Dementia with Lewy bodies (DLB) usually presents with progressive cognitive decline and parkinsonism. We report a 68-year-old man who showed parkinsonism including resting tremor and mild cognitive decline. After anticholinergic medication, he showed recurrent visual hallucination. Neuropsychological tests revealed frontal and memory impairments. PET showed hypometabolism in the primary visual and visual association cortices. It is necessary to consider the possibility of DLB as well as anticholinergic side effect when visual hallucination occurs during the treatment of parkinsonism.
Aged ; Cholinergic Antagonists ; Dementia ; Hallucinations ; Humans ; Lewy Bodies ; Memory ; Neuropsychological Tests ; Parkinsonian Disorders ; Tremor

Relapse of herpes simplex virus (HSV) encephalitis rarely occurs after acyclovir treatment. We experienced a case of relapsing HSV encephalitis in the contralateral temporal lobe, resulting in Kluver-Bucy syndrome, after a full dose acyclovir treatment. Sudden behavioral and emotional changes after HSV encephalitis treatment suggest relapsing HSV encephalitis as well as temporal lobe epilepsy.
Acyclovir ; Encephalitis ; Encephalitis, Herpes Simplex ; Herpes Simplex ; Kluver-Bucy Syndrome ; Methylmethacrylates ; Polystyrenes ; Recurrence ; Simplexvirus ; Temporal Lobe

PURPOSE: In hemodynamically unstable patients, tissue perfusion is decreased and various means of continuous observation are required. However, prior methods for observing hemodynamic instability are invasive and/or difficult for continual observation. The present study evaluated the usefulness of the perfusion index (PI) in monitoring hemodynamically unstable patients in the emergency department. METHODS: From December, 2009 to April, 2010, patients admitted to our hospital emergency department with signs of hemodynamic instability were studied. Vital signs and stroke volume index (SVI) and cardiac index (CI) were measured, and PI was continuously monitored by a Radical-7 pulse oximeter (Masimo, USA). Each variable was measured 1 hour before and after treatment, and treatment methods included fluid therapy and vasoconstrictors, according to the patient condition. Status on changes and correlation between variables following treatment were confirmed through the Wilcoxon rank test and Spearman correlation test, respectively. The standard level of significance was p<0.05. RESULTS: Of the 26 patients, 19 were male (73.1%), with an average age of 68.54+/-14.32 years. Significant changes in each variable 1 hour before and after treatment were mean arterial pressure 53.51+/-8.29mmHg / 74.68+/-12.95 mmHg (p<0.001), SVI 26.70+/-14.04/34.27+/-13.56(p<0.001), CI 2.12+/-1.02/3.12+/-1.53(p<0.001), and PI 1.23+/-1.00/1.77+/-1.32(p<0.001). Variations of heart rate (R=-0.430, p=0.032) and SVI (R=0.432, p=0.031) were correlated to the variation of PI (dPI). CONCLUSION: PI may be useful in monitoring hemodynamically unstable patients in the ER.
Arterial Pressure ; Cardiac Output ; Emergencies ; Fluid Therapy ; Heart Rate ; Hemodynamics ; Humans ; Male ; Oximetry ; Perfusion ; Stroke Volume ; Vasoconstrictor Agents ; Vital Signs

