1.Identification and characterization of atypical porcine pestivirus genomes in newborn piglets with congenital tremor in China
Hanqin SHEN ; Xiangcong LIU ; Pengfei ZHANG ; Lei WANG ; Yanling LIU ; Leyi ZHANG ; Pengshuai LIANG ; Changxu SONG
Journal of Veterinary Science 2018;19(3):468-471
Recently, a novel atypical porcine pestivirus (APPV) in pig was reported. In this study, two APPV strains, APPV-China/GZ01/2016 (GZ01) and APPV-China/GD-SD/2016 (GD-SD), were identified in two newborn piglet herds with congenital tremor from China. The open reading frame of the two strains shared an 83.5% nucleotide identity. Phylogenetically, the APPV strains were placed into two groups: GZ01 belonged to group I and GD-SD belonged to group II. A high viral load was detected in the cerebellum (quantification cycles < 26). Further studies should be carried out to thoroughly elucidate the development of congenital tremors caused by APPV.
Cerebellum
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China
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Genome
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Humans
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Infant, Newborn
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Open Reading Frames
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Pestivirus
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Tremor
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Viral Load