1.Invasive Extramammary Paget Disease: A Report of 2 Cases with Immunohistochemical and Ultrastructural Findings.
Kyu Rae KIM ; Chong Woo YOU ; Jeong Ho HAN ; Young Hyeh KO
Korean Journal of Pathology 1996;30(9):858-864
We present 2 cases of invasive extramammary Paget disease occuring in the vulva area of a 60 year old female, and in the scrotal and penile area of a 63 year old male patient. The histologically typical Paget cells were not only seen in the surface epithelium but were also involved in the outer root sheath of the hair follicles. Stromal infiltration of tumor cells into the upper dermis were present in both cases, however, no underlying primary sweat gland carcinoma was present. Metastatic foci of inguinal lymph nodes showed apocrine-type epithelium with abundant eosinophilic granular cytoplasm, which were positive for anti-CEA and GCDFP-15, as well as eccrine-type epithelium containing mucinous secretory materials in the lumen and the cytoplasm. Ultrastructural findings showed interdigitating plasma membranes with prominent desmosomes between the Paget cells, intracytoplasmic tonofibrils, intracellular tubules, lipid vacuoles, and enlarged mitochondria. Histological, immunohistochemical, and ultrastructural findings suggested that Paget cells showed both eccrine and apocrine differentiation.
Female
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Male
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Humans
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Neoplasm Metastasis
2.Operative Treatment of Dorsolumbar Fractures and Fracture Dilocations: Clinical Experiences
Sang Lim KIM ; Keun Woo KIM ; Myung Ho KIM ; Han Suk KO ; Doo Young CHUNG
The Journal of the Korean Orthopaedic Association 1985;20(5):861-869
Since the introduction of Holdsworth's new classification on fracture-dislocations of spine with particular emphasis on the role of posterior ligmaent complex, operative reduction and spinal fusion is considered to be an established procedure in treating unstable injuries of the thoracolumbar spine.By stabilizing unstable fractures,nursing, and rehabilitation become much easier. Among the various methods and devices, Harrington instrumentation and posterior spinal fusion have been used and found to be acceptable in our series. Twenty five consecutive patients with unstable fractures and fracture-dislocations' of thoracolumbar spine were treated by open reduction and spinal fusion with Harrington rod fixation at the Department of Orthopedic Surgery, Kang Nam General Hospital Public Corporation from the period of 1982 to 1985. The following results were obtained from analysis of the cases. l. Among 25 cases, 15 (60%) were due to flexion-rotation violence, 5 pure flexion,3 vertical compression, 1 shear fracture respectively. 2. Among 16 cases with neurologic deficit, 15 cases showed considerabel improvement after surgery. 3. Most of the cases showed satisfactory bony fusion, and average postoperative kyphotic angle was 14.4 after 3 months. 4. Although no particular external fixation was adopted, permitting mobility in bed, postoperative correction was relatively well maintained.
Classification
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Hospitals, General
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Humans
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Neurologic Manifestations
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Orthopedics
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Rehabilitation
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Spinal Fusion
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Spine
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Violence
3.The Use of Ender Nails in Fractures of the Tibial Shaft
Keun Woo KIM ; Sang Lim KIM ; Han Suk KO ; Whan Jin OH ; Chong Wha PARK
The Journal of the Korean Orthopaedic Association 1986;21(2):281-287
Twenty one cases of adult tibial shaft fractures were fixed with flexible intramedullary nails at the Department of Orthopedic Surgery, Kang Nam General Hospital. The results are summerized as follows; l. Average healing time was 17 weeks. No case of nonunion was experienced. 2. As the operation was perfomed by closed method under fluoroscopic control, reduction of operation time is a major advantage. 3. Fixation was usually strong enough to allow immediate weightbearing and mobilization of the adjacent joints without external immobilization. 4. Three cases of delayed union and 2 cases of rotational malunion were experienced, but shortening and angulation were not so severe as to affect overall functional results. 5. In conclusion, Ender nailing is considered to be a valuable method in treating tibial shaft fractures. Even in cases with multiple injuries and in selected open cases, Ender nailing can be a saft procedure.
Adult
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Hospitals, General
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Humans
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Immobilization
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Joints
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Methods
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Multiple Trauma
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Orthopedics
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Tibial Fractures
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Weight-Bearing
4.Lateral Subtalar Dislocation of the Talus: A Case Report
Keun Woo KIM ; Sang Lim KIM ; Han Suk KO ; Suk Kee TAE ; Whan Jin OH
The Journal of the Korean Orthopaedic Association 1986;21(5):929-932
Dislocation involving talus is a rare injury comprising less than 1% of all dislocations of the joint. One case of lateral subtalar di location of the talus treated at the Department of Orthopedic Surgery, Kang Nam General Hospital in Decernber 1985. The patient was followed for 6 months and satisfactory healing was obtained.
