Objective: To observe the intervening effect of resveratrol on coxsackie virus B3m-induced mycocarditis in Balb/c mice and explore its mechanism. Methods: An animal model of viral mycocarditis induced by coxsackie virus B3m (CVB3m) was used, taking ribavirin as control drug, to examine the changes of general condition, mortality, the weights of heart, liver and spleen, serum MDA and NO levels, and cardiac histology in Balb/c mice. Results: By comparison with ribavirin, it was found that in the mice model of viral mycocarditis induced by coxsackie virus B3m resveratrol significantly improved the changes of general condition, mortality, the weights of heart, liver and spleen, serum MDA and NO levels, and cardiac histology. Conclusion: It suggested that resveratrol might have some chemopreventive and chemotherapeutic effects in the treatment of viral mycocarditis.

Objective To compare the health related quality of life (HRQoL) of ileal conduit versus orthotopic ileal neobladder using the FACT-BL scale.Methods One hundred and thirty patients underwent radical cystectomy and urinary diversion for invasive bladder cancer from Jan 2006 to Dec 2010 at our hospital.According to different urinary diversions,patients were divided into ileal conduit (IC) and orthotopic ileal neobladder (NB).HRQoL was assessed using FACT-BL.The following scores calculated from the FACT-BL questionnaire and list:physical well-being ( PWB ),social/family well-being ( SWB ),emotional well-being(EWB),functional well-being( FWB),overall bladder-special subscale and total FACT-BL were included.A high FACT score indicated a high level of HRQoL.The medical records of each patient were then reviewed.Clinical parameters including age,sex,type of diversion and pathological status were recorded and analyzed.Results A total of 94 questionnaires were collected,of these patients 50 had an IC and 44 had an NB.Among the respondents,the age at surgery was significantly younger in NB group than IC group (P =0.014 ).While the percent of males,follow-up years and pathological stage T3 or greater revealed no significant difference.The NB group got significantly higher scores in PWB,SWB,EWB and FACT-BL than the IC group.Which indicated that the HRQoL was higher in patients following orthotopic ileal neobladder.Conclusions The HRQoL was better in patients who followed orthotopic ileal neobladder than those who followed ileal conduit.This may indicate that orthotopic ileal neobladder should be considered first when making a decision about which urinary diversion should be used.

There is hypoxia in malignant glioma tissue,which would promote malignant progress and resistance to chemoradiotherapy.Hyperbaric oxygen can enhance dissolve oxygen in blood.Hyperbaric oxygen may restrain glioma growth through inhibition on cell proliferation,angiogenesis and promotion on apoptosis.Clinical research also found that combination of hyperbaric oxygen and chemoradiotherapy may ameliorate prognosis of glioma patient.But all results of previous studies still need further confirmation from multi-center,prospective,randomly controlled study.

Objective To develop a simple and effective method for monitoring cortical ischemia after temporary occlusion of the parent arteries during anterior circulation intracranial aneurysm surgery. Methods Fifty-two patients with anterior circulation aneurysm (58 aneurysms) received craniotomy from April to November 2008, and at the same time,cortical electroencephalograpby (EEG) and scalp EEG were monitored during the surgery.According to the international 10/20 electrode placement system, scalp electrodes were placed on O1, O2, P3, P4, T5, and T6 for monitoring the changes in the depth of anesthesia. A cortical strip electrode was placed on the cortical surface supplied by the artery that was possibly blocked during the operation, which was used to monitor the possible cortical ischemia. For patients who had cortical EEG suppression after the temporary occlusion of the parent arteries Were compared with the changes of scalp EEG. Whether there were ischemic events in the corresponding supply territory after vascular occlusion were observed after surgery. Results Of the 58 aneurysms, 40 aneurysms and 41 major arteries were occluded temporarily. After being occluded temporarily in 19 arteries of 18 patients, cortical EEG changed significantly,while scalp EEG did not change significantly. Only 9 patients had ischemic events in the corresponding supply territories after the occlusion in the cortical EEG significant change group. The changes in the depth of anesthesia had the consistent impact on cortical and scalp EEG. Conelusions Simultaneous monitoring of cortical and scalp EEG is a simple and effective method for monitoring cortical ischemia during anterior circulation intracranial aneurysm surgery, and may effectively identify the effect of anesthesia on EEG.

Objective:To analyze the clinical characteristics of acute and chronic gastrointestinal bleeding in patients with end-stage renal disease(ESRD)after kidney transplantation,to improve the understanding of the causes,diagnosis,treatment and prevention of this complication,and to improve the management of patients with gastrointestinal bleeding after kidney transplantation.Methods:The clini-cal,imaging and pathological data of patients with gastrointestinal bleeding after kidney transplantation in the Department of Urology of The First Affiliated Hospital of Anhui Medical University from August,2015 to December,2020 were collected.The etiology,early clinical manifestations,abnormal laboratory tests and examinations,treatment procedures,late prevention and treatment measures and outcomes of gastro-intestinal bleeding were retrospectively studied,and the relevant literature was summarized and reviewed.Results:A total of 17 patients were included in this study.Nine patients had chronic small amount of bleeding,hemoglobin gradually decreased,melena and fecal occult blood positive in the early stage,and the general condition was good,vital signs were stable,and were cured by drug treatment.Gastroscopy showed small ulcers with active bleeding foci in 2 cases,and the bleeding was stopped by titanium clips,and the prognosis was good.Gastroscopy showed that the anterior wall longitudinal ulcer at the junction of gastric antrum body was not effective in 1 case,and the small branch of right gastroepithelial artery was embolized,and the patient recovered and discharged after 2 weeks.Gastroscopy showed deep pit ulcer at the lesser curvature of gastric antrum in 1 patient,who underwent distal gastroduodenal artery emboliza-tion and had a good prognosis.Gastroscopy showed huge multiple ulcers in the stomach and duodenal bulb in 2 patients,who underwent subtotal gastrectomy and partial duodenectomy,duodenal stump exclu-sion and remnant gastrojejunostomy.One patient recovered and was discharged,and the other patient died of rebleeding on the 12th day after surgery.Two cases of diverticulum underwent surgical resection of diverticulum,and the prognosis was good.Conclusion:The onset of gastrointestinal hemorrhage in kidney transplant patients is insidious,and the condition is acute or slow,which can cause different de-grees of damage to the patient and the transplanted kidney.Active prevention,early diagnosis,timely drug treatment,if the effect is not good,decisive endoscopic titanium clip hemostasis,transvascular in-terventional embolization,and even surgical treatment can minimize the harm of gastrointestinal bleeding.