Objective To compare the objective cure rate and perioperative complications 0f ten-sion free vaginal tape(TVT)and laparoscopic Burch for the treatment of fernale stress urinarv inconti-nence. Methods Literature search was conducted for all randomized control trials(RCTs)between 1994 and 2006,using MEDLINE,EMBASE with the keyword"tension free vaginal tape","colpo-suspension","stress urinary incontinence",then a second search was performed with the following keywords:[(tension free vaginal tape),AND(colposuspension),OR(Burch)],AND stress urinary incontinence].Gray literature was search in The Cochrane central register of controlled trials、NRR (National Research Register)、CCT(clinical controlled trials),ISTP,ISI proceedings,OCLC First-search proceedings,(CACP),GreyNet(http://www.greynet.org/)、DARE(Database of Abstract:s of Reviews of Effects)、SIGLE(System for Information on Grey Literature in Europc),official website of ICS.Meta-analysis was performed with RevMan software 4.2. Results right studies were included comparing objective cure rate and perioperative complications of TVT and LB.Overall objective cure rates were 233/259 for TVT and 189/247 for Burch respectively.TVT shared higher objective cure (RR 1.19,95%CI 1.10-1.29,P<0.01)and lower perioperative complications(RR 0.48,95%CI 0.32-0.71,P<0.05). Conclusions The available evidence indicates that TVT is an effective treat-ment for stress urinary incontinence with higher objective cure rate and 10wer perioperative complica-tions compared with LB.

Objective To investigate the clinical effect of ilium grafting combined with Duhuojishengtang on the delay fracture healing and explore the effect on hemorheology. Methods Eighty patients with delayed fracture healing were randomly divided into two groups. Forty patients in control group were treated by ilium grafting and 40 patients in observation group were treated by ilium grafting combined with Duhuojishengtang. The clinical effect was observed after treatment and indexes of hemorheology were recorded after different treatment time. Results The cure rate of observation group was 62.5%, which was significantly higher than that of control group 35.0%, the effective rate of observation group was 92.5%, which was significantly higher than that of control group 72.5% (P<0.01) . There were no significant differences between two groups in indexes of hemorheology after ilium grafting (P>0.05) . After the first, second, third course, the indexes of hemorheology of observation group were better than those of control group, with statistically significant differences (P<0.05) . Conclusions Ilium grafting com-bined with duhuojishengtang can improve the indexes of hemorheology, improve the cure and effective rate and also has high security. It has high clinical value and worth of popularization and application.

To investigate the effects of ligustrazine injection on type I collagen, matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) expressions in human peritoneal mesothelial cells (HPMCs) cultured in high glucose conditions.

Objective To observe the changes of serum 25‐hydroxy vitamin D[25‐(OH)D] level of patients with rheumatoid ar‐thritis(RA) and study its clinical significance .Methods The method of chemiluminescence was adopted to detect peripheral blood serum 25‐(OH) D of 60 cases of RA patients(RA group) and 60 cases of healthy people(control group) .Results The serum 25‐(OH) D level of patients in RA group was(34 .37 ± 8 .87) nmol/L ,while that of the control group was(61 .33 ± 7 .74) nmol/L ;after comparison ,the differences were statistically significant (t= -6 .892 ,P< 0 .05);the serum 25‐(OH) D level of patients in RA group was in negative correlation with RA patient age ,body mass index(BMI) ,time of morning stiffness ,tender joint count(TJC) , swollen joint count(SJC) ,C‐reactive protein(CRP) ,erythrocyte sedimentation rate(ESR) ,visual analog scale(VAS) for disease o‐verall pain and health assessment questionnaire (HAQ) and disease activity score (DAS28)(r= -0 .201 ,-0 .255 ,-0 .362 ,-0 .296 ,-0 .273 ,-0 .198 ,-0 .323 ,-0 .356 ,-0 .379 ,-0 .418 ;P<0 .05 in all cases);but had no correlation with course of dis‐ease ,rheumatoid factor (RF) ,anti‐cyclic citrullinated peptide (CCP) antibody (anti‐CCP) and antibody concentration (P> 0 .05) . Conclusion The serum 25‐(OH) D level of RA patients is significantly low ,which might be associated with the RA disease activi‐ty .

