Objective To explore the relationship between serum microRNA(miR)-122 and microRNA(miR)-558 levels and cardiac function and heart rate variability in patients with chronic heart failure(CHF).Methods A total of 100 patients with chronic heart failure who were hospitalized in Wuhan Dongxihu District Poeple's Hospital from January 2019 to January 2022 were regarded as the study group,and 100 healthy individuals who underwent physical examinations in the hospital during the same period served as the control group.The real-time fluorescence quantitative PCR method was applied to detect the expressiou levels of serum miR-122 and miR-558 in two groups.The heart rate variability and cardiac function indicators of the two groups were compared.Pearson method was applied to analyze the correlation between serum miR-122 and miR-558 expression levels,and heart rate variability and cardiac function indicators in patients with chronic heart failure.Logistic regression was applied to analyze the risk factors affecting chronic heart failure.Results Compared with the control group,the serum miR-122(0.86±0.19 vs 1.07±0.16),heart rate variability indicators,and left ventricular ejection fraction(LVEF)of patients with chronic heart failure were decreased(t=3.844～15.448),and the expression level of miR-558(1.28±0.27 vs 1.02±0.12)and left ventricular end diastolic volume index(LVEDVI),left ventricular end systolic volume index(LVESVI)were increased(t=6.794～9.358),and the differences were statistically significant(all P＜0.05).The expression level of serum miR-122(1.19±0.23,1.04±0.21)in patients with functional grades Ⅰ to Ⅱ was higher than that in patients with grades Ⅲ to Ⅳ(0.68±0.16,0.53±0.15),while the expression level of miR-558(0.93±0.24,1.21±0.26)was lower than that in patients with grade Ⅲ-Ⅳ(1.42±0.27,1.64±0.29),with significant differences(qmiR-122=3.751～14.568,qmiR-558=3.929～11.194.all P＜0.05).The serum miR-122 level in patients with chronic heart failure was positively correlated with heart rate variability indicators and LVEF(r=0.337～0.573),but negatively correlated with LVEDVI and LVESVI(r=-0.385,-0.323).Serum miR-558 was negatively correlated with heart rate variability indicators and LVEF(r=-0.646～-0.246),but positively correlated with LVEDVI and LVESVI(r=0.528,0.547).Serum miR-122[OR(95％CI)=0.528(0.328～0.850)]and miR-558[OR(95％CI)=2.845(1.364～5.933)]were influencing factors for chronic heart failure(P＜0.05).Conclusion The expression levels of serum miR-122 and miR-558 in patients with chronic heart failure were closely related to heart rate variability and cardiac function,indicating that serum miR-122 and miR-558 may be influencing factors of chronic heart failure.

As the state vigorously promotes the high-quality development of hospitals and improves people's medical ex-perience,the patient-centered hospital should make full use of technological resources such as the Internet,5 G and artificial in-telligence,vigorously develop mobile medical services and artificial intelligence services,transform and optimize the diagnosis and treatment process,and streamline all links before,during and after diagnosis so as to provide better data services to the pa-tient to ensure that they can get things done with greater ease.The patients'medical experience and hospital management effi-ciency can be greatly improved.In this study,specific measures to create a new diagnosis and treatment model through the con-struction of smart hospital platform were expounded in order to provide references for related research and policy formulation of other Chinese medical institutions.