Anthracyclines ; pharmacology ; therapeutic use ; Antineoplastic Combined Chemotherapy Protocols ; therapeutic use ; Breast Neoplasms ; drug therapy ; metabolism ; Cisplatin ; administration & dosage ; Deoxycytidine ; administration & dosage ; analogs & derivatives ; Drug Resistance, Neoplasm ; Female ; Humans ; Taxoids ; administration & dosage ; Vinblastine ; administration & dosage ; analogs & derivatives

Integrins are a family of cell adhesion receptors that mediate cell-cell and cell-extracellular matrix adhesion, and interact with cytokines through a bidirectional signal transduction,thus regulating the biological behavior of pancreatic cancer cells,such as proliferation,apoptosis,invasion,and migration etc. Molecular and animal studies indicated that integrins targeted methods might benefit the early diagnosis and drug therapy of pancreatic cancer,which offered a new approach for the study of diagnosis and treatment of pancreatic cancer.

Objective To investigate pathogens of hepatitis B virus (HBV) ,hepatitis C virus(HCV) and treponema palladium (TP) current infection situation and trend among voluntary blood donors in Pingdingshan city .Methods The testing results of HB-sAg ,anti-HCV and anti-TP among voluntary blood donors were investigated and analyzed .Results Six-year total positive rates of HBsAg ,anti-HCV and anti-TP were 1 .24% ,0 .55% and 0 .48% ,respectively .Positive rates of HBsAg ,anti-HCV and anti-TP were going downward year after year ,in recent three years especially .Conclusion The initial effects of establishing a safe and fixed voluntary blood donor group have been shown .

Objective To observe the effect of oxymatrine on the Absorption of carbohydrate and fat and the activity of peroxisome proliferator activated receptor ? and ?.Methods 64 masculine SD rats were randomly divided into three groups,20 sugar tolerance test,20 triacylglycero Absorption test and 24 oxymatrine effecting on triacylglycero and cholesterin test,and observed the effect of oxymatrine on glycosidase activity,blood sugar and activity of peroxisome proliferator activated receptor ? and ?.Results ① The depressant effect of oxymatrine on the activity of glycosidase was strengthened by the increased dosage.② Oxymatrine could suppress the upgraded level of blood sugar after took amylon and cane-sugar,and inhibit the upgraded level of triacylglycerol after feed by olive oil and hypso-cholesterol,but did not suppress the upgraded level of blood sugar after took glucose and hardly influence the level of high density lipoprotein cholesterol and low density lipoprotein cholesterol.③ Oxymatrine could obviously activate the activity of peroxisome proliferator activated receptor ? and ?,the activity of peroxisome proliferator activated receptor ? and ? increased gradually by the augment of the oxymatrine,and expressed evident dose-response relation.Conclusions Oxymatrine could not only directly inhibit the Absorption of triacylglycerol and depress the elevated level of postprandial triacylglycerol,but also activate peroxisome proliferator activated receptor ?,moreover possess dose-response relation.

ObjectiveTo investigate the nursing scheme to prevent infection,thromboembolism,accidental shedding during application of permanent deep venous catheter in hemodialysis. Methods28 patients undergoing maintenance hemodialysis from January 2007 to February 2009 were randomly divided into the observation group and the control group with 14 patients in each group.The control group took conventional care only,the observation group was given pertinent nursing intervention.After treatment the number of patients with infection and thromboembolism were compared in both groups. ResultsAll patients were successfully placed catheters.Number of patients with infection,thromboembolism and accidental shedding in the observation group were less than those in the control group.But there was no significant difference in average indwelling time of catheters between two groups. ConclusionsApplication of permanent deep venous catheter in hemodialysis shows good effect,it can decrease the incidence of complication and should be widely applied.

This study was designed to evaluate the effect of estrogen to the growth of leiomyoma and the mechanism of testosterone propionate action on leiomy-oma.The levels of estrogen receptor in uterine tissud and those of estradiol and progesterone in uterine tissue and plasma were determined in 47 women with leiomyoma.The levels of estrogen receptor and estradiol in leiomyomatous tissues were 37.6?4.0 fmol/mg protein and 401.7?92.6 pg/g tissue,respectively.Both of them were higher than the corresponding levels in normal uterine tissues (P

Objective] To probe into a case of bilingual classroom teaching model in a TCM university, expect to find that if the current bilingual teaching could achieve the goal of raising ability both in disciplinary knowledge and language competence advocated by content-based instruction teaching idea, explore the possible problems and propose some corresponding solutions. [Methods] Empirical research method was used to execute quantification statistics on classroom teaching activity and the discourse between teacher and students, combining with qualitative data from questionnaires and interviews. By the methods above, this paper expected to embody the present situation and problems of the bilingual teaching in a TCM university. [Results] For classroom teaching both in disciplinary knowledge and language forms, there was a phenomenon that input and output forms were single, so that the function of other effective classroom activities was ignored. It was still a teacher-centered classroom with teacher as the main body of classroom. Students' insufficient competence and teachers' limited level were still a main problem to be solved. Compared with time of disciplinary knowledge, focus on language was less and the output time of language was compressed. [Conclusion] It's necessary to richen the classroom teaching mode. Cognition of both teacher and students on bilingual teaching shall change, giving consideration to disciplinary knowledge and language competence, overcoming language weakness and facilitating the two-sided promotion.

Objective To summarize our experience in the diagnosis and treatment of right hemicolon carcinoma combined with acute appendicitis.Methods A respective analysis of clinical data of 51 cases of right colon cancer complicated with acute appendicitis and confirmed by surgical operation and pathology was made.Results In 2400 cases of right colon cancer,51 cases(2.1%)complicated with appendicitis.There were medical complications in 39 cases(76.5%).The diagnosis before operation was made in 13 cases(25.5%),and diagnosis of colon cancer was missed in 38 cases(74.5%).Colon adenocarcinoma was found in 40 cases,mucous adenocarcinoma 7 cases(13.7%),undifferentiated carcinoma 4 cases(7.8%);and Dukes B,C,D stages were in 2 cases(3.9%),29 cases(56.9%)and 20 cases(39.2%)respectively.The simple appendicitis,suppurative appendicitis,gangrenous appendicitis and phlegnomous appendicitis was found in 28 cases(54.9%),11 cases(21.6%),8 cases(15.7%)and 4 cases(7.8%)respectively.3-5-year survival was 95.2%,40.0%,respectively.Conclusions Occurrence rate of right colon cancer combined with appendicitis is low,but misdiagnosis rate is high,and 5-year survival rate is low.Middle and old age patients with appendicitis and accompanied with emaciation,anemia,digestive symptoms and right lower abdominal mass should have appropriate examination to avoid missing the diagnosis of right colon cancer.

Competing endogenous RNAs (ceRNAs) transcripts can communicate with microRNAs (miRNAs) through competitively binding the common miRNA response elements (MREs),which remove or decrease the repression of target genes of miRNAs.The present studies indicate that a large amount of genes,serving as ceRNAs,can promote or inhibit the occurrence of liver cancer by competing the binding site of same genes that can promote or suppress tumorigenesis.

OBJECTIVE:To observe the therapeutic effect of compound glycyrrhizin injection on herpes zoster METHOD_S:50 cases of herpes zoster received compound glycyrrhizin injection 60ml q d intravenous drip for 5 days RESULTS:Curative rate was 22% and improving rate 64% with a total effective rate of 86% CONCLUSION:Compound glycyrrhizin has corticosteroid-like action,which could regulate immunologic function and inhibit virus