1.Neurological Characteristics of Allgrove Syndrome: A Case Series
Dhoha Ben SALAH ; Mouna ELLEUCH ; Oumeyma TRIMECHE ; Asma ZARGNI ; Fakhri KALLABI ; Salma SAKKA ; Fatma MNIF ; Nabila REKIK ; Nadia CHARFI ; Hassen KAMOUN ; Mouna Mnif FEKI ; Faten Hadj KACEM ; Mohamed ABID
Annals of Child Neurology 2024;32(2):130-134
Purpose:
Allgrove syndrome, also known as “triple A” syndrome, is characterized by adrenal insufficiency, achalasia, and alacrimia. When neurological signs are also present, the condition is referred to as “4 A” syndrome.
Methods:
We conducted a retrospective analysis of three patients with 4 A syndrome confirmed genetically. A complete neurological exam was carried out by an experimented neurologist.
Results:
Herein, we describe the neurological characteristics often associated with this condition, through the clinical and electrophysiological analysis of three patients. All patients exhibited a mutation in AAAS, the gene coding for ALADIN. While these individuals presented with the classic features of triple-A syndrome, neurological symptoms were not prominent.
Conclusion
The neurological manifestations of Allgrove syndrome have historically been overlooked and inadequately explored. Due to the condition’s rarity and substantial phenotypic heterogeneity, only recently have a variety of symptoms been recognized and described.
Result Analysis
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