125 patients with Basedow disease associated with Hashimoto disease were investigated (in comparative with 88 patients subfering from single Basedow disease) at Military Hospital No 103 from January 1996 to June 2002. Results showed no difference between two groups in terms of the age of disease developing thyroid tumor of 3nd grade was occurred usually in both 2 groups, while the tumor of 4th grade occurred usually in the group of Basedow associated with Hashimoto disease. The tumor of Basedow associated with Hashimoto disease used to get high intensity, harderning in the grey and rose color while in the patient with simple Basedow disease, the tumor had low intensity, soft consistency and purple color.
Diagnosis ; Graves Disease ; Hashimoto Disease

Cytokines ; Hashimoto Disease ; diagnosis ; prevention & control ; Humans

Riedel thyroiditis is a benign disease, which is often self-limited. Examinations, such as CT and histologic diagnosis can distinguish it from malignant neoplasms and hashimoto's thyroiditis. Riedel thyroiditis is an uncommon form of chronic thyroiditis in which the thyroid gland is replaced by fibrous tissue. It can be cured by surgery and medicine.
Chronic Disease ; Diagnosis, Differential ; Hashimoto Disease ; diagnosis ; Humans ; Thyroiditis ; diagnosis

Hashimoto encephalopathy shares common clinical features with Creutzfeldt-Jakob disease and must be regarded as a differential diagnosis because of its good prognosis. We report a case of Hashimoto encephalopathy, which had not been recognized before the diagnosis of Creutzfeldt-Jakob disease. The electroclinical findings were compatible with probable Creutzfeldt-Jakob disease and coexistence of Hashimoto thyroiditis was supported by high titers of anti-thyroid microsomal antibody and cytopathologic findings. Hashimoto encephalopathy was not improved, which was most likely due to the coexistence of Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome* ; Diagnosis ; Diagnosis, Differential ; Hashimoto Disease ; Prognosis

No abstract available.
Female ; Hashimoto Disease/*complications/diagnosis ; Humans ; Polymyositis/*complications/diagnosis ; Young Adult

Encephalitis ; diagnosis ; epidemiology ; etiology ; therapy ; Hashimoto Disease ; diagnosis ; epidemiology ; etiology ; therapy ; Humans

A 52-year-old female patient with Hashimoto encephalopathy was admitted to hospital for clinical treatment, and the findings on MR spectroscopy (MRS) and MR imaging (MRI) in the brain were reported. MRS revealed the decreases in N-acetylaspartate (NAA/Cr=1.19) and myo-inositol peaks, and the elevations in lipid, lactate, glutamate/glutamine multiplet and choline (Cho/Cr=1.21) peaks which supported a cerebral inflammatory change, in addition to multifocal hyperintensities on T2WI and fluid-attenuated inversion recovery (FLAIR) images, slight hyperintensities on diffusion weighted imaging (DWI), hypointensities on T1WI. The atrophy of the brain was revealed on follow-up MRI two years later.
Brain Diseases ; diagnosis ; Encephalitis ; Female ; Hashimoto Disease ; diagnosis ; Humans ; Magnetic Resonance Spectroscopy ; Middle Aged

