Objective: The aim of this study was to investigate the association of the CYP19A1 rs7176005 single nucleotide polymorphism (SNP) with breast cancer risk and with clinicopathologic features of tumors. Methods: This study was conducted by including 138 patients with breast cancer (cancer group), those who diagnosed as primary breast cancer after operation by pathology. There were 293 cases in the group of benign breast disease which was presented as a solid mass by the color ultrasound and pathologically diagnosed as "fibroadenoma or adenosis" (benign breast disease group), the cases were paired with breast cancer patients by age±5 in the same period, and there were 259 cases in the group of healthy control who received routine physical examination during the same period and were paired with breast cancer patients by age±5 without any detection of breast related diseases (healthy control group) at West China hospital between September 2012 and November 2016. The CYP19A1 rs7176005 SNP was detected by a direct sequencing method. Hardy-Weinberg test was used to analyze the genetic balance of the 3 groups. Chi square test was used to compare the distribution of rs7176005 genotypes between the 3 groups, and the differences of clinicopathological features in breast cancer patients carrying different genotypes. Results: The ages of the breast cancer cases, the benign breast disease group and the healthy control group were (44.69±8.09), (42.33±11.44) and (41.92±9.61) years old, respectively. Hardy-Weinberg equilibrium test identified that the composition ratios of alleles C and T in breast cancer group, benign breast disease group and healthy group were not statistically significant (χ² values were 0.83, 0.34 and 0.04, respectively, P values were 0.363, 0.561, and 0.852, respectively). All the three groups met the genetic balance, had consistency and could represent the population. Among the 138 cases of breast cancer, the CYP19A1 rs7176005 SNP was significantly associated with the diameter of the tumor (P=0.031). The majority of tumor size was <2 cm in patients who carrying TT and CT genotypes, and the proportion was 75% (12/16) and 58% (40/69), respectively. While those patients with TT genotype were mainly >2 cm and ≤5 cm, and the proportion was 51% (27/53). The distribution of TNM stage among patients with different genotypes was also statistically significant (χ²=11.19, P=0.025). The most common stage was Ⅱ in Patients who carrying CC and CT genotypes, and the proportion was 45.3% (24/53) and 52.2% (36/69), respectively. While those patients with TT genotype was mainly in stage Ⅰ and the proportion was 56.3% (9/16). Conclusion Though the CYP19A1 rs7176005 SNP is not associated with breast cancer development, breast cancer patients with the C allele exhibit a high tumor growth rate and large diameters.

Objective To investigate the effect of erector spinae plane block on ultrasound-based hemodynamic parameters of the arteries of the four limbs and biochemical stress indicators in patients with thoracoscopic lobectomy.Methods A total of 120 patients with thoracoscopic lobectomy were randomly divided into study group and control group,with 60 cases in each group.The study group re-ceived erector spinae plane block during surgery,while the control group received conventional anes-thesia measures.Pulmonary function indicators[peak expiratory flow rate(PEFR),forced vital ca-pacity(FVC),forced expiratory volume in the first second(FEV1)],ultrasound-based hemodynamic parameters of the arteries of the four limbs(maximum systolic velocity,minimum diastolic velocity,mean velocity,arterial pulsatility index,and arterial resistance index),stress indicators[cortisol(Cor),norepinephrine(NE),angiotensin Ⅱ(Ang Ⅱ),and adrenocorticotropic hormone(ACTH)],and analgesic effect were compared between the two groups at different time points[before an-esthesia induction(T0),after extubation(T1),and after drainage tube removal(T2)].Results FEV1,FVC and PEFR in both groups were significantly lower at T,and T,than at T0,and FEV1,FVC and PEFR in the study group were significantly higher than those in the control group at T,and T2(P＜0.05).The maximum systolic velocity and arterial resistance index in both groups were significantly lower at T1 and T2 than at T0,while the minimum diastolic velocity,mean velocity and arterial pulsatility in-dex were significantly higher at T1 and T2 than at T0(P＜0.05).The maximum systolic velocity and arterial resistance index in the study group were significantly higher than those in the control group at T1 and T2,but the minimum diastolic velocity,mean velocity and arterial pulsatility index were sig-nificantly lower than those in the control group(P＜0.05).Cor,ACTH,Ang Ⅱ and NE in both groups were significantly higher at T2 than at T0,and Cor,ACTH,Ang Ⅱ and NE in the study group were significantly lower than those in the control group at T2(P＜0.05).The Prince-Henry pain score,effective compression times,and actual compression times in the study group were sig-nificantly lower than those in the control group(P＜0.05).Conclusion Application of erector spinae plane block in thoracoscopic lobectomy causes smaller fluctuations in hemodynamic parame-ters of the arteries of four limbs and biochemical stress indicators,with a better anesthetic effect.

Objective To investigate the effect of erector spinae plane block on ultrasound-based hemodynamic parameters of the arteries of the four limbs and biochemical stress indicators in patients with thoracoscopic lobectomy.Methods A total of 120 patients with thoracoscopic lobectomy were randomly divided into study group and control group,with 60 cases in each group.The study group re-ceived erector spinae plane block during surgery,while the control group received conventional anes-thesia measures.Pulmonary function indicators[peak expiratory flow rate(PEFR),forced vital ca-pacity(FVC),forced expiratory volume in the first second(FEV1)],ultrasound-based hemodynamic parameters of the arteries of the four limbs(maximum systolic velocity,minimum diastolic velocity,mean velocity,arterial pulsatility index,and arterial resistance index),stress indicators[cortisol(Cor),norepinephrine(NE),angiotensin Ⅱ(Ang Ⅱ),and adrenocorticotropic hormone(ACTH)],and analgesic effect were compared between the two groups at different time points[before an-esthesia induction(T0),after extubation(T1),and after drainage tube removal(T2)].Results FEV1,FVC and PEFR in both groups were significantly lower at T,and T,than at T0,and FEV1,FVC and PEFR in the study group were significantly higher than those in the control group at T,and T2(P＜0.05).The maximum systolic velocity and arterial resistance index in both groups were significantly lower at T1 and T2 than at T0,while the minimum diastolic velocity,mean velocity and arterial pulsatility in-dex were significantly higher at T1 and T2 than at T0(P＜0.05).The maximum systolic velocity and arterial resistance index in the study group were significantly higher than those in the control group at T1 and T2,but the minimum diastolic velocity,mean velocity and arterial pulsatility index were sig-nificantly lower than those in the control group(P＜0.05).Cor,ACTH,Ang Ⅱ and NE in both groups were significantly higher at T2 than at T0,and Cor,ACTH,Ang Ⅱ and NE in the study group were significantly lower than those in the control group at T2(P＜0.05).The Prince-Henry pain score,effective compression times,and actual compression times in the study group were sig-nificantly lower than those in the control group(P＜0.05).Conclusion Application of erector spinae plane block in thoracoscopic lobectomy causes smaller fluctuations in hemodynamic parame-ters of the arteries of four limbs and biochemical stress indicators,with a better anesthetic effect.