Objective To explore and evaluate the value of transcatheter closure procedure in con-genital heart diseases. Methods Transcatheter closure was performed in 12 patients with congenital heart diseases including 6 ventricular spetal defect (VSD), 4 atrial septal defect (ASD), 2 patent ductus arteriosus (PDA), by the Amplaztzer occlusion device under local or general anesthesia. Results The procedure was successful in all patients outcoming with the disappearance of cardiac murmur. All of them could get out of the bed within 6 to 12 hours postoperatively, and were discharged from hospital after 4 to 6 days.Conclusions Transcatheter treatment of congenital cardiac defects by Amplatzer occlusion device is less traumatic, with good effect, simul taneously.