1.Unresolving furunculosis in a diabetic patient: cutaneous Mycobacterium abscessus infection.
Haur Yueh LEE ; Yong Mong BEE ; T THIRUMOORTHY
Annals of the Academy of Medicine, Singapore 2009;38(2):166-167
Abdominal Wall
;
Anti-Bacterial Agents
;
therapeutic use
;
Biopsy
;
Clarithromycin
;
therapeutic use
;
Diabetes Mellitus, Type 2
;
complications
;
Diagnosis, Differential
;
Female
;
Follow-Up Studies
;
Furunculosis
;
complications
;
diagnosis
;
drug therapy
;
Humans
;
Middle Aged
;
Mycobacterium
;
isolation & purification
;
Mycobacterium Infections, Nontuberculous
;
complications
;
diagnosis
;
drug therapy
;
Skin Diseases, Bacterial
;
diagnosis
;
drug therapy
3.Relapsing Course of Sulfasalazine-Induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Complicated by Alopecia Universalis and Vitiligo.
Bertrand Sy LIAN ; Inny BUSMANIS ; Haur Yueh LEE
Annals of the Academy of Medicine, Singapore 2018;47(11):492-493
Alopecia
;
chemically induced
;
diagnosis
;
Antirheumatic Agents
;
administration & dosage
;
adverse effects
;
Arthritis, Rheumatoid
;
drug therapy
;
Biopsy
;
methods
;
Cyclosporine
;
administration & dosage
;
Dermatologic Agents
;
administration & dosage
;
Drug Hypersensitivity Syndrome
;
diagnosis
;
etiology
;
physiopathology
;
therapy
;
Humans
;
Male
;
Middle Aged
;
Prednisolone
;
administration & dosage
;
Skin
;
pathology
;
Sulfasalazine
;
administration & dosage
;
adverse effects
;
Symptom Flare Up
;
Treatment Outcome
;
Vitiligo
;
chemically induced
;
diagnosis
5.Melanoma: differences between Asian and Caucasian patients.
Haur Yueh LEE ; Wen Yee CHAY ; Mark By TANG ; Martin Tw CHIO ; Suat Hoon TAN
Annals of the Academy of Medicine, Singapore 2012;41(1):17-20
INTRODUCTIONCutaneous melanoma is rare in Asia and the clinical presentation and outcome of melanoma is not well described in Southeast Asia. In addition, it is unclear if ethnic variations exist between the various racial groups. The objective of our study is to present the clinical characteristics of melanoma in Singapore and to highlight ethnical differences between Asians and Caucasians living in Singapore.
MATERIALS AND METHODSData were retrospectively collected from 48 patients with histological confirmation of melanoma who were seen in both the National Skin Centre and National Cancer Centre of Singapore.
RESULTSAcral lentiginous melanoma (ALM) was the most common subtype of melanoma in Singapore (50%). A higher proportion of non-ALM subtypes of melanoma compared to ALM were diagnosed at stage 1 (48% vs. 25%). The delay in diagnosis of ALM was 27 months compared to 12 months in other subtypes. Compared to Caucasians, there was a trend towards Asian patients being older, having a higher proportion of ALM and a longer delay to diagnosis.
CONCLUSIONGeographical and ethnic variations in the clinical presentation of melanoma exist. Specially adapted programmes are necessary to increase awareness of the different clinical presentation of melanoma in Asia and to encourage examination of the palms and soles in order to reduce the delay in diagnosis.
Adult ; Aged ; Aged, 80 and over ; Asian Continental Ancestry Group ; European Continental Ancestry Group ; Female ; Humans ; Male ; Melanoma ; diagnosis ; epidemiology ; ethnology ; pathology ; Middle Aged ; Retrospective Studies ; Singapore ; epidemiology ; Skin Neoplasms ; diagnosis ; epidemiology ; ethnology ; pathology
8.Early experience of inpatient teledermatology in Singapore during COVID-19.
Wen Hao TAN ; Chee Hoou LOH ; Zi Teng CHAI ; Dawn A Q OH ; Choon Chiat OH ; Yi Wei YEO ; Karen J L CHOO ; Haur Yueh LEE
Annals of the Academy of Medicine, Singapore 2021;50(6):487-489
COVID-19
;
Dermatology
;
Humans
;
Inpatients
;
SARS-CoV-2
;
Singapore
9.Improving drug allergy label accuracy by supervised safety- and protocol-driven evaluation.
Chiara Jiamin CHONG ; Karen Jui Lin CHOO ; Kheng Yong ONG ; Vivian TAN ; Janet Beng Neo KHOO ; Kavitha Garuna MURTHEE ; Ibrahim Muhammad HANIF ; Chaw Su NAING ; Haur Yueh LEE
Annals of the Academy of Medicine, Singapore 2022;51(11):677-685
INTRODUCTION:
Drug allergies are often self-reported but of unknown accuracy. We carried out a prospective study to examine the utility and safety of formal allergology evaluation, and to identify factors associated with accurate drug allergy labels.
METHOD:
All patients who underwent drug allergy evaluation in our clinic during the study period were recruited. Baseline demographics, characteristics of index hypersensitivity reaction and outcomes of evaluation were recorded.
RESULTS:
A total of 331 patients from March 2019 to June 2021 completed drug allergy evaluation to index drugs of concern. There were 123 (37%) male patients, and the mean age was 49 years (standard deviation 17). There were 170 beta-lactam antibiotics, 53 peri-operative drugs, 43 others, 38 non steroidal anti-inflammatory drugs, and 27 non-beta-lactam antibiotic evaluations. Index reaction occurred within 5 years in 165 (50%) patients, with latency of less than 4 hours in 125 (38%) patients. The most common index reactions were rash, angioedema and urticaria. There were 57 (17%) evaluations stratified as low risk, 222 (67%) moderate risk, and 52 (16%) high risk based on multidisciplinary consensus. Allergy label was found to be false (negative drug evaluation) in 248 (75%) patients, while 16/237 (7%) skin tests, 44/331 (13%) in-clinic graded challenge, and 23/134 (17%) home prolonged challenges were positive (true drug allergy). The most common evaluation reactions were rash and urticaria. No cases of anaphylaxis were elicited.
CONCLUSION
Seventy-five percent of drug allergy labels are inaccurate. Risk-stratified, protocolised allergy evaluation is safe. Prolonged drug challenge increases the sensitivity of drug allergy evaluation and should therefore be performed when indicated.
Humans
;
Male
;
Middle Aged
;
Female
;
Prospective Studies
;
Drug Hypersensitivity/epidemiology*
;
Exanthema
;
Urticaria
;
Monobactams
10.Intravascular large B-cell lymphoma presenting as panniculitis clinically: a case report.
Yee Wei PHOON ; Xuling LIN ; T THIRUMOORTHY ; Soo Yong TAN ; Hwei Yee LEE ; Soon Thye LIM ; Haur Yueh LEE
Singapore medical journal 2018;59(3):163-164
Biopsy
;
CD79 Antigens
;
metabolism
;
Central Nervous System
;
Diagnosis, Differential
;
Female
;
Humans
;
Immunohistochemistry
;
Inflammation
;
Ki-67 Antigen
;
metabolism
;
Lymphoma, Large B-Cell, Diffuse
;
diagnosis
;
Magnetic Resonance Imaging
;
Middle Aged
;
Panniculitis
;
diagnostic imaging
;
Prognosis