Dislocations
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Hospitals, General
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Humans
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Joints
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Orthopedics
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Talus
5.Pathologic Separation of Capital Femoral Epiphysis due to an Osteosarcoma
Sang Lim KIM ; Keun Woo KIM ; Han Suk KO ; Suk Kee TAE ; Deog Ho KIM
The Journal of the Korean Orthopaedic Association 1987;22(4):993-995
In Korea, slipped capital femoral epiphysis is a rare disease. In which the capital femoral epiphysis migrate posteriorly and inferiorly against the neck portion. Sometimes it should be differentiated from other conditions that separate the femoral capital epiphysis. We have experienced a rare case of separation of capital femoral epiphysis due to an osteosarcoma in the proximal femoral metaphysis in the 15 years of old girl.
Epiphyses
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Female
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Humans
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Korea
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Neck
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Osteosarcoma
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Rare Diseases
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Slipped Capital Femoral Epiphyses
6.Hypochondroplasia: Report of A Case
Sang Lim KIM ; Keun Woo KIM ; Han Suk KO ; Suk Kee TAE ; Jong Taek OH
The Journal of the Korean Orthopaedic Association 1987;22(6):1379-1386
Hypochondroplasia is a form of short
Achondroplasia
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Christianity
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Dwarfism
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Extremities
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Hand
7.Arthrodesis of the Knee by AO Technique with Auto Compression Plate
Sang Lim KIM ; Keun Woo KIM ; Han Suk KO ; Suk Kee TAE ; Chong Wha PARK
The Journal of the Korean Orthopaedic Association 1987;22(6):1289-1296
Arthrodesis of the knes has lost its nopularity since the development of modern knee replscement arthroplasties, however it still has its place as a salvage procedure when replacement arthroplasties are contraindicated. Various techniques have been in the use including the time-tested Charnleys compressiori arthrodesis. Instead of using Charnley's and other similar compression devices, the authors applied single or double compression plates in 8 knees with severe destruction and deformities, and the results are summerized ss follows: l. Included in this series are 5 cases of tuberculous arthritis, 1 case of septic arthritis, 1 case of resistant scar contracture, and 1 case of Charcots knee. 2. Successful fusion was obtained within 18th week, aversge 13th week. No case of pseudarthrosis was experienced. 3. 3 cases of postop. wound drainage and 1 case of peroneal nerve palsy were experienced, but these did not compromise the final results. 4. It may be concluded that Arthrodesis of the knee using compression plate is rigid enough to permit early mobilization of patients and get the certainty of union.
Arthritis
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Arthritis, Infectious
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Arthrodesis
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Arthroplasty
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Arthroplasty, Replacement
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Cicatrix
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Congenital Abnormalities
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Contracture
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Drainage
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Early Ambulation
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Humans
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Knee
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Paralysis
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Peroneal Nerve
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Pseudarthrosis
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Wounds and Injuries
8.Clinical Significance of Ultrasonography for Detection of Hip Joint Effusion in Children: Analysis of the 23 Cases of Transient Synovitis of the Hip
Keun Woo KIM ; Han Suk KO ; Suk Kee TAE ; Dae Yeung KIM ; Lee Suk SEO
The Journal of the Korean Orthopaedic Association 1988;23(2):542-548
Transient synovitis of the hip in children is a non-specific inflammatory and self-limited condition. It is also the most common cause of painful hip in children under ten years of age. Despite of the benign prognosis, there are many difficulties in distinguishing it from other diseases of the hip joint. It remains a common diagnostic problem for clinician because the clinical symptoms, physical findings, and conventional radiography is not pathognomonic of the condition. The authors paid attention to the increase of effusion in the affected hip and studied the value of the hip ultrasonography in 24 cases of transient synovitis from August 1985 to July 1987. The results are summerized as follows : 1. The ratio of male to female was 7 to 1, average age was 7.9 yrs, average hospitalization period was 4.5 days. 2. In simple X-ray studies, no bony change was detectable except for soft tissue signs in 68% of the cases. 3. Capsule-to-bone distance in sagittal ultrasonographic section revealed abnormal increase in 87.5% of the affected hip. 4. Average capsule-to-bone distance of affected hip joint was 7.50 mm, while that of the normal hip was 4.26 mm. 5. As shown in the above studies, ultrasonography can be considered good noninvasive technique in detection and follow-up of hip effusion. So, it is thought to be a valuable method in the diagnosis of transient synovitis of the hip in children.
