1.Research progress on the multiple myeloma related peripheral neuropathy
Journal of Leukemia & Lymphoma 2013;22(3):188-190
Peripheral neuropathy (PN) is a major complication of multiple myeloma (MM),and is caused by MM itself and the drugs used to treat the disease.The complexity of PN differentials and subjective symptoms have made the diagnosis and treatment of PN difficult.
2.3D construction and printing of bone tissue engineering scaffolds based on CT data
Haotian YUAN ; Shuman SHI ; Xiaoxiao ZHANG ; Jing LI ; Zhe WU
The Journal of Practical Medicine 2016;32(14):2319-2322
Objective To study 3D construction and printing of bone tissue engineering scaffolds by bone defect modeling on Mimics software based on CT data. Methods CT data of jaw bone defect from patients were acquired and the images were segmented using threshold segmentation combined with region growing . The three dimensional model was reconstructed by Boolean operation. The individual 3D digital model was reconstructed with internal structure by combining with computer; preparing poly-lactic acid scaffold in virtue of 3D technology. Results Using the Mimics software, we successfully constructed a 3D digital reconstruction model of bone defect based on CT data. The constructed scaffold model with certain internal form and structure was matched with the bone defect of patients, and the constructed model was exported onto STL standard format, which may be in common use. Conclusion The 3D digital model of bone defect scaffolds may effectively be reconstructed based on the CT data using Mimics software and computer aided design.
3.Effectiveness of different doses of dexamethasone combined with thalidomide on multiple myeloma
Haotian SHI ; Fan ZHOU ; Jian HOU ; Lieping GUO ; Wei WEI ; Yizi ZHANG
Journal of Leukemia & Lymphoma 2010;19(7):410-411
Objective To evaluate the efficacy and side effects of standard-dose of dexamethasone and low-dose dexamethasone combined with thalidomide in treatment of multiple myeloma. Methods Thirtynine patients with multiple myeloma were randomly divided into 2 groups, who were treated with chemotherapy of thalidomide (200 mg/d) plus dexamethasone (40 mg d1-46728 days in standard-dose group and 20 mg dl-4d/28 days in low-dose group), for a total of 4 courses. The efficacy, survival time and adverse events were compared between the two groups. Results Complete remission rate, partial remission rate and overall response rate of the standard-dose group were 26.3 %, 35 % and 75 %, respectively; and those of the low-dose group were 15.8% , 36.8 % and 68.4 %, respectively. No statistical difference between the two groups (P >0.05 ) was observed. Lung infections, blood pressure elevation, blood glucose elevation, shingles and other adverse reactions in the standard-dose group were statistically higher than those in the low-dose group (P <0.05). Conclusion Efficacy on multiple myeloma of standard-dose and low-dose dexamethasone are similar, but adverse reactions are significantly increased.
4.A continuous low-dose cyclophosphamide and prednisone regimen for multiple myeloma with severe complications
Fan ZHOU ; Jian HOU ; Haotian SHI ; Jianfeng ZOU ; Wei WEI ; Yizi ZHANG ; Shengling YANG
Journal of Leukemia & Lymphoma 2008;17(5):353-355
Objective To assess the efficacy and tolerability of continuous low-dose cyclophosphamide and prednisone regimen(CP)as salvage therapy for multiple myeloma patients with severe complications.Methods The CP regimen consisted of oral cyclophosphamide at 50 mg and oral prednisone at 15 mg daily.The patients were withdrawn if the response was invalid or not improved after 6 months,and follow-up was carried on if CR maintained for 6 weeks.A total of 23 consecutive patients received the CP regimen,with 18 patients having severe complications,and 5 patients unwilling to accept conventional chemotherapy because of severe infection.All patients had received one to four regimens before.Results Among 23 patients with CP regimen,the overall response rate(CR+VGPR+PR)was 61%,with 1 CR,4 VGPR,9 PR,3 MR and 6 PD.The quality of life and physical conditions were improved significandy.Conclusion Our data showed that CP was an effective,well-tolerated,and convenient regimen as salvage therapy for MM with severe complications.
5.Continuous low-dose cyclophosphamide and prednisone treatment of 84 cases relapsed and refractory multiple myeloma
Lieping GUO ; Fan ZHOU ; Wei WEI ; Yizi ZHANG ; Haotian SHI ; Chenhui LIN ; Lu LI ; Nan JIANG ; Jian HOU
Journal of Leukemia & Lymphoma 2012;21(5):290-293
Objective To evaluate the efficacy andtolerability of continuous low-dose cyclophosphamide and prednisone treatment of relapsed and refractory multiple myeloma. Methods84 relapsed and refractory multiple myeloma patients were enrolled, including 46 males and 38 females, the assess patients of 81 cases with average age of 69.7 (45-91)years. They were treated continuous with oral cyclophosphamide (50 mg/d) and prednisone (15 mg/d) and monthly follow-up.ResultsAverage follow-up time were 23.5(1-71)months.The assessed patients were 81 cases,with 52 cases (64.2 %) responded.There were 2 cases(2.5 %)CR,21 cases(25.9 %) of PR,29 cases(35.8 %)MR,19 cases(23.5 %)NC and 10 cases (12.3 %)PD.The median time to response was 2 months.In the patients who responded to the treatment,the median progression-free survival(PFS)and overall survival (OS) were 18(95 %CI 12.8-23.2),29(95 %CI 24.1-33.9)months.In the non-responding patients,the PFS and OS were 4(95 % CI 2.2-5.8) and 6(95 % CI 4.9-7.1)months.Two groups were statistically significant(P<0.05).The most common toxicities included fatigue,nausea, neutropenia, hyperglycemia and lung infection. No patient withdrew from the study because of toxicity. Conclusions Continuous low-dose cyclophosphamide combined prednisone is a treatment options for relapsed and refractory MM patients.
