1. Correlations between striatal dopamine transporter distribution, glucose metabolism and clinical symptoms in Parkinson′s disease
Fangyang JIAO ; Jun TAO ; Jinju SUN ; Haosu ZHANG ; Yi LUO ; Jianliang WEN ; Zhenfan ZHAO ; Zhiqiang XU ; Rongbing JIN
Chinese Journal of Nuclear Medicine and Molecular Imaging 2019;39(6):349-355
Objective:
To investigate the correlations among striatal dopamine transporter (DAT) distribution, glucose metabolism and Parkinson′s disease (PD) clinical symptoms.
Methods:
Twenty-five clinically confirmed idiopathic PD patients (17 males, 8 females, age: (59.8±9.2) years) who underwent 11C-2-beta-carbomethoxy-3-beta-(4-fluorophenyl)tropane (CFT) and 18F-fluorodeoxyglucose (FDG) PET imaging from January 2015 to December 2016 were reviewed. The detailed clinical scores were systematically collected from all patients. Correlations between DAT distribution, glucose metabolism and clinical symptoms were evaluated at global and voxel levels using Pearson correlation analysis.
Results:
There were significantly positive correlations between the PD-related pattern (PDRP) value and unified PD rating scale (UPDRS) motor scores, non-motor symptoms scale (NMSS) scores, activity of daily living scale (ADL) scores (