2.Significance of rescue hybrid endoscopic submucosal dissection in difficult colorectal cases
Hayato YAMAGUCHI ; Masakatsu FUKUZAWA ; Takashi KAWAI ; Takahiro MURAMATSU ; Taisuke MATSUMOTO ; Kumiko UCHIDA ; Yohei KOYAMA ; Akira MADARAME ; Takashi MORISE ; Shin KONO ; Sakiko NAITO ; Naoyoshi NAGATA ; Mitsushige SUGIMOTO ; Takao ITOI
Clinical Endoscopy 2023;56(6):778-789
Background/Aims:
Hybrid endoscopic submucosal dissection (ESD), in which an incision is made around a lesion and snaring is performed after submucosal dissection, has some advantages in colorectal surgery, including shorter procedure time and preventing perforation. However, its value for rescue resection in difficult colorectal ESD cases remains unclear. This study evaluated the utility of rescue hybrid ESD (RH-ESD).
Methods:
We divided 364 colorectal ESD procedures into the conventional ESD group (C-ESD, n=260), scheduled hybrid ESD group (SH-ESD, n=69), and RH-ESD group (n=35) and compared their clinical outcomes.
Results:
Resection time was significantly shorter in the following order: RH-ESD (149 [90–197] minutes) >C-ESD (90 [60–140] minutes) >SH-ESD (52 [29–80] minutes). The en bloc resection rate increased significantly in the following order: RH-ESD (48.6%), SH-ESD (78.3%), and C-ESD (97.7%). An analysis of factors related to piecemeal resection of RH-ESD revealed that the submucosal dissection rate was significantly lower in the piecemeal resection group (25% [20%–30%]) than in the en bloc resection group (40% [20%–60%]).
Conclusions
RH-ESD was ineffective in terms of curative resection because of the low en bloc resection rate, but was useful for avoiding surgery.
3.Effective Use of Coix-seed Reactive Derivatives (CRD) in Managing Photoaging of the Skin: A Case Report
Nobutaka SUZUKI ; Hayato SUGIMOTO ; Shintaro HASHIMOTO ; Hoko KYO ; Kazuo UEBABA
Japanese Journal of Complementary and Alternative Medicine 2019;16(1):53-56
Ultraviolet (UV)-induced wrinkle and pigmentation are very common in clinical practice. In this report, we presented the case of a 58-year-old man who developed wrinkle and pigmentation around right hand, face and neck for ten years. Coix-seed Reactive Derivatives (CRD) was administrated orally 2.1g twice a day for 6 months. These lesions were improved in the third month, and a dramatic response was obtained at the end of 6 months of treatment. Further research is needed to define the optimal dose and duration of CRD intake.
4.Successful Treatment of Severe Friction Melanosis with Coix-seed Reactive Derivatives (CRD): A Case Report
Nobutaka SUZUKI ; Hayato SUGIMOTO ; Shintaro HASHIMOTO ; Hoko KYO ; Kazuo UEBABA
Japanese Journal of Complementary and Alternative Medicine 2019;16(1):57-60
Friction melanosis is a cutaneous entity characterized by a brownish pigmentation distributed on the skin over bony regions of various sites including a trunk or the limbs, after the use, for many years, of a nylon towel or scrub brush to clean the skin. Moreover, repeated trauma due to friction of clothes on the skin over bony prominences are another factors characterizing its pathogenesis. In this report, we presented the case of a 58-year-old man who developed severe friction melanosis around both knees and lower extremities for about 20 years. Coix-seed Reactive Derivatives (CRD) was administrated orally 2.1g twice a day for 6 months. The lesions of pigmentation diminished markedly within 3 months. Further research is needed to define the optimal dose and duration of CRD intake against friction melanosis.