Meningocerebral haemorrhage due to the rupture of malformation of cerebral arterio venous fistula is neurosurgical emegency that requires the radical management to prevent from relapsed haemorrhage. Currently in Vietnam, the operation for malformation removal is an unique technique. The restrespective study on 16 cases suffered the rupture of malformation of cerebral arterio venous fistula in Vietduc during 1999-2000 showed the encourage results. 81.3% of malformations were radically removed, 18.7% of malformation were partial removed and experienced ligation of artery the outcomes: good (81%) and no death
abnormalities ; Arteries ; surgery

A retrospective study on 14 case of ruptured cerebral cranial carotid aneurysm operated in Viet Duc Hospital during 1998 - 2000 has shown that the clinical outcome and method of operation found well in 78.6% of patients. The time for operation was usually late (often 2-3 weeks of bleeding).
Aneurysm, Ruptured ; Cerebral Arterial Diseases

3 cases of intracranial aneurismal residue following clipping at Viet Duc Hospital were studied. The causes of this condition were anatomical and technical. It is necessary to identified prior surgery the cause of hemorrhage, to limit the disruption of aneurism, to expose entirely the neck of aneurism before the setting of clip and to explore throughly the place of clip- Anterigraphy or systematic Xray control should be made for checking the results
Intracranial Aneurysm ; etiology ; Aneurysm ; Intracranial Arterial Diseases

This association had been reported for long time with a frequency of 2.7-23% of cases of intracerebral arteriovenous connection. This association increases the risk of cerebral meningo hemorrhage. 3 cases of cerebral meningo hemorrhage associated with intracerebral arteriovenous connective malformation were studied retrospectively and treated at Viet Duc Hospital from January 1999 to January 2004. The presence of aneurysm in cerebral arteriovenous connection was an important predictive factor for the hemorrhage possibility, leading to cerebral hemorrhage
Aneurysm ; Arteriovenous Malformations ; Intracranial Arteriovenous Malformations ; abnormalities

Based on the traditional fear extinction training paradigm, the retrieval-extinction para-digm rewrites fear memory within the reconsolidation window,and reduces their fear response by decreasing the valence of fear stimulus. From the perspective of psychology,the main reason of addicts relapse is that the intensive memory of the painful experience inspired when protracted withdrawal symptoms of drug depend-ence. The reduction of the sensitivity of drug related memory, which is the key of drug detoxification is to change the memory caused by drug related cues. The retrieval-extinction paradigm provides no drug treatment and a new non-invasive model for addicts,and a new perspective to reduce the relapse rate,and to improve the quality of life of addicts. We can do empirical research which using memory retrieval-estinction paradigm on drug addicts in the future.The memory retrieval paradigm can be applied to empirical research in drug ad-dicts in future.

Objective To investigated the efficacy of minimally invasive technique combined with anterolateral thigh flap in repairing skin and soft tissue defects of leg and foot.Methods Anterior thigh flap was used to repair 20 cases of skin and soft tissue defects of leg and foot,the lesions defect area was 3.9 cm × 7.4cm-11.4 cm × 20.6 cm.Given the appropriate minimally invasive techniquesurgical treatment,the effect of follow-up was observed after operation.Results The supply valve area healed.The postoperative flaps of 20cases of patients all survived,no vascular crisis occurred.The color of skin flap was normal,close to normal skin color,and the elasticity of the skin was good,no crack,no fat,no pigmentation and other complications occurred,and no effect on shoes and ankle joint activities.Excellent and good rate of overall assessment flap was 90％(excellent in 12 cases,good in 6 cases);excellent and good rate of Mazur ankle function evaluation was 95％(excellent in 12 cases,good in 7 cases).Conclusion The minimally invasive technique combined with anterolateral thigh flap is a more ideal method to repair the leg and foot soft tissue defects.

Objective To investigate the changing patterns of serum IL-6, IL-10, IL-23 and osteopontin in patients with smear-negative pulmonary tuberculosis before and after treatment and their clinical implication.Methods A total of 43 patients with smear-negative pulmonary tuberculosis and 40 healthy controls were included in this study. Enzyme-linked immunosorbent assay (ELISA) was conducted to measure the levels of serum IL-6, IL-10, IL-23 and osteopontin in healthy individuals and patients before and after anti-tuberculosis treatment for 2, 4 and 6 months.Results The levels of serum IL-6, IL-10, IL-23 and osteopontin in patients with smear-negative pulmonary tuberculosis were signiifcantly higher than those in control group (P<0.05). After treatment for two months, the levels of serum IL-6, IL-10, IL-23 and osteopontin signiifcantly decreased in patients with smear-negative pulmonary tuberculosis (P<0.05). The serum IL-10 and osteopontin were nearly restored to normal levels in patients after four months treatment and there were no signiifcant difference compared with those in control group (P>0.05). The levels of serum IL-6 and IL-23 gradually decreased after treatment, and restored to normal at six months. There was no signiifcant difference compared with those in control group (P>0.05). Conclusions Serum IL-6, IL-10, IL-23 and osteopontin levels in patients with smear-negative pulmonary tuberculosis can be used as sensitive indicators for assessment of tuberculosis disease activity and therapeutic effect of anti-tuberculosis drugs.

The ghrelin is an endogenous ligand of the growth hormone (GH) secretagogue receptor,which can regulate the secretion of GH,stimulate the appetite,adjust the energy metabolism,and improve the cardiovascular function.Children with congenital heart disease (CHD) usually suffered from malnutrition and growth retardation,which were connected with insufficiency of energy intake,poor absorption,and increase of nutritional requirement,anatomy and the changes of hemodynamics.Many infants with CHD gradually present ventricular dysfunction and growth restriction in their early childhood,which consequently lead to severe complications.Ghrelin is valuable in the early detection of potential CHD,plays an important role in improving the state of malnutrition and protecting the cardiac function,and provides an important reference to explore the new drug therapy for CHD.This review summarized the effects and significances of ghrelin on growth and cardiac function in infants with CHD.

Absent in melanoma 2(AIM2),as a cytoplasmic DNA sensor,can perceive the cytoplasmic dsDNA which released by the cells infected with DNA virus or bacteria.AIM2 will be raised by Apoptosis-associated speck-like protein containing a CARD to produce inflammation complex,activate of Caspase-1,promote the maturation,and secretion of IL-1β and IL-18,or lead to pyroptosis.AIM2 plays an importation role in initiating immunity.Recent research shows that AIM2 has an influence on the occurrence and progress in tumor,it acts as a tumor suppressor and inhibits tumor progression in liver and breast carcinoma;However,AIM2 shows the carcinogenic effect of promoting tumor development on cervical carcinoma and oral squamous cell carcinoma.These results contribute to the diagnosis and prognosis of malignant tumor.

Proceeding from the problems confronting hospitals, the paper first offers an analysis of the relationship between the coordination of the "three reforms" and the reform of the management system of public hospitals and then provides some views on the steps for the coordination of the "three reforms" including the reform of the management system of public hospitals, the breakthrough point of the issue in particular. The author holds that the breakthrough point of the coordination lies in reforming the mode of payment and the compensation mechanism of hospitals. The current method of payment by service items ought to be changed into the mode of total quantity control and payment by the amount of service so as to form a policy and operational environment wherein hospitals will seek substantial development on their own initiative. Under such an environment, hospitals can achieve maximum benefits only by minimizing the costs and the primary goals of the coordination of the "three reforms" can thus expect to be attained. On the basis of this, relevant models for the reform of the management system of public hospitals can be promoted. system; Public; Reform