Objective To examine the effectiveness of cognitive therapy on orthodontic patients with body image disturbance (BID).Methods 21 orthodontic patients with BID in study group re ceived routine orthopedic treatment and cognitive therapy,and 15 orthodontic patients with BID in control group received only routine orthopedic treatment.All patients were tested with Symptom Checklist 90 (SCL-90),Cognitive Bias Questionnaire (CBQ),Self-Rating Depression Scale (SDS),Self-Rating Anxiety Scale (SAS),and Body Image Questionnaire (BIQ) at prior and post treatment.Results SAS and SDS scores in the study group were decreased after treatment,and SDS decrease in the study group was larger than that in control group.The factor scores of both groups on the SCL- 90were decreased after treatment,and most factor scores decrease in study group was larger than that in control group.Three dimensions (except for function impairment) of the BIQ were improved in the study group as compared with control group.Cognitive styles were improved on the study group as compared with control group.Conclusions The cognitive therapy can improve cognitive bias and mental health of patients with BID.

Objective To verify the applicability of serum creatinine(Cr)reference interval and the distri-bution characteristics of Cr under different influencing factors,and to explore the difference of different for-mulas for estimating glomerular filtration rate(eGFR)in chronic kidney disease and to validate the new for-mula.Methods Data from the laboratory information system of the hospital on September 1,2022 to August 31,2023 on healthy examinees were retrieved.The Skewness-Kurtosis method was used to determine the nor-mality of data,Box-Cox method was used to convert skewed data,and interquartile range method was used to remove outliers.Mann-Whitney U test,Kruskal-Wallis one-way ANOVA,and covariance analysis were used to compare differences in Cr by gender,age,and season.The applicability of the current Cr reference range was verified based on industry standards in China.Data of chronic kidney disease patients hospitalized during the same period were selected and the CKD-EPICr2009 formula currently in use in the laboratory was used as the standard to validate the newly developed MMB-eGFR formula in France.Spearman correlation,Deming re-gression,and Bland-Altman plot were used to analyze the correlation,linear relationship,and consistency of the results of two estimation formulas.Results Data of 54 710 healthy subjects who underwent the physical examination were included.There were statistically significant differences in Cr between genders,ages,and seasons.Cr level in males was significantly higher than that in females(P＜0.001).There were statistically significant differences among the age groups except for the age range of 20-＜30 and 30-＜40(P＜0.001),and Cr level increased with age.The Cr levels in males and females varied in a"checkmark"and"inverted trapezoidal"pattern between the four seasons.The above data were all used for the applicability verification of the Cr reference interval,and the pass rates of each subgroup were greater than 90％.336 patients with chronic kidney disease were screened and included in the study for comparison between CKD-EPICr2009 and MMB-eGFR results.There was a significant correlation between the results of two estimation formulas(r=0.943,P＜0.001),and there was a linear relationship with a consistency of 92.86％.Conclusion There are statistically significant differences in serum Cr levels in terms of age,gender,and season.The Cr reference range provided in the industry standards is applicable to the local area.The MMB-eGFR and CKD-EPICr2009 formulas have high consistency and are suitable for the local area.

The rapid development of point-of-care testing (POCT) in clinical laboratories has brought challenges to the unified management in the hospital. There are many problems, such as how to ensure the ability and qualification of POCT operators, how to improve the quality management awareness of human, machines, materials, methods and environment in the process of POCT in clinical laboratories, how to help the clinical laboratories in the hospital to carry out POCT comparison, and how to strengthen the information construction of POCT in the hospital. Thus, this article reviews the practice and experience of POCT management in our hospital on POCT quality assurance and the problems existing in POCT in clinical departments, proposes suggestions and solutions to strengthen the unified management of POCT in clinical laboratories and establish POCT quality management documents and to improve quality awareness. We hope to provide references for hospital administrators, medical departments, nursing departments, quality control departments and other functional departments on the quality management of POCT in the hospital, and find helpful answers to the puzzles of clinical laboratory in POCT, so as to make joint efforts to standardize the quality management of POCT in the hospital to ensure the accuracy of testing results.