OBJECTIVE: To provide medical staff with medication information concerning compatibility of hospital injections.METHODS: Based on the "Junwei No.1" hospital information system,a database system comprising system maintenance,information maintenance and comprehensive inquiry that can provide information of compatibility of hospital injections was developed through setting up database and sorting the information of hospital injections.RESULTS & CONCLUSIONS: This system is characterized by low cost,high transferability,friendly user interface,flexible inquiry and convenient maintenance,and it can facilitate medical staff's convenient,quick and accurate mastering of the information of hospital injections so as to provide better service for the patients.

OBJECTIVE:To analyze one case of pericardial pain induced by drug combination of omeprazole so as to provide reference for drug combination in the clinic. METHODS:A 79-year-old male patient was admitted because of stage Ⅲ hypertension,coronary heart disease,acute attack of chronic bronchitis in Dec. 2 of 2009. He was treated with omeprazole and pericardial pain was observed during treatment. ADR caused by omeprazole were put forward in the clinic. RESULTS & CONCLUSION: Omeprazole combined with other drugs can easily cause ADR for example,pericardial pain. The universality of ADR induced by drug combination of omeprazole should be further confirmed because of limited sample.

OBJECTIVE:To study the ex vivo adsorption of montmorillonite powder to ofloxacin.METHODS:Different dosages of ofloxacin and montmorillonite powder were mixed with artificial gastric juice and artificial intestinal juice,respec?tively,which were filtrated after warmed at(37?0.5)℃in water bath for1hour,the content changes of ofloxacin were de?termined by ultraviolet spectrometry.RESULTS:The adsorption rates of montmorillonite powder to ofloxacin in artificial gastric juice and in artificial intestinal juice were(99.76?0.01)%and(99.55?0.02)%,respectively.CONCLUSIONS:Montmorillonite powder has strong adsorption to ofloxacin in both artificial gastric juice and artificial intestinal juice,there?fore,which should not be administered simultaneously in the clinic.

Formula granule of traditional Chinese medicine (TCM) has been characterized as a safe medication with the advantages of accurate dosage and easy to carry.In this study,references over current status of the development of TCM formula granule were retrieved,so were those of the market situation and its application to intelligent pharmacy of TCM.Then the key problems restricting the development of the application of TCM granules were discussed,in hope of providing a reference for the development and its application to the intelligent pharmacy of TCM.

Objective To examine the correlation of serum neutrophil gelatinase-associated lipocalin (NGAL) with dialysis adequacy,microinflammatory state and iron metabolism,and to assess the value of NGAL in identifying the dialysis adequacy in maintenance hemodialysis (MHD) patients.Methods A total of 150 MHD patients and 50 healthy control people were enrolled in the study.Clinical data were collected and serum NGAL,CRP,transferrin saturation,serum ferritin were measured.MHD patients were divided into adequacy group and non-adequacy group according to spKt/V value.Serum NGAL between two groups was compared and correlation of NGAL with spKt/V,inflammatory factors,and other clinical indexes was examined by Pearson,multivariate regression Logistic model and area under curve (AUC) of ROC.MHD patients were followed up for 3 months.Similar correlation analysis was carried out before and after follow up between two groups.Results Serum NGAL of MHD patients was higher compared to healthy people [(445.45±50.34) μg/L vs (50.02 ±6.45) μg/L].Among 150 MHD patients,95 were classified into adequacy group,while 55 into non-adequacy group according to spKt/V value.Serum NGAL was significantly higher in adequacy group as compared to non-adequacy group [(589.14±56.34) μg/L vs (360.13±46.23) μg/L,P＜0.05].Serum NGAL was positively correlated to spKt/V,CRP,TSAT [r=0.652,0.825,0.785,all P＜0.05],but not to serum ferritin.Serum NGAL was also correlated to spKt/V,CRP,TSAT by multivariate regression Logistic model.AUC showed that NGAL level could reflex the condition of dialysis adequacy.During the follow up,all adequacy patients remained the same adequacy status.Thirty-eight out of 55 non-adequacy patients were qualified for complete adequacy after intervention.The serum NGAL before and after intervention was (368.14±56.21) μg/L and (360.56±46.23) μg/L respectively without significant difference.Conclusions Serum NGAL is obviously higher in MHD patients with dialysis adequacy compared to those without dialysis adequacy.Serum NGAL is positively correlated to spKt/V,CRP,TSAT.NGAL can reflex the condition of dialysis adequate in MHD patients.

BACKGROUND:Stem cel is a kind of pluripotent cels with self-replication ability, which can differentiate into various cels under certain conditions. Furthermore, stem cels are rich in a variety of growth factors, which can induce the generation of vessels and nerves, and improve the blood supply of lower limbs, thereby achieving the treatment and preventions of lower limb ischemia OBJECTIVE:To summarize and compare the recent achievements in the theory and therapeutic efficacy of stem cels from different sources in the treatment of diabetic foot. METHODS:The first and second authors retrieved PubMed, Sciencedirect and Medline databases for relevant articles published from January 2000 to January 2015. The key words were “diabetic foot, pathogenesis, stem cel therapy” in English. Initialy, 186 articles were retrieved, and finaly 44 articles were included in result analysis. RESULTS AND CONCLUSION:Stem cels can be a new choice for the treatment of diabetic foot. After stem cel therapy, corresponding symptoms have been aleviated, including the generation of new blood vessels and the reshaping of the colateral vessels, the improvement of motor nerve conduction velocity and nerve reflex, the improvement of the sense of skin pain and temperature, and pain relief. It is stil unclear whether alogeneic stem cels are safe or not, but autologous stem cels, especialy bone marrow mesenchymal stem cels, can be better able to repair damaged vessels and nerves and restore the microcirculation of blood supply. Currently, we need to do more basic and clinical researches to solve the folowing problems: to confirm the effectiveness and safety of stem cel therapy for diabetic foot; to identify whether there is a difference in the differentiation and secretory activity between stem cels in diabetic patients and ordinary people; to give ful play to the treatment of diabetic foot.