In this paper, the importance of using advanced medical equipment to check treatment was ana-lyzed, and then pointed out that nowadays there were the following problems: the medical staff had excessive de-pendence on medical equipment; medical equipment inspection treatment of irrationality; medical equipment in-spection treatment with humanity was not enough; medical equipment management of dereliction of duty. Put for-ward to strengthen medical personnel professional moral education;to strengthen the medical students' ethical edu-cation;regular hospital manage concept;improve the cognitive level of medical staff of medical equipment.

Objective Delivery of oxygen in tissues is limited in the space where oxygen must diffuse between the vascular and the surrounding tissues. Normal capillaries are relatively straight and well spaced, in contrast, the tumor vascular networks usually display more irregularity and the vessel wall shows higher permeability and less elasticity. The purpose of this study was to investigate the effect of capillary elasticity and tortuosity on the oxygen distribution and make further investigation on the mechanism of the formation of hypoxic regions in tumor. Method One-dimensional capillary model was coupled with the oxygen diffusion model. Oxygen transport was investigated in a Krogh and tortuous tissue model. The capillarygeometrywas obtained bythe one-dimensional model and transferred to the tissue model. Finite element method was employed in the analysis. Result The capillary radii along the flow direction under pressures were obtained for different initial radii and the oxygen distribution in the Krogh cylinder tissue model and the model with a tortuous capillary were computed. Conclusions when the capillary radius is small, the effect of vessel elasticity may have not significant effect on the oxygen distribution. However, with the capillary radius increasing, the effect on the oxygen transport becomes obvious. Moreover, with the tortuosity of the capillary increasing, the oxygen distribution becomes more heterogeneous, which is in agreement with the result in available reference. This work will be helpful to the investigation of oxygen transport within tumor.

Objective To investigate the effects of Ligustrazine on TNF-α-induced TGF-β and CTGF expression in human peritoneal mesothelial cells (HPMCs). Methods HPMCs were isolated from human omenta by trypsin di-gestion. Then, the subcultured HPMCs were divided into control group, TNF-α-induced (1 μg/L) group and TNF-α-induced plus low-, medium-and high-dose Ligustrazine (10, 20 and 40 mg/L Ligustrazine respectively) groups. The viability of HPMCs was measured by MTT assay. RT-PCR was used to detect the expressions of TGF-β1 and CTGF mRNAs in HPMCs. TGF-β1 and CTGF in supernatants were measured by ELISA. Cell protein concentration was measured by trace bicinchoninic acid (BCA) method to validate the ELISA assay results. Results Ligustrazine significantly decreases TNF-α-induced TGF-β1 and CTGF expression in a dose-dependent manner at both protein and gene levels ( P < 0. 05 ). In addition, medium-and high-dose Ligustrazine injection significantly ameliorates the viability of HPMCs inhibited by TNF-α ( P < 0. 05 ). Conclusion Ligustrazine inhibits expressions of TGF-β and CTGF of HPMCs in an inflammatory conditions.

At present,there are many problems in the cultivation for medical students including lack of humanistic education,insufficient healthy personality shaping and innovation education.We made explorations in aspects of updating education concept,enhancing faculty construction,emphasizing basic course teaching and promoting students' abilities so as to cultivate the comprehensive quality of students majored in medical imaging (ultrasonic medicine).

0.05) in the results of Vd of mannitol and glycerol for both rabbits and human studies

Tumor angiogenesis, resulting from the imbalance of angiogenic cytokines and angiogenesis inhibitors, is crucial for tumor growth and metastasis. As a new field of cancer therapy, tumor anti-angiogenesis therapy with regard to abrogation of tumor vasculature has become an important anti-tumor strategy. Gene therapies have the potential to provide antiangiogenic mediators specifically targeted to organs containing tumors and make a great improvement in this therapy. This article reviews the current understanding of tumor angiogenesis, with a focus on gene therapy in this field.