AIM: To compare the safety between phacoemulsification and manual small incision cataract surgery ( MSICS ) combined with silicone oil removal in previously vitrectomized eyes.?METHODS:A retrospective comparative no-inferiority study to 162 patients ( 162 eyes ) who undergone cataract surgery, either phacoemulsification or MSICS combined with silicone oil removal which had pars plana vitrectomy.?RESULTS:There were no statistically significant different in hypotony between phacoemulsification group ( 21 patients;18. 91％) and MSICS group (8 patients;15. 68％) (P= 0. 666). There was also no statistically significant different between two group in 1mo retinal reattachment rate;8 patients (7. 2％) in phacoemulsification group had redetachment compared with 9 patients ( 17. 64％) in MSICS combined with silicone oil removal group ( P =0. 055).? CONCLUSION: MSICS combined with silicone oil removal has non-inferiority result to phacoemulsification combined with silicone oil removal in hypotony, leakage, choroidal detachment and retinal reattachment rate.