AIM: To observe the effect of orthokeratology on the positive relative accommodation of juvenile with myopia.

METHODS: Retrospective analysis of cases. All 122 cases(244 eyes)of juvenile with myopic from September 2016 to December 2017 in our hospital were analyzed. 63 cases were corrected by orthokeratology lens and 59 cases were corrected by glasses. data of the binocular positive relative accommodation before treatment and 6mo after treatment were compared between the two groups.

RESULTS:Before treatment, the average PRA value of the orthokeratology group(-0.83±0.23)D and the average PRA value of the glasses group(-0.77±0.24)D were no significant difference(t= -1.457, P>0.05). There was no significant difference between the two groups before treatment in eye axis(orthokeratology group 24.84±0.90mm, glasses group 24.78±0.86mm, t=0.550, P>0.05). PRA in the orthokeratology group -2.27±0.37D was significantly higher than that in the pre-treatment group -0.83±0.23D(t=37.070, P<0.001). There was no significant difference in PRA -0.83±0.24D at the end of 6mo compared with that before treatment -0.77±0.24D,(t=1.565, P>0.05). After treatment, the PRA of orthokeratology group was better than that of glasses group, and the difference was statistically significant(t=-25.271, P<0.001). The eye axis of the orthokeratology group 24.86 ±0.91mm was significantly higher than that of the control group 24.84±0.90mm(t=-2.453, P<0.05)at the end of 6mo. The eye axis of the glasses group 24.97±0.86mm was significantly different from that before treatment 24.78±0.86mm(t=39.135, P<0.001). There was no significant difference in the eye axis between the orthokeratology group and the glasses group after 6mo(t=-0.932,P>0.05).

CONCLUSION: The corrected visual acuity of juvenile myopia by orthokeratology was significantly higher than that by using glasses 6mo after treatment, but there was no significant difference between the two groups in eye axis during 6mo.

AIM: To study the effect of residual triamcinolone acetonide(TA)to intraocular pressure(IOP)and retinal thickness in patients after vitrectomy.

METHODS: Retrospective study. The medical data of 83 patients(83 eyes)after vitrectomy in our hospital from October 2016 to October 2017 were analyzed retrospectively. The 83 patients were treated with TA as vitreous dyeing. Vitreous cavity was not filled with silicone oil or gas. Totally 32 eyes were observed that triamcinolone acetonide was residual in vitreous cavity, 51 eyes were not observed the residual, and after 1wk and 3mo, intraocular pressure and macular center concave thickness(CMT)of two groups was compared.

RESULTS: There was no statistical difference in preoperative average intraocular pressure between two groups(t=0.56, P>0.05). After 1wk, IOP of no residual group was 15.48±3.8mmhg, IOP of residual Group was 20.09±6.14mmhg. IOP of residual group were higher than IOP of no residual group, the difference was statistically significant(t=3.81,P<0.05). After 3mo, postoperative average IOP was 13.75±2.35mmhg, IOP of residual Group was 16.26±2.52mmhg, IOP of residual group was higher than IOP of no residual group, the difference was statistically significant(t=4.54, P<0.05). After 1wk, the average CMT of no residue group was 240.57±42.69μm, that of residual group was 215.03±18.38, and the difference was statistically significant(t=3.75,P<0.05). After 3mo, there was no statistical significance on the average CMT between no residual group and residual group(t=0.21, P>0.05).

CONCLUSION: The residual triamcinolone acetonide as a dyeing agent during vitrectomy may raise the risk of postoperative intraocular pressure in short term, and after 3mo without any significant effect on the thickness of macular center.

Purpose: To investigate the cytokine concentrations of aqueous humor in patients with exudative age-related macular degeneration (AMD) and diabetic macular edema (DME). Methods: Fifty-seven subjects were included in the exudative AMD, DME and control groups, each group has 19 patients. Aqueous levels of cytokines epidermal growth factor (EGF), vascular endothelial growth factor-C (VEGF-C), monocyte chemoattractant protein-1 (MCP-1), hepatocyte growth factor (HGF), interleukin (IL)-3, IL-8, IL-6, IL-12p40, intercellular adhesion molecule 1 (ICAM-1) were investigated in each groups. Kruskal-Wallis test and Mann-Whitney U test were performed to compare cytokine concentrations. Results: Aqueous levels of EGF, VEGF-C, MCP-1, HGF, IL-3, IL-8 were significantly higher in exudative AMD group than control group (p = < 0.0001, < 0.0001, 0.004, 0.015, < 0.0001, 0.014) and EGF, VEGF-C, IL-3, IL-8 were significantly higher in DME group than control group (p = < 0.0001, < 0.0001, < 0.0001, 0.005). In the comparison between the exudative AMD and DME groups, EGF was significantly higher in the exudative AMD group (p = 0.001). Conclusions Various cytokines were increased in patients with exudative AMD and DME. In particular, EGF showed a higher level in exudative AMD than in DME.

Laser photocoagulation is one of the important methods for treating retinal diseases, and retinal laser technology continues to advance. For decades, researchers have been striving to find a laser treatment that can minimize tissue damage while achieving optimal results. With low toxicity, low scattering light, strong penetrating power, small compared with the traditional laser damage, light reaction and no pain, the 577 nm subthreshold micropulse laser(SML)turns this goal into reality and ushers in a new era of laser treatment for fundus diseases. This article reviews the concept, mechanism, related parameters and clinical application progress of 577 nm SML in a variety of retinal diseases, aiming to provide references for clinical treatments.