Segmentally distributed cutaneous eruptions and neuralgia are common manifestations of herpes zoster. However, motor loss is another aspect of this manifestation, which is less well known and considered a rare finding. In many cases the loss of motor function may be easily overlooked because the pain is the more prominent feature and the weakness probably goes unrecognized with only a mild impairment of the motor function. We experienced a 71-year-old male patient with a herpes zoster-related motor paralysis of right arm whose clinical features of a weak limb mimicked other spinal motor diseases and confirmed motor involvement using electromyographic (EMG) and motor nerve conduction velocity (MNCV) studies.
Aged ; Arm ; Extremities* ; Herpes Zoster* ; Humans ; Male ; Neural Conduction ; Neuralgia ; Paralysis*

Eosinophilic folliculitis (EF) is regarded as a variant of eosinophilic pustular folliculitis (EPF), because it has a few distinctive clinical features different from those of EPF. EF is generally associated with systemic disorders, such as acquired immunodeficiency syndrome (AIDS) and hematologic malignancies. We have recently experienced a case of EF occurring in a 40 year-old male patient treated with allogenic bone marrow transplantation (BMT) for acute myelogenous leukemia(AML) and achieved a good clinical outcome after a short course of systemic corticosteroid therapy. The immunologic aberration resulting from systemic diseases may play a role in the development of EF.
Acquired Immunodeficiency Syndrome ; Bone Marrow Transplantation ; Bone Marrow* ; Eosinophils* ; Folliculitis* ; Hematologic Neoplasms ; Humans ; Leukemia, Myeloid, Acute* ; Male

19 cases of non-pineal intracranial germ cell tumors were reviewed retrospectively with both radiologic andclinical featurses. The results were as follows: 1. The age distribution was 8 to 32 year old (16 year old of meanage) and the sex distribution shows male predominence(15:4). 2. The histopathologic diagnosis included 11 cases ofgeminoma, 2 cases of mixed germ cell tumor, 1 case of embryonal cell carcinoma and 5 cases of unknown. 3. Thelocation of tumors was the suprasellar region in 8 cases, the left basal ganglia and thalamus in 5 cases, and theright frontal lobe in 1 case. Among 11 cases of geminoma, 6 cases involve the suprasellar region and 3 cases theleft basal ganglia and thalamus. 4. In clinical features, there were visual disturbance, diabetes insipidus,increased ICP signs, motor weakness, hormonal disorders, and personal changes in order. 5. In tumor marker studyof 6 cases of geminoma, 5 cases show increase in HCG, titie, but all 6 cases were normal in AFP titer. 6. In brainCT, most of all revealed well-defined homogeneous high density with or without small central low density andhomogenous enhancement at solid portion,and there was calcification in only case with mixed germ cell tumor.
Age Distribution ; Basal Ganglia ; Brain ; Diagnosis ; Frontal Lobe ; Germ Cells ; Humans ; Male ; Neoplasms, Germ Cell and Embryonal ; Retrospective Studies ; Sex Distribution ; Thalamus

Generalized plane xanthoma is a group of plane xanthomas that appear as yellow to yellow-brown flat patches or slightly elevated plaques with a wide-spread distribution. The disease is frequently associated with multiple myeloma or other reticulo-endothelial malignancies and monoclonal gammopathy with unknown significance, and when accompanied by these hematologic malignancies, normolipoproteinemia is invariably associated. We present a case of generalized plane xanthoma associated with multiple myeloma and type III hyperlipoproteinemia in a 48 year-old woman, and this is the first report in Korean literature.
Female ; Hematologic Neoplasms ; Humans ; Hyperlipoproteinemia Type III ; Hyperlipoproteinemias* ; Middle Aged ; Multiple Myeloma* ; Paraproteinemias ; Xanthomatosis*

Myoepithelial carcinomas are rare, malignant salivary neoplasms in which the tumor cells almost exclusively manifest myoepithelial differentiation. A 50-year-old man presented with an indolent movable submucosal mass of 10 years' duration on the right upper oral mucosa. The diagnosis of myoepithelial carcinoma originated from minor salivary gland was made by histopathologic and immunohistochemical evaluation.
Diagnosis ; Humans ; Middle Aged ; Mouth Mucosa ; Salivary Glands, Minor*

