1.Effect of fecal microbiota transplantation on intestinal immunity
International Journal of Pediatrics 2019;46(4):263-267
Fecal microbiota transplantation (FMT) is a treatment of transplanting a healthy human intestinal flora to the patient's gastrointestinal tract,in order to treat diseases by reconstructing the normal function of the intestinal flora.In recent years,fecal microbiota transplantation attracted more attention since many studies have demonstrated that fecal microbiota transplantation has great clinical value in the treatment of inflammatory bowel disease,autoimmune disease,irritable bowel syndrome,metabolic syndrome and other diseases.Intestinal tract which is an important human intestinal digestive organ has complex immune functions.Normal intestinal flora plays an important role in promoting the development of the immune system,maintaining normal immune function,and synergistically antagonizing pathogens.The fecal microbiota transplantation affects the receptor's immune function by reconstructing disorganized intestinal flora.In this paper,the effect of fecal microbiota transplantation on the intestinal immune system is reviewed.
2.Comparison of serum lipid profiles and the risk factors between the Guangxi Bai Ku Yao and Han nationalities
Jianting GAN ; Ruixing YIN ; Qiming FENG ; Shangling PAN ; Weixiong LIN ; Dezhai YANG ; Shuquan LI ; Yuming CHEN ; Jing TAN ; Hanjun YANG ; Hong CHEN ; Yaoheng HUANG
Chinese Journal of Endocrinology and Metabolism 2009;25(1):66-67
The levels of total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, apolipoprotein (APO) A1 and APO B were lower in Bai Ku Yao than those in Han nationalities (all P<0.01). There was no significant difference in serum triglyceride levels and the ratio of Apo A1 to Apo B between two nationalities. Dyslipidemia was positively correlated with body mass index, waist circumference, total energy and total fat intakes, and inversely correlated with degree of physical activity and total dietary fiber intake in both ethnic groups. In addition, dyslipidemia was also positively correlated with age and alcohol consumption in Han, but not in Bai Ku Yao.
3.Analysis of GCDH gene variant in a child with Glutaric aciduria type I.
Hanjun YIN ; Qiong XUE ; Suyue ZHU
Chinese Journal of Medical Genetics 2022;39(1):39-42
OBJECTIVE:
To explore the genetic basis for a neonate affected with Glutaric aciduria type I (GA-I).
METHODS:
Targeted capture and high-throughput sequencing was carried out for the proband and her parents. Candidate variants were verified by Sanger sequencing.
RESULTS:
The proband was found to harbor compound heterozygous variants of the GCDH gene, namely c.523G>A and c.1190T>C, which was derived from her father and mother, respectively.
CONCLUSION
The compound heterozygous variants of the GCDH gene probably underlay the GA-I in the patient.
Amino Acid Metabolism, Inborn Errors/genetics*
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Brain Diseases, Metabolic/genetics*
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Child
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Female
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Glutaryl-CoA Dehydrogenase/genetics*
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High-Throughput Nucleotide Sequencing
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Humans
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Infant, Newborn
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Mutation