Child
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Diagnosis
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Female
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Follow-Up Studies
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Hip Joint
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Hip
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Hospitalization
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Humans
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Male
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Methods
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Prognosis
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Radiography
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Synovitis
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Ultrasonography
9.Clinical Analysis of 122 Trochanteric Fractures of Femur Treated by Flexible Intramedullary Nailing
Keun Woo KIM ; Sang Lim KIM ; Han Suk KO ; Suk Kee TAE ; Jong Taek OH
The Journal of the Korean Orthopaedic Association 1988;23(2):430-440
Closed intramedullary nailing for trochanteric fractures of femur has many advantages such as minimal operative trauma, low incidence of infection, good stability of fracture, low incidence of delayed or nounion and early ambulation. Complications have been frequently experienced especially in elderly, osteoporotic patients, but these could be avoided by meticulous surgical procedure. The authors hsve treated 99 cases of intertrochanteric fracture and 23 cases of subtrochanteric fracture from March 1982 to December 1987 with this method and the results are summerized as follows : 1. The aversge age was 61.4 yrs. 2. In classification of intertrochanteric fracture, stable fractures(Kyle type I & II) were 53 cases(43.3%) and unstable fractures(Kyle type III & IV) were 46 cases(37.6%). And in subtrochanteric fracture, stable transverse fractures were 12 cases(9.8%) and unstable long oblique or spiral fractures were 11 cases(9.0%). 3. Intraoperative complications were experienced in 23 cases(18.8%). The entry hole breakage was most common and occurred in 16 cases. 4. Of the 94 patients with more than 6 months follow-up, 21 patients(22.3%) showed more than one complication, e.g, knee joint pain in 15 cases, external rotation deformity in 8 and nail migration in 11 including 3 cases of fixation loss and one case of nonunion with nail breakage, etc. 5. Complications occurred more frequently in unstable fractures(31.8%) and in old ages (29.1%) than in stable fractures and in young ages respectively. And it was felt that complications could be minimized by packing of the medullary canal with nails. 6. It is thought that flexible intramedullary nailing is a good method for trochanteric fractures of femur not only in elderly debilitated patients but also in young patients. However, experience and caution are required to prevent complications.
Aged
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Classification
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Congenital Abnormalities
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Early Ambulation
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Femur
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Follow-Up Studies
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Fracture Fixation, Intramedullary
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Hip Fractures
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Humans
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Incidence
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Intraoperative Complications
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Knee Joint
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Methods
10.Isolation of Antimicrobial Substances from Hericium erinaceum.
Dong Myong KIM ; Chul Woo PYUN ; Han Gyu KO ; Won Mok PARK
Mycobiology 2000;28(1):33-38
Mycelium of Hericium erinaceum isolate KU-1 was cultured in liquid medium (HL medium) and solid medium (Ko medium) at pH 4.0 in 28degrees C. 1.0% glucose or fructose was the most favorable carbon source, and 0.2% amonium acetate or NaNO3 was an exellent nitrogen source for mycelial growth as well as production of antimicrobial substances. The mixture of saw dust 70% with rice bran 30% (SR medium) was the substrate for formation of sporophores. The active substrates in extracts from mycelium, culture filtrate and fruiting body were separated by TLC. The solvent for TLC was EtOAc: Chloroform: MeOH (10 : 5 : 10). Phenol-like substances appeared at Rf 0.5~0.9, and fatty acid-like substances appeared at Rf 0.1~0.2. The purified materials from the extracts showed antimicrobial effects to Escherichia coli, Bacillus subtilis, Staphylococcus aureus, Aspergillus niger, Candida albicans and Microsporum gypseum. The S. aureus was the most inhibited. Minimal inhibitory concentration (MIC) of purified white powder and the Hercenone derivatives against S. aureus were 5.65microg/ml and 1.85microg/ml, respectively.
Aspergillus niger
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Bacillus subtilis
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Candida albicans
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Carbon
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Chloroform
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Dust
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Escherichia coli
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Fructose
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Fruit
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Glucose
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Hydrogen-Ion Concentration
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Microsporum
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Mycelium
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Nitrogen
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Staphylococcus aureus