Objective To investigate the short-term improvement of life quality in patients with obstructive sleep apnea hypopnea syndrome(OSAHS)after temperature-controlled radiofrequency ablation(TCFR).Methods Totally 70 patients with OSAHS were diagnosed by polysomnography(PSG)and received TCRF in our department.The Epworth Sleepiness Scale(ESS)and Calgary Sleep Apnea Quality of Life Index(SAQLI)were surveyed before and after the therapy.The results were followed up for six months after the operation.Results The pre-operative scores of ESS was correlated with body mass index(BMI),apnea hypopnea index(AHI),lowest saturation(LSaO2)and the scores of SAQLI(correlation coefficient:0.410,0.371,-0.441,and-0.411 respectively;all P

Objective To study clinicopathologic factors related to central lymph node (CLN) metastasis in different subregions for unilateral papillary thyroid carcinoma (PTC) with clinical N0.Methods A total of 145 PTC cases with clinical N0 treated in the same group of the department of head and neck surgery,Cancer Hospital,Chinese Academy of Medical Science between Jan.2011 and Jan.2014 was analysed retrospectively.Clinicopathologic factors related to CLN metastasis in different subregions were analyzed,including sex,age,tumor size,extrathyroidal extension,and multifocal tumor.Results CLN metastases existed in 57.9％ (84/145) cases and the incidences of ipsilateral paratracheal,pretracheal,and prelaryngeal metastasis were 53.8％,24.1％ and 11.3％ respectively.Right paratracheal lymph node metastasis occurred in anterior (17/38,44.7％)and posterior(12/38,31.6％) to the recurrent laryngeal nerve.Multivariate analysis indicated that extrathyroidal extension(OR =4.49,95％ CI 1.80-11.20,P =0.001) and tumor size (OR =2.17,95％ CI 1.06-4.45,P =0.034) were independent risk factors for ipsilateral paratracheal CLN metastasis ;ipsilateral paratracheal CLN metastasis(OR =2.12,95％ CI 0.08-4.60,P =0.003) was an independent risk factor for pretracheal CLN metastasis.Conclusions A high risk of CLN metastasis especially ipsilateral paratracheal metastasis exists in DTC with clinical N0.Ipsilateral paratracheal,pretracheal and prelaryngeal CLN dissection should be conducted when maximum tumor diameter more than 1 cm or extrathyroidal extension.CLN anterior and posterior to the recurrent larygeal nerve should be removed simultaneously when the ipsilateral paratracheal CLN metastasis at right side.Total thyroidectomy and contralateral paratracheal CLN dissection should be conciderded in multifocal tumor.

Objective To investigate the risks for occult carcinoma in contralateral nodules for unilateral papillary thyroid carcinoma.Methods The study included 157 consecutive cases of unilateral papillary thyroid carcinoma with benign nodules in the contralateral lobe identified by preoperative ultrasound or fine-needle aspiration from January 2011 to December 2013.The patients received total thyroidectomies and neck lymph node dissections.The frequency and predictive factors for contralateral occult carcinoma in these patients were analyzed.Results A total of 68 patients (43.3％) had occult papillary thyroid carcinoma in the contralateral lobe and the maximum diameter of contralateral occult papillary carcinoma ranged from 0.1 to 1.2 cm,including ≤0.5 cm in 56 patients,0.5-1.0 cm in 9 patients and ＞ 1.0 cm in 3 patients respectively.In univariate analysis,occult carcinoma in the contralateral lobe was associated with patient age (x2 =7.266,P =0.007) and pathologically multifocality in the ipsilateral lobe (x2 =5.090,P =0.024),but not with family history,tumor size,thyroid function,Hashimoto's thyroiditis,perithyroidal invasion,multifocality in the ipsilateral lobe,clinically or pathologically node-negative neck.In multivariate Logistic an analysis,age(OR =1.054,P =0.001) and multifocality in the ipsilateral lobe on final pathology (OR =2.443,P =0.021) were independent predictive factors for contralateral occult papillary thyroid carcinoma.Conclusions Occult carcinoma is common in the contralateral "benign" nodules in patients with unilateral papillary thyroid carcinoma especially in young patients or the cases with multifocal tumors.

Objective To evaluate the efficacy of pedicled supraclavicular artery island flaps for head and neck reconstruction.Methods Reconstructive surgeries for head and neck oncologic defects were performed with the pedicled supraclavicular artery island flaps in 10 patients from May 2013 to December 2014 and the cases were review.Among them,6 were performed for hypopharyngeal cancer,2 for oral tongue cancer,1 for oral base cancer and 1 for cervical esophageal cancer.The size of the flaps was measured in (5-8) cm × (6-12) cm.Results Seven flaps survived,one flap failured and two flaps had partial necrosis.Donor sites were closed primarily without morbidity.Conclusion The pedicled supraclavicular artery island flap is an easy harvesting and reliable for head and neck reconstruction,especially suitable for otolaryngo-head and neck surgeon and maxillofacial surgeon in the local hospital.

OBJECTIVETo analyze the clinical features of familial non-medullary thyroid cancers, and to discuss their management.

METHODSSixty thyroid cancer patients with familial non-medullary thyroid cancer (FNMTC) history during Sep. 2003 to Sep. 2012 were collected as study group, and another 60 sporadic thyroid cancer patients were randomly chosen as control. We compared the differences of their clinical features.

RESULTSAll the patients were diagnosed as thyroid papillary carcinoma. The study group included 40 female and 20 male patients. There were 16 cases in stage T1, 37 in stage T3, and 7 in stage T4. The patients were 21-66-year old ( median age 42-years). The control group included 49 female and 11 male patients. The patients were 24- to 78-year old, and the median age was 45.5 years. 43.3% of the patients in the study group and 18.3% of the patients in the control group had bilateral carcinomas (P = 0.003). There were multifocal lesions in 53.3% of the patients in the study group and 35.0% of the control group, local invasion in 73.3% of the patients in the study group and 55.0% of the control group, and coexisting benign thyroid diseases in 81.7% of the patients of the study group and 50.0% of the control group (P < 0.05 for all). There were cervical lymph node metastases in 60.0% of the patients in the study group and 38.3% in the control group (P = 0.018). In the study group, 32 cases were of parent-offspring type and 28 cases of sibling type. Among the parent-offspring type patients, the median onset age of the first generation offsprings was 58 years, and that of the second generation offsprings was 32 years (P < 0.001).

CONCLUSIONSFamilial nonmedullary thyroid cancer, especially in parent-offspring type patients, is more aggressive than sporadic nonmedullary thyroid cancer, and often involves bilateral lobes, has multifocality, and combines with benign thyroid diseases. We recommend a total thyroidectomy for treatment, and to screen all the family members >20 years old, with ultrasonography for early diagnosis and treatment.

Adult ; Aged ; Carcinoma ; pathology ; Carcinoma, Papillary ; Case-Control Studies ; Female ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Thyroid Neoplasms ; pathology