1.Relationship between TMPRSS4 and tumor invasion and metastasis
Yuxiang WANG ; Xinyang HE ; Wei LIANG ; Hanhui YAO ; Chuanhai ZHANG ; Jiajia GUAN
International Journal of Surgery 2013;40(7):478-481
Type Ⅱ transmembrane serine proteases 4 (TMPRSS4) is a novel type Ⅱ transmembrane serine protease.Present study showed that its expression was related with tumor invasion and metastasis,although its oncogenic significance and molecular mechanisms are still unknown.In this review,the author try to introduce its structure,biological function and mechanism in tumor invasion and metastasis.
2.Epidemiological characteristics of five cases of importing yellow fever in Fujian province and strategies for prevention and control of infection in hospital
Lifen HAN ; Zhiping ZHAO ; Xiaoling YU ; Zhongqiong QIU ; Cailing HE ; Shengcan GUAN ; Shouyun XIE ; Yuhai WANG ; Lu LIU ; Hanhui YE ; Chen PAN ; Qin LI
Chinese Journal of Infectious Diseases 2016;34(11):665-669
Objective To analyze the epidemiological and clinical characteristics of 5 patients with importing yellow fever ,and to explore the preventive and control strategies of infection in hospital .Methods The epidemiological and clinical characteristics of 5 cases of importing yellow fever in Infectious Disease Hospital of Fujian Medical University from March 18th to April 6th in 2016 were retrospectively reviewed and analyzed .Results Five patients were all from Angola Luanda .One of them was vaccinated before going aboard ,and the others were vaccinated 1—10 days before disease onset in Angola .All of them were bitten by mosquitoes ,and their onset date ranged from March 11th to March 27th ,before returned to Fujian .The main clinical symptoms were fever ,chilly ,shivering ,fatigue ,arthrodynia ,headache ,and liver and kidney injury .At manifestations ,two patients had positive nuclear acid of yellow fever virus in serum samples and 3 patients were positive in urine samples .All of these patients were negative for dengue virus and Zika virus testing ,meanwhile no plasmodium was found in blood smears .All patients were cured and discharged . Conclusions There is risk of yellow fever transmission in Fujian Province . Prevention and control of the disease should be focus on improving the ability of finding and coping with the importing cases .Vaccination and hygiene knowledge propagation should be given for those who are going to epidemic country/area .Emergency monitoring and control of mosquitoes are necessary .
3.The epidemiological and clinical features of 403 cases with dengue fever in Fuzhou City
Lifen HAN ; Xiaoling YU ; Shengcan GUAN ; Wen ZHOU ; Yuhai WANG ; Ling ZHENG ; Qin LI ; Hanhui YE
Chinese Journal of Infectious Diseases 2018;36(7):411-416
Objective To analyze the epidemiological and clinical characteristics of 403 local cases with dengue fever , and to provide guidance for dengue fever's prevention , diagnosis and treatment . Methods The epidemical data ,clinical characteristics ,laboratory results ,therapy and outcomes of 403 cases with dengue fever treated in Mengchao Hepatobiliary Hospital of Fujian Medical University ,Fuzhou from July to November 2016 were collected and analyzed retrospectively .Results Among the 403 cases , 56 cases (13 .89% ) were younger than 20 years old ,160 cases (39 .71% ) were 21 to 50 years old ,and 187 cases (46 .40% ) were over 50 years old .The peak incidence period of dengue fever was from August to October ,accounting for 94 .29% of the cases .The clinical classification was dominated by typical dengue fever (98 .01% ) .Most of the cases had sudden onset .The main clinical symptoms included fever in 391 cases (97 .02% ) , body aches in 355 cases (88 .09% ) , and rash in 156 cases (38 .71% ) . All patients were tested for serology and etiology of dengue virus at the early stage of disease .Among them , the positive rate of NS1 antigen was 95 .04% ;the positive rate of IgM antibody was 13 .90% ,and the positive rate of IgG antibody was 8 .19% . Thrombocytopenia was founded in 332 cases (82 .38% ) .Neutrophil count decreased in 293 cases (72 .70% ) , w hite blood cell count decreased in 274 cases (67 .99% ) .Aspartate aminotransferase increased in 256 cases (63 .52% ) and alanine aminotransferase increased in 146 cases (36 .23% ) .Creatine kinase elevated in 130 cases (32 .26% ) and prothrombin time was prolonged in 40 cases (9 .93% ) .A total of 289 cases (82 .75% ) had bilateral lesions in both lungs and 25 cases (6 .20% ) had pleural effusions . Color doppler ultrasound found 46 cases (11 .41% ) of hepatomegaly ,84 cases (20 .84% ) of splenomegaly ,8 cases (1 .99% ) of a small amount of ascites . Conclusions Most of the 403 cases of dengue fever show typical clinical manifestations .Dengue fever mainly affects the blood system ,liver ,heart ,lung ,kidney ,skeletal muscle system ,and immune system . Clinicians should carefully observe the condition ,master the warning signs of severe dengue fever ,and achieve early identification and timely treatment of severe cases ,thereby reducing the mortality rate .
4.Transfer of polyfoliate perforator flap of fibular hallux in reconstruction of multiple digit-tip defects
Shunan DONG ; Chengwei LIU ; Jiyong JIANG ; Yuzhi YU ; Long PENG ; Hanhui GUAN ; Dong HUANG
Chinese Journal of Microsurgery 2024;47(1):44-47
Objective:To evaluate the clinical effectiveness of the reconstruction of multiple digit-tip defects with transfer of polyfoliate perforator flaps of the fibular hallux.Methods:From January 2019 to June 2022, 15 patients had undergone reconstruction surgery for multiple digit-tip defects using polyfoliate perforator flaps of ipsilateral fibular hallux, with the first dorsal metatarsal artery as the pedicle, in the Department of Upper Limb Repair and Reconstruction Surgery, Guizhou Hospital of Beijing Jishuitan Hospital. The patients were 10 males and 5 females and aged 20 to 45 years old. Eight patients had the defects of thumbs and index fingers, 4 of thumbs and middle fingers, 2 of thumb, index and middle fingers and 1 of thumb, index and ring fingers. All the 15 digit injuries had nail bed defects to which reconstructive surgery were required. For the flaps of dorsal artery, flaps were 1.8 cm×2.0 cm-2.0 cm×3.1 cm in size and for those of plantar artery, the flaps sized 1.5 cm×2.0 cm-2.5 cm×3.0 cm. Donor site defects in the hallux were reconstructed with free superficial circumflex iliac perforator flaps. Postoperative follow-up lasted until 30th June 2023 and included visits to the outpatient clinic, WeChat and telephone reviews to assess the appearance, function and sensation recovery of the digits.Results:All the 15 flaps survived. During the 6 to 24 months (16 months in average) of postoperative follow-up, the appearance and texture of all flaps were found close to the healthy digits, with good nail growth and without deformity. TPD were found between 8.0 mm and 12.0 mm. The donor sites on the great toes that reconstructed with superficial circumflex iliac artery flaps were all survived well, and the incisions were satisfactorily healed without the functions of walking, running or jumping being significantly affected.Conclusion:The use of polyfoliate perforator flaps of fibular hallux for reconstruction of multiple digit-tip defects is an ideal surgical method due to the consistency of vascular anatomy, ease with flap harvest, similarity in the normal digital skin texture, and the capability to include a nail bed with the flap. A single donor from the hallux can simultaneously reconstruct two defects of digit-tip, making it an excellent treatment in the reconstruction of small-to medium-sized composite tissue defects in multiple digits.