Objective To explore the prognostic value of hemoglobin-albumin-lymphocyte-platelet(HALP)score and geriatric nutritional risk index(GNRI)in elderly patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A retrospective analysis was conducted on the clinical and follow-up data of 228 elderly AECOPD patients who were admitted to the De-partment of Respiratory and Critical Care Medicine,the Second Affiliated Hospital of Zhengzhou University from September 2018 to March 2022.After discharge,the patients received 1-year follow-up,and were divided into two groups based on their prognosis:good progno-sis group(n=130)and poor prognosis group(n=98),and the data were compared between the two groups.The predictive effect of HALP score and GNRI on poor prognosis in elderly AECOPD patients was analyzed by receiver operating characteristic(ROC)curve.The correlation analysis was used to investigate the relationship between HALP score and GNRI and C-reactive protein(CRP),interleukin-6(IL-6),procalcitonin(PCT),NRS2002,length of hospital stay and prognostic outcomes.Results The levels of body mass index,lymphocyte count,hemoglobin,albumin,GNRI,and HALP score in the good prognosis group were higher than those in the poor prognosis group,and the age,length of hospitalization,NRS2002,neutrophil count,CRP,IL-6,PCT,sputum culture,chest CT combined with inflammation were lower than those in the poor prognosis group,and the differences were statistically significant(P＜0.05).The results of ROC curves indicate that the area under the curve(AUC)of HALP score and GNRI were 0.868 and 0.682 respectively.The results of correlation analysis showed that in elderly patients with AECOPD,both HALP score and GNRI were negatively correlated with CRP,PCT,NRS2002,length of hospitalization,prognostic outcomes,sputum culture,and chest CT with inflammation(P＜0.05),and GNRI was also negatively correlated with IL-6(P＜0.05).Conclusion HALP score and GNRI can predict the prognostic outcome of elderly pa-tients with AECOPD.