We experienced two cases of Hand, Foot and Mouth Disease with vesicular lesions in the oral cavity and maculopapular rash on hands and feet. The diagnosis was confirmed by clinical features and biopsy findings. Also we made a brief review of literatures.
Biopsy ; Diagnosis ; Exanthema ; Foot* ; Hand* ; Hand, Foot and Mouth Disease ; Mouth

No abstract available.
Animals ; Foot* ; Foot-and-Mouth Disease* ; Hand* ; Paralysis*

Hand, foot and mouth disease, a distinctive clinical syndrome caused by a coxsackie virus, is clinically characterized by vesicles appearing on the hands, feet and in the mouth. The infection begins with a fever and mouth lesions consisting of small vesicles surrounded by red areolae on the buccal mucosa, tongue, soft palate and gingiva. The disease usually lasts spontaneously between 7 to 10 days after onset. We observed 20 cases of hand, foot, and mouth disease from July, 12th to September, 4th, 1979 and examined histopathologically and virologically. We have isolated only one viral strain showing cytopathic effect on HeLa cell among the five cases of acute stage and also observed that viral particle in the electronmicroscope.
Fever ; Foot* ; Gingiva ; Hand* ; Hand, Foot and Mouth Disease ; HeLa Cells ; Humans ; Mouth Diseases* ; Mouth Mucosa ; Mouth* ; Palate, Soft ; Tongue ; Virion

Objective: To analyze the spatiotemporal characteristics of hand,foot and mouth disease (HFMD) in China, explore the association of socioeconomic, population and health services factors with the incidence of HFMD in China, and provide information for the prevention and control of HFMD. Methods: Bayesian spatiotemporal model was used to fit the data of HFMD, evaluate the spatiotemporal variation of HFMD, and identify the potential association between the risk of HFMD and social, economic, population and health services. Results: From 2011 to 2018, a total of 17 118 050 HFMD cases, including 2 283 deaths, were reported in China. The reported incidence showed a fluctuating increase trend from 2011 to 2014, and a fluctuating decrease trend from 2014 to 2018. Meanwhile, there was a fluctuating decrease trend of mortality rate. The incidence of HFMD had spatial clustering, with the highest incidence in southern China with hot spot and high risk areas, and the lowest incidence in northwestern China where cold spot and low risk areas were found. The risk for HFMD was associated with GDP per capita (RR=3.54), number of industrial enterprises above designated size of 10 000 people (RR=1.61), urbanization rate (RR=3.00), birth rate (RR=2.36), number of beds in medical institutions per 10 000 people (RR=3.40), and green area in parks per capita (RR=0.57). Conclusions: The hotspot area for HFMD prevention and control in China was in the southeast coastal provinces from 2011 to 2018. In order to reduce the incidence of HFMD, it is necessary to increase the green area in parks per capita while accelerating urbanization process.
Humans ; Animals ; Bayes Theorem ; Foot-and-Mouth Disease ; China/epidemiology* ; Hand, Foot and Mouth Disease/epidemiology* ; Menthol

Epidemiologic Methods ; Hand, Foot and Mouth Disease ; epidemiology ; Humans

OBJECTIVETo explore and study the relationships between the popularity of HFMD and the climate in Qinhuangdao city.

METHODSHFMD cases were collected on a ten-day basis in 2009 in Qinhuangdao city. At the same time, the data about Qinhuangdao's ten-day average temperature and average humidity were provided by the Qinhuangdao Meteorological bureau. Then the collected data were analysed using the great data analysis function in the EXCELE software.

RESULTSThe results showed that the disease of HFMD had a positive relationship with seasons. The cases of HFMD began to rise at the last ten days of March and rised dramatically at the middle ten days of April; In July, the cases of HFMD arrived at peak and then decline gradually. The cases of HFMD in October were quite similar to the cases of HFMD in March. Then in November, the cases of HFMD declined rapidly. All these evidences suggested that the peak seasons of HFMD were Spring and Summer.

CONCLUSIONThe situations of HFMD had a significant positive relationship with the conditions of climate, such as high temperature and high humidity.

Enterovirus A, Human ; Hand, Foot and Mouth Disease ; virology ; Humans

Hand, Foot and Mouth Disease ; diagnosis ; therapy ; Health Education ; Humans

Child ; Early Diagnosis ; Hand, Foot and Mouth Disease ; diagnosis ; Humans

Hand, Foot and Mouth Disease ; epidemiology ; prevention & control ; Humans