1.Recent Advances in the Management of Autosomal Dominant Polycystic Kidney Disease.
Korean Journal of Medicine 2015;89(2):169-178
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease. It is characterized by the dysregulated growth of kidney cysts, resulting in end-stage kidney failure. By identifying the genes involved in ADPKD and detailing the molecular pathology of the disease, putative therapeutic agents have been developed. However, clinical trials of vasopressin receptor antagonists and somatostatin analogues have raised several concerns among researchers and clinicians. Questions regarding when and who to treat and what surrogate marker to use for describing endpoints have been raised. This review focuses on the current methods for managing ADPKD and describes recent findings from clinical trials. The main difficulties associated with implementing therapeutic agents in patients with ADPKD and considerations for clinical settings will also be discussed.
Biomarkers
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Humans
;
Hypertension
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Kidney
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Kidney Diseases
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Pathology, Molecular
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Polycystic Kidney Diseases
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Polycystic Kidney, Autosomal Dominant*
;
Receptors, Vasopressin
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Renal Insufficiency
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Renal Insufficiency, Chronic
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Somatostatin
3.Effectiveness of inactivated hantavirus vaccine on the disease severity of hemorrhagic fever with renal syndrome.
Yongjin YI ; Hayne PARK ; Jaehun JUNG
Kidney Research and Clinical Practice 2018;37(4):366-372
BACKGROUND: An inactivated Hantaan virus vaccine (iHV) has been broadly used as a preventive strategy for hemorrhagic fever with renal syndrome (HFRS) by the South Korean Army. After the vaccination program was initiated, the overall incidence of HFRS cases was reduced in the military population. While there are about 400 HFRS cases annually, few studies have demonstrated the efficacy of the iHV in field settings. Therefore, this study aimed to evaluate the iHV efficacy on HFRS severity. METHODS: From 2009 to 2017, HFRS cases were collected in South Korean Army hospitals along with patients’ vaccination history. HFRS patients were classified retrospectively into two groups according to vaccination records: no history of iHV vaccination and valid vaccination. Vaccine efficacy on the severity of acute kidney injury (AKI) stage and dialysis events were investigated. RESULTS: The effects of the iHV on renal injury severity in between 18 valid vaccinated and 110 non-vaccinated patients were respectively evaluated. In the valid vaccination group, six of the 18 HFRS patients (33.3%) had stage 3 AKI, compared to 60 of the 110 (54.5%) patients in the non-vaccination group. The iHV efficacy against disease progression (VEp) was 58.1% (95% confidence interval, 31.3% to 88.0%). CONCLUSION: The iHV efficacy against the progression of HFRS failed to demonstrate statistically significant protection. However, different severity profiles were observed between the iHV and non-vaccination groups. Additional studies with larger populations are needed to demonstrate the effectiveness of the iHV in patients with HFRS.
Acute Kidney Injury
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Dialysis
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Disease Progression
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Hantaan virus
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Hantavirus*
;
Hemorrhagic Fever with Renal Syndrome*
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Hospitals, Military
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Humans
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Incidence
;
Military Personnel
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Preventive Medicine
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Retrospective Studies
;
Vaccination
4.Clinical and genetic characteristics of Korean autosomal dominant polycystic kidney disease patients
Yun Kyu OH ; Hayne Cho PARK ; Hyunjin RYU ; Yong-Chul KIM ; Kook-Hwan OH
The Korean Journal of Internal Medicine 2021;36(4):767-779
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease. It is characterized by cyst growth in the kidneys, resulting in kidney enlargement and end-stage kidney disease. The polycystic kidney disease 1 (PKD1) and PKD2 have been identified as genes related to ADPKD and their significance in the molecular pathology of the disease has been studied. A disease-modifying drug has been approved; therefore, it has become important to identify patients at a high risk of kidney disease progression. Genetic tests, image analysis methods, and clinical factors for kidney disease progression prediction have been established. This review describes genetic and clinical characteristics, and discusses ongoing studies in Korean ADPKD patients.
5.Clinical and genetic characteristics of Korean autosomal dominant polycystic kidney disease patients
Yun Kyu OH ; Hayne Cho PARK ; Hyunjin RYU ; Yong-Chul KIM ; Kook-Hwan OH
The Korean Journal of Internal Medicine 2021;36(4):767-779
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease. It is characterized by cyst growth in the kidneys, resulting in kidney enlargement and end-stage kidney disease. The polycystic kidney disease 1 (PKD1) and PKD2 have been identified as genes related to ADPKD and their significance in the molecular pathology of the disease has been studied. A disease-modifying drug has been approved; therefore, it has become important to identify patients at a high risk of kidney disease progression. Genetic tests, image analysis methods, and clinical factors for kidney disease progression prediction have been established. This review describes genetic and clinical characteristics, and discusses ongoing studies in Korean ADPKD patients.
