The effects of a 70% methanolic extract and its fractions obtained from Eleutherococcus, and effects of exercise on oxidative enzyme activity in skeletal muscle, superoxide dismutase activity and lipid peroxidation were studied for 6 weeks using male ICR mice. At the age of 11 weeks, 70 mice were divided into six groups: a non-exercise group (control), a group administered the 70% methanolic extract (MeOH), a group administered a water-soluble extract (water), a group administered an n-BuOH extract (n-BuOH), a group administered an EtOAc extract (EtOAc) and a group given running exercise (exercise) . Eleutherococcus extracts were given p, o, at 170 mg/kg per day (6 days/week) for 6 weeks.
After 6 weeks of training (1 h/day, 6 days/week at 15 m/min, on a flat floor without any slope), succinate dehydrogenase (SDH) activity in gastrocnemius muscle was increased significatly in the exercise group compared with the control group. SDH activity showed an increasing tendency in groups given Eleutherococcus extracts compared with the control group (n-BuOH>water>MeOH>EtOAc>control) . Malate dehydrogenase (MDH) activity in the exercise group was significantly different from that in the control group at P<0.005. In the water and n-BuOH groups, MDH activity was significantly greater than in the control group, whereas an increasing tendency was shown in the McOH and EtOAc groups. Muscle superoxide dismutase (SOD) activity in the exercise, McOH, water and n-BuOH groups was significantly greater than in the control group, and hepatic SOD activity was slightly higher in the exercise, McOH and water groups in comparison with the control group, although these differences were not significant. After endurance training, hepatic lipid peroxidation (LPO) was decreased by 17% in the exercise group. In the n-BuOH and EtOAc groups, a significant decrease was observed in hepatic LPO.
These results suggest that endurance training and administration of Eleutherococcus extracts enhance the activities of oxidative enzymes in skeletal muscle and also SOD in mice, resulting in improved aerobic metabolic rates, and also might intensify the functions of the host defense system against injury caused lipid peroxidation.

The present study was carried out on mice and rats to examine the effects of running and swimming on immune responses, particularly IgE antibody and hemagglutinin (HA) production. In the experiment with running mice, four-week old mice were divided into four groups. The first group of mice started running at the age of four weeks (E4 group), the second group started running at the age of seven weeks (E7 group), the third group started running at the age of 10 weeks (E10 group), and the fourth group was a control that received no treatment. In the experiment protocol, each group was subjected to running exercise until the age of 13 weeks. Each group of mice was forced to run at a speed of 15m/min on a flat floor with no slope for 60min a day. In the E4 group, IgE antibody production was suppressed without affecting HA production. In the E7 and E10 groups, neither IgE antibody production nor HA production was affected. In the experiment with swimming rats, seven-week old rats were divided into two groups: the swim group and the control group. The swim group was forced to swim for five days for three 15-min sessions a day loaded with an iron ring weighing 3% of the body weight. The control received no treatment. In the swim group, IgE antibody production was suppressed without affecting HA production. From these results, it might be concluded that running exercise and swimming exercise from early childhood will provide favorable influences on some asthmatic diseases by suppressing IgE antibody production.

The effects of a 70% methanolic extract and its fractions obtained from Eleutherococcus, and effects of exercise on oxidative enzyme activity in skeletal muscle, superoxide dismutase activity and lipid peroxidation were studied for 6 weeks using male ICR mice. At the age of 11 weeks, 70 mice were divided into six groups: a non-exercise group (control), a group administered the 70% methanolic extract (MeOH), a group administered a water-soluble extract (water), a group administered an n-BuOH extract (n-BuOH), a group administered an EtOAc extract (EtOAc) and a group given running exercise (exercise) . Eleutherococcus extracts were given p, o, at 170 mg/kg per day (6 days/week) for 6 weeks.
After 6 weeks of training (1 h/day, 6 days/week at 15 m/min, on a flat floor without any slope), succinate dehydrogenase (SDH) activity in gastrocnemius muscle was increased significatly in the exercise group compared with the control group. SDH activity showed an increasing tendency in groups given Eleutherococcus extracts compared with the control group (n-BuOH>water>MeOH>EtOAc>control) . Malate dehydrogenase (MDH) activity in the exercise group was significantly different from that in the control group at P<0.005. In the water and n-BuOH groups, MDH activity was significantly greater than in the control group, whereas an increasing tendency was shown in the McOH and EtOAc groups. Muscle superoxide dismutase (SOD) activity in the exercise, McOH, water and n-BuOH groups was significantly greater than in the control group, and hepatic SOD activity was slightly higher in the exercise, McOH and water groups in comparison with the control group, although these differences were not significant. After endurance training, hepatic lipid peroxidation (LPO) was decreased by 17% in the exercise group. In the n-BuOH and EtOAc groups, a significant decrease was observed in hepatic LPO.
These results suggest that endurance training and administration of Eleutherococcus extracts enhance the activities of oxidative enzymes in skeletal muscle and also SOD in mice, resulting in improved aerobic metabolic rates, and also might intensify the functions of the host defense system against injury caused lipid peroxidation.

