Objective To evaluate the influence of tirofiban to percutaneous coronary intervention.Methods 66 elderly patients with coronary artery disease were treated,they were divided into the study group of 33 cases and the control group of 33 cases.The control group was treated with simple percutaneous coronary intervention treatment, the study group was treated with percutaneous coronary intervention combined with tirofiban.The changes of LVEF, cTnT,and TIMI,symptoms in the treatmeat and the symptoms after 2 years were observed and compared.Results After treatment,the patients'platelet count was to the basic line,the difference was not statistically significant(t =0.353 3,P >0.05).The cTnT,LVEF levels of the study group were significantly better than the control group,the differences were statistically significant(t =5.138 1,8.658 1,all P <0.05).After treatment,the incidence rate of TIM in both two groups were improved compared with before treatment.After treatment,the incidence rate of TIMI 3 of the study group(93.9%) was significantly higher than the control group(69.7%),the difference was statistically significant(χ2 =6.518 5,P <0.05).After treatment,the remission rate of angina of the study group(87.9%) was significantly higher than the control group(60.6%),the difference was statistically significant (χ2 =6.417 8,P <0.05).After 2 years of follow -up , the remission rate of angina and recurrent angina in the study group were significantly better than the control group,the differences were statistically significant (χ2 =5.076 9,3.995 2,all P <0.05).Conclusion The efficacy of percutaneous coronary intervention combined with tirofiban is significant,the prognosis is good,has higher remission,it is suitable for long -term clinical application.