1.Application of the CRISPR/Cas system in gene editing and nucleic acid detection of parasitic diseases: a review
Shuning YAN ; Shuo YANG ; Hanyin YANG ; Yi XIN ; Bin XU ; Wei HU ; Yan LU ; Bin ZHENG
Chinese Journal of Schistosomiasis Control 2024;36(3):314-320
CRISPR/Cas system, an adaptive immune system with clustered regularly interspaced short palindromic repeats, may interfere with exogenous nucleic acids and protect prokaryotes from external damages, is an effective gene editing and nucleic acid detection tools. The CRISPR/Cas system has been widely applied in virology and bacteriology; however, there is relatively less knowledge about the application of the CRISPR/Cas system in parasitic diseases. The review summarizes the mechanisms of action of the CRISPR/Cas system and provides a comprehensive overview of their application in gene editing and nucleic acid detection of parasitic diseases, so as to provide insights into future studies on parasitic diseases.
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