 3-inch dual surface coils.T1WI and T2WI images in oblique sagittal and coronal plane were acquired in both closed-and open-mouth positions.Results Twenty(20/26,76.9%) joints had condylar fractures.Nineteen(19/20,95%) discs in 12 patients displaced anteromedially with the condylar fragments,six(6/20,30%) discs showed distortion and deformation.The other one patient had unilateral condylar fracture companied with avulsion and lateral dislocation of ipsilateral disc(1/20,5%),and the opposite disc also showed slight anterior displacement.Effusion was observed in 12(12/20,60%) joints with condylar fractures.The location of the discs didn't show obvious change between closed-and open-mouth positions.Conclusion MRI is an effective method for demonstrating TMJ injuries,and is useful for detecting the changes of morphology and position of the discs.
9.Distractive effect in multiple-object tracking task
Xuemin ZHANG ; Yongna LI ; Li HE ; Hua SHU ; Yuan GAO
Chinese Journal of Tissue Engineering Research 2005;9(44):155-157
BACKGROUND: Research on selective attention of mobile visual information is relatively scarce because of difficulties in technology, methodology and experimental condition control. As is well known, most visual information in the real world is mobile and changeable. To examine the mechanism of mobile visual information is helpful to designing natural and highly efficient human-computer interface as well as selecting specialized personnel in special fields OBJECTIVE: To explore the distractive effect of the number, color, and form changes of distractors on multiple-target tracking performance. DESIGN: The present study was a 3 × 2 × 2 within subject design. Participants were undergraduates from Beijing Normal University.SETTING: Institute of Cognitive Neuroscience and Learning, Beijing Normal University.PARTICIPANTS: The experiment was performed in the Experimental Psychology Lab of Beijing Normal University in April 2003. Twenty-four undergraduates from Beijing Normal University participated in the experiment. Among them there were 11 males and 13 females aged 17-25 years.They all reported normal or corrected-to-normal vision and normal color perception.METHODS: ① Stimuli were presented on a 17-inch Founder monitor with the resolution of 1028 × 800 pixels. A Founder computer controlled the stimulus presentation and randomization of trials. Response latencies were collected by keyboard response with accuracy of one millisecond. The stimuli were randomly moving "日" characters. The number of "日" characters is 4, 8 and 12. As the participants were tracking the objects, the targets would transform to "(│)" and "(│)", and the distractors would change to "(│)" , "(│)", or "H" by removing lines from "日 ". All distractors and targets were red at the beginning of moving. ② The correct responses were analyzed with 3-factor repeated measures analysis of variance, multiple comparison analysis, and pairwise T-test.MAIN OUTCOME MEASURES: Response time and accuracy of pressing the keys.RESULTS: The data of 24 participants were involved in the final statistical analysis. ① The three-factor repeated measures ANOVA results showed that the main effect of the number change of distractors was significant [F(1,22)=6.040, P < 0.05]. The further ANOVA and pairwise comparison in different experiment conditions also showed no distractive effects when target and distractor had different shape but the same color [F(1,2,3)=9.965, P < 0.01]. The further pairwise comparison indicated that when the number of distractors was 2 and 6, the participants' response latencies had no significant effects, and they had significant effect when the number of distractors was 2 and 10, or 6 and 10 (RT10-RT2=46 ms, P < 0.05, two-tail test; RT10-RT6=28ms, P < 0.05, one-tail test). These results showed that the increase in the number of distractors had distractive effects. ② There had no significant effect whether target and distractor had the same color or not, when the number of distractors was 2 and 10. And there had significant effects whether the color of target and distractor was the same or not when the number of distractors was 6; the same shape of target and distractor produced distractive effects (Tsame colons=1.926; Tdifferent colons=2.044,P < 0.05, one-tail test). The main effect of the color was not significant. The further pairwise comparison showed the same result. That is,the color change of diatractors had no obvious distractive effect.CONCLUSION: ① There was distractive effect when the number of distractors increased while the shape and color of distractor and target were different. ② There was no distractive effect when the number of distractors increased while the shape of distractor and target was the same. ③ There was distractive effect when the number of distractors increased while the shape of distractor and target was different, and there was distractive effect when the color of distractor and target was the same.
10.The effect of ClC-3 antisense oligonucleotide on apoptosis induced by thapsigargin in PC12 cells
Haining ZHANG ; Yongyuan GUAN ; Qinying QIU ; Hua HE
Chinese Pharmacological Bulletin 1986;0(06):-
AIM To investigate the effect of ClC-3 antisense oligonucleotide on apoptosis induced by thapsigargin in PC12 cells. METHODS Western-blot was performed to detect the protein expression of ClC-3 in PC12 cells. MTT assay was used to measure the effect of ClC-3 antisense oligonucleotide on growth inhibition induced by thapsigargin. The effect of ClC-3 antisense oligonucleotide on apoptosis was studied with the fluorescent microscopy, DNA agarose gel electrophoresis, flow cytometry analysis. RESULTS Compared with control group, transient transfection of PC12 cells with antisense oligonucleotide specific to ClC-3 caused an inhibitory effect on expression of ClC-3 protein in a time-and concentration-dependent manner,whereas the thapsigargin-induced reductions of viability of PC12 cells and apoptosis were markedly enhanced (P