To explore the possibility of incorporating oriental medicine and medical hydrology in the educational programs of medical, nursing and pharmaceutical schools, a questionnaire on the attitude of medical students (group A, N=70; group B, N=77), nursing students (group C, N=64; group D, N=61) and pharmaceutical students (group E, N=172) who had not yet received any practical medical education was circulated. The results showed that about 50% of the students did not recognize the term “medical hydrology, ” and about 10% of them did not recognize the term “oriental medicine.” Seventy-five percent of the group A medical students and 93% of the group B medical students were interested in oriental medicine, and these rates were higher than those who were interested in medical hydrology (49% (67%)). About 50% of the nursing and pharmaceutical students were interested both in oriental medicine and medical hydrology. Eighty-two percent of group A and 86% of group B medical students hoped to attend lectures on oriental medicine, and these rates were higher than those among nursing and pharmaceutical students. Between 49% and 60% of the students of all three groups hoped to attend lectures on medical hydrology. This rate was lower than that of those who hoped to attend lectures on oriental medicine. In general, the rate of those who had a positive image of oriental medicine was higher among medical and pharmaceutical students. However, there were no significant differences in the rates of those who had a positive image of medical hydrology among different groups of students. In all student groups, the rate of those who answered that both oriental medicine and medical hydrology are “relatively effective” was the highest.

A self administered survey on bathing and nearly drowning accidents in the bathtub was conducted among subjects consisting of 216 members of an aged person's club (153 males and 63 females, 73.7±4.9 years of age) for the purpose of utilizing the results for guidance in bathing for elderly persons. The subjects were bathing almost every day. The total bathing time was 20min and the time spent in the bathtub was 11min. With regard to the preference of bathing temperature, 50.4% of males and 33.3% of females answered that they like hot bathing (P<0.05). The ratios of the subjects who bathe at water temperatures over 42°C in the cold season were 39.0% of males and 21.0% of females (P<0.05). Only 4.2% of the subjects bathe below the waist. The ratios of the subjects who frequently bathe after drinking were 9.2% of males and 1.9% of females. The ratio of the subjects who bathe alone at home was 94.1%. The ratios of the subjects in this survey who had nearly drowned in the bathtub while bathing at home was 4.3%. A nearly drowning accident occurred primarily when the subject got fatigued (44.4%) or physical condition of the subject was bad (44.4%). The ratio of the subjects who had nearly drowned in a large bathtub of a hotel was 1.4%. No subjects had experienced a nearly drowning accident in the bathtub of a public bath. These results suggested that old persons, particularly males, bathe under rather unsafe conditions.

Eighty healthy males aged from 26 to 34 years were studied to evaluate the effects of regular physical training on body composition, respiratory functions, circulatory functions, blood constituents, and physical fitness. The physical training consisted of jogging, volleyball, handball, socker, judo, fencing, and others. The combination of these sports were assigned to all the subjects to be performed for 130 minutes every week-day from April, 1979 to January, 1980.
1) The subjects had, on the average, 518 g of carbohydrate, 125 g of protein including 74 g of animal protein, and 85 g of fat summing up to 3300 kcal a day. These nutrients intake was 30% to 50% excess over the normal value for male Japanese of the corresponding age. Body weight, however, did not change and body fat decreased in spite of large excess food intake. Serum HDL-cholesterol increased and atherogenic index decreased. These facts lead to a conclusion that the noxious effects of overeating can be cancelled by physical activity.
2) Pulse wave velocity of the aorta which reflects the elasticity of the aortic wall decreased. This means that changes in the physical property of the aorta due to aging process can be reversed through physical training. Decrease in pulse wave velocity dose not always mean the regression of atherosclerosis, but the additional findings such as decrease in body fat and in atherogenic index and increase in HDL-cholesterol support the possibility of regression of aterosclerosis by physical activity.
3) The results of physical fitness test indicated marked improvement of physical abilities which reflect muscular strength, muscular power, muscular endurance, body flexibility, agility, anaerobic power, and aerobic power.