6.A Case of Encapsulating Peritoneal Sclerosis Significantly Improved after Enterolysis.
Hyun Bae YOON ; Hayne Cho PARK ; Hajeong LEE ; Seung Suk HAN ; Kyu Joo PARK ; Ju Young MOON ; Curie AHN ; Kook Hwan OH
Korean Journal of Nephrology 2008;27(3):407-411
Encapsulating peritoneal sclerosis (EPS) is a rare but fatal complication of continuous ambulatory peritoneal dialysis (CAPD). There are some reports on the effect of immunosuppressant therapy including steroid, but the results have not always been promising. Recently, owing to the advance of surgical techniques, there are some reports of the EPS cases significantly improved after successful surgery. A 30-year old man developed EPS after 9 years of peritoneal dialysis, and switched to hemodialysis. In spite of repetitive conservative management and immunosuppressant therapy, there was no improvement. His body weight decreased from 50 kg to 40 kg (BMI 14.2 kg/m2) due to severe malnutrition, so we decided to perform surgery. Total intestinal enterolysis was done successfully without concomitant enterectomy, and his general condition improved dramatically. Four months after surgery, the serum albumin concentration increased from 3.1 g/dL to 4.3 g/dL, cholesterol from 92 mg/dL to 208 mg/dL, and hemoglobin from 9.2 g/dL to 12.5 g/dL. His body weight increased to 61 kg (BMI 21.6 kg/m2), and there was not any fluid collection or bowel obstruction seen on the abdominal CT scan. We experienced a case of EPS which was significantly improved after enterolysis. We report this case with review of the literature.
Body Weight
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Cholesterol
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Hemoglobins
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Malnutrition
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Peritoneal Dialysis
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Peritoneal Dialysis, Continuous Ambulatory
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Peritoneal Fibrosis
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Peritonitis
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Renal Dialysis
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Serum Albumin
7.Xp11.2 translocation renal cell carcinoma in the autosomal dominant polycystic kidney disease patient with preserved renal function.
Hyuk HUH ; Hyung Ah JO ; YongJin YI ; Seung Hyup KIM ; Kyung Chul MOON ; Curie AHN ; Hayne Cho PARK
The Korean Journal of Internal Medicine 2017;32(6):1108-1111
No abstract available.
Carcinoma, Renal Cell*
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Humans
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Polycystic Kidney, Autosomal Dominant*
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Translocation, Genetic
8.Lower Residual Renal Function is a Risk Factor for Depression and Impaired Health-Related Quality of Life in Korean Peritoneal Dialysis Patients.
Hayne Cho PARK ; Hajeong LEE ; Jung Pyo LEE ; Dong Ki KIM ; Kook Hwan OH ; Kwon Wook JOO ; Chun Soo LIM ; Yon Su KIM ; Curie AHN ; Yun Kyu OH
Journal of Korean Medical Science 2012;27(1):64-71
We retrospectively evaluated demographic and biochemical parameters associated with depression and health-related quality of life (HRQOL) in maintenance peritoneal dialysis (PD) patients. This study included 105 patients maintaining PD at Seoul National University Hospital. Data were collected from electronic medical record. Korean Beck's Depression Inventory and Korean version of Kidney Disease Quality of Life short form, version 1.3 were used to evaluate depression and HRQOL, respectively. Moderate to severe depression was found in 24.8% of patients. Patients with lower normalized protein equivalent of nitrogen appearance (nPNA) (< 1.2 g/kg/day), lower weekly renal Kt/V(urea) (< 0.2), and lower serum albumin level (< or = 4.0 g/dL) were associated with depression (P < 0.05). Among them, lower weekly renal Kt/V(urea) was the only independent risk factor associated with depression (OR = 3.1, P = 0.007). Depressed patients showed significantly lower scores in every dimension of HRQOL (P < 0.001). Lower weekly renal Kt/V(urea) (beta = 0.24, P = 0.005) and lower nPNA (beta = 0.15, P = 0.03) were the independent risk factors associated with lower kidney dialysis component summary, whereas lower plasma hemoglobin level was the consistent risk factor for lower physical component summary (beta = 0.22, P = 0.03) and mental component summary (beta = 0.22, P = 0.01). Depression is a prevalent psychological problem in PD population. Residual renal function is the most important factor associated with depression and impaired HRQOL in PD patients.
