Kawasaki disease (KD) is one of the most common causes of acquired heart disase in children,the development of which is closely related to the allergic diseases.Recent studies have manifested that the incidence of allergic diseases in children with KD is far higher than that in those children without KD.Meanwhile,the morbidity of KD in allergic children is significantly higher than that in those who do not have family medical history of allergic diseases.By far,the mechanisms causing interaction between KD and allergic diseases still remain unclear.Possible mechanisms include IgE-meditated immune response,release of large quantity of cytokines and inflammatory meditators as well as atopic family history.

Kawasaki disease(KD) is the most common reason for acquired heart disease in children,which is closely related to autoimmune response and the release of cytokines in vascular endothelial cells.Steroids are strongly effective in countering inflammation as well as immune response.In the time of being,it has become a hot spot that steroids play an important role in the initial treatment for acute KD and for incomplete and refractory KD.

Objective To establish a method for detection of selenium in water sample. Methods The method of digestion with nitric acid-hydrogen peroxide was used. Results The calibration curve for selenium was 0-100 ?g/L, r=0.999 2, detection limit 0.42 ?g/L and the recovery of standard addition 98.9% to 102.3%. Conclusion This method is simple, rapid, sensitive and of accurate, the method has been applied to the sample analysis with satisfactory results.

The author makes summary and analysis on the recent situation of domestic plant-polysaccharide anti-tumor research,stating that our country must be further thorough in the plant-polysaccharide anti-tumor function mechanism research.

Objective To explore the effect of transforming growth factor ?_1 (TGF-?_1) on expression of paxillin(Pax) in human kidney proximal tubular epithelial cell line (HKC cells) in different phases. Methods HKC cells cultured in vitro were divided into four groups at random. Control group(C group): HKC cells were cultured with serum free medium (FSM), and TGF-?_1-treated groups (T1, T2, T3 group): HKC cells were cultured with FSM containing 10ng/ml TGF-?_1. In the latter groups, duration of treatment varied as follows: T1 group for 24h, T2 group for 48h, T3 group for 72h. The proliferation of HKC cells induced by TGF-?_1 was assessed by MTT and the expression of Pax was determined. The gene expression of Pax was determined by reverse transcripton polymerase chain reaction (RT-PCR) and the protein expression of Pax was assessed by immunohistochemical staining and Western blot. Results TGF-?_1 could induce the proliferation of HKC cells in a time-dependent manner. In C group there was expression of Pax mRNA and protein in HKC cells. The expression of Pax mRNA and protein in HKC cells was positive in all the T groups, especially in T2 group and T3 group they were significantly increased compared with T1 group (P

Objective To investigate the expression of Paxillin (Pax) in human kidney proximal tubular epithelial cell line (HKC) induced by transforming growth factor ?1(TGF?1). Methods HKC cells cultured in vitro were divided into three groups at random: control group(C): cultured with free serum medium(FSM), TGF?1-treated groups (T1 and T2): cultured with FSM containing different concentrations of TGF?1 (T1: 5 ng/ml, T2: 10 ng/ml). After 48-hour treatment, the expression of Pax mRNA and protein was detected by reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemical staining in HKC cells respectively. Results In Group C, the expression of Pax mRNA and protein in HKC cells was elementary. However, in T1 and T2 groups , the expression of Pax mRNA and protein in HKC cells was greatly increased, especially in T2 group which was more significantly increased than T1 group (P

The origin, diameter, arrangement pattern, distribution and microvascular architecture of the intracerebral segments(IS) of the central branches of the middle cerebral artery(MCA) were examined and pictured in 27(10 infants, 5 newborns, 12 fetuses) unfixed brains under stereoscopic microscope and scanning electron microscope. 1. The extracerebral segments(ES) of the central branches run toward the anterior perforated substance in S-shaped curves. The IS arise from ES or their collateral branches. They form the fan-shaped appearance in rostromedial and caudolateral state after entering brain. 2. The IS give rise collateral branches in right or acute angles, and they are of two kinds: the longitudinal and the transverse branches. The mean diameter of the IS in original site is 0.21?0.18mm for the medial group; 0.36?1 0.21mm for the lateral group. 3. The medial group mainly distribute in the rostal part of the internal capsule and basal nucleus; the lateral group mainly distribute in the caudal part. 4. Some circular impressions of the precaillary sphincters were observed at the beginning of precapillary arteriole and capillary, converging point of tributary branches of venule. The relationship between the IS of the central branches and the hemodynamics was discussed.

OBJECTIVE: To improve the determination method of terbinafine hydrochloride by non-aqueous potentiometric titration.METHODS: Potentiometric titration was adopted to determine the content of terbinafine hydrochloride using glacial acetic acid as solvent,acetic anhydride instead of mercury acetate.Results of improved determination method were compared with that of primary method.RESULTS: One abrupt change was obtained in the titration curve.The repeatability precision RSD was lower than 0.15%.Results of improved determination method were compared with that of primary method with maximum deviation of 0.1%.CONCLUSION: Improved method not only discards mercuric salt but also obtain obvious abrupt change of titration curve.It is simple and rapid for the determination of terbinafine hydrochloride.

Hepatitis B virus (HBV)-induced liver failure is a severe clinical syndrome with complicated manifestations resulting in high mortality.The prognosis largely depends on early diagnosis and timely intervention.This article reviews the predictive and prognostic evalua-tion system for the development and progression of HBV-induced liver failure,so to improve the early diagnosis of this disease and the prog-nosis of patients.

OBJECTIVE:To explore the necessity of pharmaceutical care provided by clinical pharmacists during the use of ad-vertised drugs. METHODS:Through retrospectively analyzing drug advertisements permission number of which had been revoked issued by China Food and Drug Administration during Jan. 2013-Jun. 2015 statistically,the reasons for permission withdrawal were analyzed to put forward the focal point of pharmaceutical care development. RESULTS & CONCLUSIONS:A total of 46 items of permission number had been revoked,including 45 items of Chinese patent medicine (97.83%),1 item of western medicine (2.17%). The reasons for permission revoking mainly included overstating therapeutic efficacy without authorization,guaranteeing onset time,guaranteeing recovery in certain time,propagandizing drugs in the name of experts,etc. These drug advertisements sent relatively one-sided information so as to easily mislead patients and consumers to use drug irrationally. So,it is necessary to provide pharmaceutical care by clinical pharmacists about this kind of drug. The focal points of pharmaceutical care contain telling patients usage and dosage detailedly,and explaining possible ADR and relevant countermeasures;emphasizing different therapeutic efficacy,onset time and recovery time due to individual difference;strengthening prescription check and medication suitability ap-praisal,and so on.