Objective: To evaluate the value of the 2020 diagnostic criteria (Cellucci criteria) for pediatric autoimmune encephalitis (AE) in children with suspected AE in a single center. Methods: The clinical data of 121 children hospitalized at the First Affiliated Hospital of Zhengzhou University from October 2019 to October 2021, with a diagnosis of suspected AE, were retrospectively collected and analyzed. The children were divided into definite antibody-positive AE (dAPAE), probable antibody-negative AE (prANAE), possible AE (pAE) and non-AE groups according to the Chinese expert consensus and the Graus criteria. A new diagnosis was made according to the Cellucci criteria which was compared with the clinical diagnosis to evaluate the diagnostic value of the Cellucci criteria. The Mann-Whitney U test, Kruskal-Wallis test, and χ² test were used to compare the differences among groups. The sensitivity and specificity were used to evaluate efficacy of the Cellucci criteria. Results: Among the 121 children, 72 were males and 49 were females, with an age of 10.3 (6.5, 14.0) years at disease onset. There were 99 cases diagnosed as AE according the clinical diagnosis (58 males and 41 females), of which 43 cases were diagnosed as dAPAE, 14 cases as prANAE and 42 cases as pAE, and the other 22 cases were not AE (14 males and 8 females). The top 2 initial symptoms in the 99 children with AE were seizures (53 cases, 53.5%) and abnormal mental behaviors (35 cases, 35.4%). And the most common symptoms during the course of the disease were abnormal mental behaviors (77 cases, 77.8%) and seizures (64 cases, 64.6%). There were statistically differences in the incidence of consciousness disorders, autonomic dysfunctions during the course of the disease and the length of hospitalization among the 4 groups (χ²=21.63, 13.74, H=22.60, all P<0.05). Ninety-six of the 121 children were tested for AE-related antibodies, of which 45 cases (46.9%) were antibody-positive. According to the Cellucci criteria, 42 cases were diagnosed as dAPAE, 34 cases as prANAE and 14 cases as pAE. Compared with the clinical diagnosis, the sensitivity of the Cellucci criteria for the diagnosis of the 3 types of AE were 93.02%, 92.86% and 87.88%, and the specificity were 96.23%, 74.39% and 86.36%, respectively. Conclusions: The Cellucci criteria has a high sensitivity and specificity for the diagnosis of pAE and dAPAE in the clinical management of children with suspected AE, while a high sensitivity but low specificity for the diagnosis of prANAE. Therefore, it is recommended to apply the Cellucci criteria selectively in clinical practice according to the actual situation, especially in the diagnosis of prANAE.
Child ; Encephalitis/diagnosis* ; Female ; Hashimoto Disease/diagnosis* ; Humans ; Male ; Retrospective Studies ; Seizures

Diagnosis, Differential ; Female ; Granuloma ; diagnosis ; etiology ; Hashimoto Disease ; diagnosis ; etiology ; Hepatitis ; diagnosis ; etiology ; Humans ; Middle Aged ; Sarcoidosis ; complications ; diagnosis

PURPOSE: To evaluate the diagnostic accuracy of routine calcitonin measurement in patients with nodular thyroid disease. METHODS: Consecutive patients with nodular thyroid disease (n = 640) were studied. Serum calcitonin levels were measured under basal conditions, and when basal values were between 10–100 pg/mL, testing was repeated after pentagastrin (PG) stimulation. Patients with previously diagnosed or familial medullary thyroid cancer (MTC) were excluded. Patients were operated on when basal or stimulated calcitonin >100 pg/mL or when other surgical indications were present. RESULTS: Four cases of MTC were identified. MTC was diagnosed in 75% of patients with basal calcitonin >100 pg/mL. One out of 11 patients with basal calcitonin between 10–100 pg/mL was diagnosed with MTC. PG stimulation resulted in elevation in 4 cases, where 1 case was diagnosed with MTC. Positive predictive value for basal calcitonin levels in the preoperative diagnosis of MTC was 5% for values between 10–100 pg/mL and 100% for values >100 pg/mL. Possible reasons for false positivity were papillary thyroid cancer in 17%, renal insufficiency in 8.3%, Hashimoto thyroiditis in 17% and β-blocker use in 33%. Positive predictive value for the PG test (>100 pg/mL) was 25% in the entire series. The cost of adding calcitonin measurement (±PG stimulation) to the preoperative work-up, resulted in €912.68 per MTC patient to detect the disease. CONCLUSION: Basal calcitonin measurement together with PG stimulation in cases of basal calcitonin >10 pg/mL detects MTC in 0.62% of patients with nodular thyroid disease.
Calcitonin* ; Diagnosis ; Hashimoto Disease ; Humans ; Pentagastrin ; Renal Insufficiency ; Thyroid Diseases* ; Thyroid Gland* ; Thyroid Neoplasms ; Thyroid Nodule