Adult
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Aged
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Demography
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Depression/*etiology
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Female
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Health Status
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Hemoglobins/analysis
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Humans
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Kidney Diseases/*complications/physiopathology/*psychology
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Male
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Middle Aged
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Peritoneal Dialysis
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*Quality of Life
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Republic of Korea
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Retrospective Studies
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Risk Factors
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Serum Albumin/analysis
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Software
9.Treatment Outcomes and Prognostic Factors for Peritoneal Dialysis Patients Based on Single Center Experience over 18 years.
Hyun Bae YOON ; Hayne Cho PARK ; Hajeong LEE ; Seung Suk HAN ; Sejoong KIM ; Kwon Wook JOO ; Yon Su KIM ; Curie AHN ; Jin Suk HAN ; Suhnggwon KIM ; Kook Hwan OH
Korean Journal of Nephrology 2009;28(1):19-31
PURPOSE:We investigated the survival rate, factors associated with survival, and peritonitis incidence in PD patients who commenced PD at our center since 1990. METHODS:We investigated 670 patients who started PD between January 1990 and June 2007. Data for sex, age, etiology of ESRD, comorbidities, follow-up duration, cause of death, and peritonitis were analyzed. Kaplan-Meier method was used to determine patient survival and technique survival rate. RESULTS:The most common cause of death was cardiovascular disease, while peritonitis was the main reason for technique failure. The overall incidence of peritonitis between 1995 and 2007 was 0.270 episodes per patient-year, and there was a significant drop of peritonitis rate from 1995-1999 (0.365) to 2000-2007 (0.230). Patient survival after 5 and 10 years was 71.7% and 48.2% respectively. Technique survival after 5 and 10 years was 72.8% and 43.8%. Older age (age 40-59: HR 2.427, p= 0.016; age> or =60: HR 7.397, p<0.001), diabetes (HR 1.973, p=0.001), and cardiovascular disease (HR 2.040, p<0.001) were the independent risk factors of mortality, while older age (age> or =60: HR 1.791, p=0.025) and higher peritonitis rate (HR 2.361, p<0.001) were the independent risk factors of technique failure. CONCLUSION:The patient survival, technique survival and peritonitis incidence of PD patients in our center showed outcomes comparable to other centers worldwide. Older age, diabetes, and cardiovascular disease were associated with lower patient survival, while older age and higher peritonitis rate were associated with higher technique failure.
Cardiovascular Diseases
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Cause of Death
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Comorbidity
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Follow-Up Studies
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Humans
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Incidence
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Kidney Failure, Chronic
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Peritoneal Dialysis
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Peritonitis
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Risk Factors
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Survival Rate
10.Treatment Outcomes and Prognostic Factors for Peritoneal Dialysis Patients Based on Single Center Experience over 18 years.
Hyun Bae YOON ; Hayne Cho PARK ; Hajeong LEE ; Seung Suk HAN ; Sejoong KIM ; Kwon Wook JOO ; Yon Su KIM ; Curie AHN ; Jin Suk HAN ; Suhnggwon KIM ; Kook Hwan OH
Korean Journal of Nephrology 2009;28(1):19-31
PURPOSE:We investigated the survival rate, factors associated with survival, and peritonitis incidence in PD patients who commenced PD at our center since 1990. METHODS:We investigated 670 patients who started PD between January 1990 and June 2007. Data for sex, age, etiology of ESRD, comorbidities, follow-up duration, cause of death, and peritonitis were analyzed. Kaplan-Meier method was used to determine patient survival and technique survival rate. RESULTS:The most common cause of death was cardiovascular disease, while peritonitis was the main reason for technique failure. The overall incidence of peritonitis between 1995 and 2007 was 0.270 episodes per patient-year, and there was a significant drop of peritonitis rate from 1995-1999 (0.365) to 2000-2007 (0.230). Patient survival after 5 and 10 years was 71.7% and 48.2% respectively. Technique survival after 5 and 10 years was 72.8% and 43.8%. Older age (age 40-59: HR 2.427, p= 0.016; age> or =60: HR 7.397, p<0.001), diabetes (HR 1.973, p=0.001), and cardiovascular disease (HR 2.040, p<0.001) were the independent risk factors of mortality, while older age (age> or =60: HR 1.791, p=0.025) and higher peritonitis rate (HR 2.361, p<0.001) were the independent risk factors of technique failure. CONCLUSION:The patient survival, technique survival and peritonitis incidence of PD patients in our center showed outcomes comparable to other centers worldwide. Older age, diabetes, and cardiovascular disease were associated with lower patient survival, while older age and higher peritonitis rate were associated with higher technique failure.
Cardiovascular Diseases
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Cause of Death
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Comorbidity
;
Follow-Up Studies
;
Humans
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Incidence
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Kidney Failure, Chronic
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Peritoneal Dialysis
;
Peritonitis
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Risk Factors
;
Survival Rate