1.Inherited thrombophilia profile in patients with recurrent miscarriages: Experience from a tertiary care center in north India.
Narender KUMAR ; Jasmina AHLUWALIA ; Reena DAS ; Meenakshi ROHILLA ; Sunil BOSE ; Hari KISHAN ; Neelam VARMA
Obstetrics & Gynecology Science 2015;58(6):514-517
The cause of recurrent miscarriage (RM) remains unexplained in approximately 30% to 50% cases. The association of inherited thrombotic factors and RM patients has not been documented from the northern part of India. A total of 40 patients had been investigated for inherited thrombophilia workup (protein C, protein S [PS], antithrombin III, and factor V Leiden [FVL] mutation) over a period of 10 years (2005 to 2014). RM patients were divided in to three groups. Group I (only 1st trimester loss), group II (only 2nd and 3rd trimester), and group III (mixed). Each group comprised of the following numbers of patients respectively: I, 24; II, 2; III, 14. Heterozygous FVL mutation was found in 10% (4/40) cases. PS deficiency was detected in 2.7% (1/37) cases. In the present study FVL and PS were seems to be associated with a subset of patients however further studies with larger numbers of patients are recommended for better evaluation.
Abortion, Habitual*
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Antithrombin III
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Factor V
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Female
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Humans
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India*
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Pregnancy
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Protein S
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Tertiary Care Centers*
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Tertiary Healthcare*
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Thrombophilia*