6. Clinical features and prognosis of 93 elderly patients with multiple myeloma
Haimin CHEN ; Fan ZHOU ; Wei WEI ; Rong PENG ; Haotian SHI ; Jian HOU
Chinese Journal of Hematology 2017;38(9):744-748
Objective:
To explore the clinical features and prognostic factors of elderly MM patients.
Methods:
A retrospectively analysis of clinical characteristics in 93 newly diagnosed MM patients with more than 70 years of old between August 2011 and August 2016. Based on age, basic activities of daily living scale, instrumental activities of daily living scale, Charlson comorbidity index at diagnosis, patients were divided into three groups: Fit (score=0,
7.Dignity and health from the perspective of public ethicsl
Jun SHI ; Haotian NIU ; Qin LIU
Modern Hospital 2023;23(12):1840-1844,1848
In epidemic prevention and control,people from epidemic areas are easy to be stigmatized and discriminated,and the dignity of patients may be offended intentionally or unintentionally in the treatment process.In such a world where dignity is still generally ignored,ignored and discriminated against,how to maintain and promote human dignity in epidemic prevention and control has become a public ethical problem.There is no conflict between epidemic prevention and control and human digni-ty,but mutual promotion.The prevention and control measures and policies that fully respect human dignity can be better under-stood,supported and cooperated by individuals.From the perspective of dignity,special respect and care should be given to vul-nerable groups in the epidemic situation,so as to provide medical and health services to vulnerable groups in a dignified way.
8.Genomics approaches decode natural products synthesis.
Chinese Journal of Biotechnology 2019;35(10):1889-1900
Novel natural products have always been the most important sources for discovery of new drugs. Since the end of the 20th century, advances in genomics technology have contributed to decode and analyze numerous genomes, revealing remarkable potential for production of new natural products in organisms. However, this potential is hampered by laboratory culture conditions. Therefore, the integration of all these new advances is necessary to unveil these treasures, addressing the rise in resistance to antibiotics. In this review, we discuss the strategies of genome mining, inducing the expression of silent biosynthetic gene clusters and construction of biological chassis.
Animals
;
Biological Products
;
metabolism
;
Biosynthetic Pathways
;
genetics
;
Genome
;
genetics
;
Genomics
;
Multigene Family
;
genetics
9.Progress of in vivo Experiments on Biomechanical Properties of Periodontal Ligaments
Haotian SHI ; Xin LIU ; Bin YAN
Journal of Medical Biomechanics 2019;34(2):E219-E224
Understanding the biomechanical properties of periodontal ligament is of great significance for orthodontic treatment. Due to the complexity of periodontal ligament structures, previous studies mainly used in vitro experiments, which had limitations. In order to obtain accurate and actual data, in vivo experiments on biomechanical properties of periodontal ligaments will become a trend of development in the future. In this article, the method, types, progress, advantages and disadvantages of in vivo experiments on biomechanical properties of periodontal ligaments were reviewed and prospected.
10.Changes of urinary porphyrin metabolites before and after operation for colorectal cancer and their correlation with prognosis
Tao WANG ; Shuangfa NIE ; Jun XUE ; Haotian SHI ; Chengyao WANG ; Xiaofeng HU ; Jiandong FEI ; Yongzhu AN
Chinese Journal of Postgraduates of Medicine 2020;43(6):488-491
Objective:To investigate the changes of porphyrin metabolites in urine of patients with colorectal cancer before and after operation and their correlation with prognosis.Methods:One hundred patients with colorectal cancer were collected in First Affiliated Hospital of Hebei North University from June 2016 to December 2016, urine was collected before operation, 1 week after operation, 1 year after operation and before recurrence. The contents of urinary porphyrin metabolites of uroporphyrinogenI (UP Ⅰ) and coproporphyrinogen Ⅲ(CP Ⅲ) were detected by high performance liquid chromatography. Toanalyse the changes of UPⅠ and CPⅢ levels before and after operaction of colorectal cancer and their correlation with clinicopathologicalcharacteristics,and the recurrence and metastasis after operation.Results:The levels of UPⅠ and CPⅢ in urine of patients with colorectal cancer after operation were significantly lower than those before operation [(66.80 ± 17.62) μmol/g vs. (35.58 ± 9.32) μmol/g, (20.14 ± 3.14) μmol/g vs. (10.38 ± 0.85) μmol/g] ( P<0.05). The levels of UP Ⅰ and CP Ⅲ in urine of patients with Dukes C/D stage were significantly higher than those with Dukes A/B stage [(45.26 ± 5.26) μmol/g vs. (28.56 ± 3.45) μmol/g, (86.57 ± 6.58) μmol/g vs. (52.48 ± 3.36) μmol/g], the levels of UP Ⅰand CPⅢ in urine of patients with lymph node metastasis were significantly higher than those without lymph node metastasis [(45.44 ± 5.46) μmol/g vs. (30.27 ± 6.07) μmol/g, (86.67 ± 6.87) μmol/g vs. (56.10 ± 11.08) μmol/g], there were significant differences ( P<0.05). Urinary levels of UPⅠ and CPⅢ were independent risk factors for recurrence and metastasis of colorectal cancer after operation ( OR=1.149 and 1.065, P<0.05). Conclusions:Porphyrin metabolites (UPⅠ and CPⅢ) in urine may serve as a new marker for assessing colorectal cancer.