BACKGROUND: Photodynamic therapy(PDT) is a kind of non-invasive photochemotherapy, which is designed to kill the target cells through photodynamic reaction. It has been reported that PDT is very effective in superficial lesions, including extramammary Paget's disease. Yet, there has been no clinical trial for the treatment of extramammary Paget's disease using PDT in Korea. OBJECTIVE: The purpose of this study was to evaluate the effectiveness of PDT in treating extramammary Paget's disease METHOD: Seven patients with anogenital extramammary Paget's disease were treated repeatedly with local PDT using topical ALA 20% and intralesional injection of hematoporphyrin derivative (HpD), and systemic PDT using HpD. Fluences of 125-200J/cm2 and intensities of 50-100mW/cm2 were used. RESULT: The clinical outcomes were disappointing. All the patients experienced only partial responses despite repeated treatments. But side effects were minimal. CONCLUSION: PDT is not effective enough for the treatment of extramammary Paget's disease to be used as a primary therapy. It would be better to use as an adjuvant to other treatment methods. Photodynamic sensitization, also known as photodynamic diagnosis, might help us define a more reliable border of the extent involved and the surgical margin to be excised.
Diagnosis ; Hematoporphyrin Derivative ; Humans ; Injections, Intralesional ; Korea ; Paget Disease, Extramammary* ; Photochemotherapy*

BACKGROUND: Photodynamic therapy(PDT) is a kind of non-invasive photochemotherapy, which is designed to kill the target cells through photodynamic reaction. It has been reported that PDT is very effective in superficial lesions, including extramammary Paget's disease. Yet, there has been no clinical trial for the treatment of extramammary Paget's disease using PDT in Korea. OBJECTIVE: The purpose of this study was to evaluate the effectiveness of PDT in treating extramammary Paget's disease METHOD: Seven patients with anogenital extramammary Paget's disease were treated repeatedly with local PDT using topical ALA 20% and intralesional injection of hematoporphyrin derivative (HpD), and systemic PDT using HpD. Fluences of 125-200J/cm2 and intensities of 50-100mW/cm2 were used. RESULT: The clinical outcomes were disappointing. All the patients experienced only partial responses despite repeated treatments. But side effects were minimal. CONCLUSION: PDT is not effective enough for the treatment of extramammary Paget's disease to be used as a primary therapy. It would be better to use as an adjuvant to other treatment methods. Photodynamic sensitization, also known as photodynamic diagnosis, might help us define a more reliable border of the extent involved and the surgical margin to be excised.
Diagnosis ; Hematoporphyrin Derivative ; Humans ; Injections, Intralesional ; Korea ; Paget Disease, Extramammary* ; Photochemotherapy*

Papillomatous melanocytic nevus is a clinical type of melanocytic nevus, which show a resemblance to seborrheic keratoses both clinically and histopathologically. Therefore, this kind of nevi is also described by the terms of keratotic melanocytic nevus and seborrheic wart-like melanocytic nevus. Characteristic histopathologic findings include epidermal acanthosis, hyperkeratosis, papillomatosis, a lacelike and downward growth of epidermal strands, and horn cysts. We present four cases of papillomatous melanocytic nevi in 3 females and 1 male patients, which did not express estrogen receptors in immunohistochemical study.
Animals ; Female ; Horns ; Humans ; Keratosis, Seborrheic* ; Male ; Nevus ; Nevus, Pigmented* ; Papilloma ; Receptors, Estrogen

Extramammary Paget's disease is a rare malignancy occuring mainly in apocrine gland- bearing areas such as vulva, scrotum, perianal area, and axilla. Histopathologically, the Paget's cells are usually confined within the epidermis and may be associated with underlying adenocarcinoma. Although surgical excision is the treatment of choice, the clinical demarcation of the lesion is still a frequent problem in the treatment of extramammary Paget's disease. We tried photodynamic diagnosis to determine the surgical margin of extramammary Paget's disease and with surgical excision guided by photodynamic diagnosis successfully treated two cases.
Adenocarcinoma ; Axilla ; Diagnosis* ; Epidermis ; Paget Disease, Extramammary* ; Scrotum ; Vulva

Rosacea is a chronic and recurrent inflammatory eruption of the flush areas of the face, particularly the nose, which is characterized by erythema, papules, pustules, and telangiectasia. Although the precise etiology remains as a mystery, various factors including genetic disposition, vascular dysfunction, solar elastotic degeneration, gastrointestinal disturbance, hormonal influences, increased humoral vasoactive mediators, and Demodex folliculorum infestation have been suspected of contributing to this condition. In recent study, it has been reported that a high density of Demodex folliculorum may have a pathogenic role in rosacea, especially in the development of inflammatory lesions. We report an unilateral rosacea-like chronic dermatitis of the left side of the face which was shown to harbor many Demodex folliculorum mites.
Dermatitis ; Erythema ; Mites ; Nose ; Rosacea* ; Telangiectasis