PURPOSE: In hemodynamically unstable patients, tissue perfusion is decreased and various means of continuous observation are required. However, prior methods for observing hemodynamic instability are invasive and/or difficult for continual observation. The present study evaluated the usefulness of the perfusion index (PI) in monitoring hemodynamically unstable patients in the emergency department. METHODS: From December, 2009 to April, 2010, patients admitted to our hospital emergency department with signs of hemodynamic instability were studied. Vital signs and stroke volume index (SVI) and cardiac index (CI) were measured, and PI was continuously monitored by a Radical-7 pulse oximeter (Masimo, USA). Each variable was measured 1 hour before and after treatment, and treatment methods included fluid therapy and vasoconstrictors, according to the patient condition. Status on changes and correlation between variables following treatment were confirmed through the Wilcoxon rank test and Spearman correlation test, respectively. The standard level of significance was p<0.05. RESULTS: Of the 26 patients, 19 were male (73.1%), with an average age of 68.54+/-14.32 years. Significant changes in each variable 1 hour before and after treatment were mean arterial pressure 53.51+/-8.29mmHg / 74.68+/-12.95 mmHg (p<0.001), SVI 26.70+/-14.04/34.27+/-13.56(p<0.001), CI 2.12+/-1.02/3.12+/-1.53(p<0.001), and PI 1.23+/-1.00/1.77+/-1.32(p<0.001). Variations of heart rate (R=-0.430, p=0.032) and SVI (R=0.432, p=0.031) were correlated to the variation of PI (dPI). CONCLUSION: PI may be useful in monitoring hemodynamically unstable patients in the ER.
Arterial Pressure ; Cardiac Output ; Emergencies ; Fluid Therapy ; Heart Rate ; Hemodynamics ; Humans ; Male ; Oximetry ; Perfusion ; Stroke Volume ; Vasoconstrictor Agents ; Vital Signs

Heterotopic partial liver transplantation(HLT) in the rat is relatively simple method to orthotopic liver transplantation. Addition of mesocaval shunt which diverts almost intestinal blood to systemic circulation provides only splenopancreaticoduodenal blood for the graft. The usefulness of our novel model is first, evaluating the pure effect of pancreaticoduodenal blood to liver regeneration, second, evaluating the contribution of splanchnic viscera to liver reperfusion injury. In the first group (conventional HLT, C-HLT), the thirty percent graft liver was transplanted just below the host liver with whole portal blood input. In the second group(mesocaval shunt added HLT, M-HLT), the superior mesenteric vein was diverted to systemic circulation and portal blood from the spleen-pancreas-duodenum supplied the graft. The graft weight at 2 posttransplant weeks was significantly increased in the C-HLT group compared with the M-HLT group, which suggests pancreatic blood alone is not sufficient to regenerate the partial liver grafts. There was no significant difference in the graft survival between two groups, which implies the influence of intestine to postreperfusion injury is negligible.
Animals ; Graft Survival ; Intestines ; Liver Regeneration ; Liver Transplantation* ; Liver* ; Mesenteric Veins ; Models, Animal* ; Rats* ; Reperfusion Injury ; Transplants ; Viscera

PURPOSE: The treatment of choice for gastric submucosal tumors (SMT) is surgical resection. Recent advanced techniques has facilitated more extensive application of laparoscopic surgery to most types of resectable gastric SMTs. The aim of this study was to verify the efficacy of laparoscopic resection for treatment of gastric SMT through analysis of outcomes obtained at a single center. METHODS: A total of 141 patients who underwent laparoscopic resection for treatment of gastric SMT were enrolled between April 2003 and June 2011. Analysis of the demographics, tumor characteristics, and surgical or oncological outcomes of these patients was performed. RESULTS: Gastrointestinal stromal tumors (GIST) were the most common pathologic findings (90 cases), and the upper third of the stomach was the most common location (70 cases). Wedge resections were performed in 128 patients and major gastrectomies were performed in 13 patients. The mean surgical time was 102 minutes, which was reduced to a stable 70 minutes after the 30th case. The surgical time for tumors located on the posterior or lesser portion of the upper third of the stomach was longer than that for other lesions. Twelve postoperative complications, including two cases of intra-abdominal bleeding, one case of marginal ulcer bleeding, and one case of leakage occurred. However, there was no occurrence of complications after the 70th case. During the follow-up period, two patients suffered recurrent GIST. CONCLUSION: Laparoscopic surgery for treatment of gastric SMT is safe and feasible, particularly as the surgeon develops greater skill with increased experience. Laparoscopic resection is useful for treatment of any type of gastric SMT.
Demography ; Follow-Up Studies ; Gastrectomy ; Gastrointestinal Stromal Tumors ; Hemorrhage ; Humans ; Laparoscopy ; Operative Time ; Peptic Ulcer ; Postoperative Complications ; Stomach ; Stomach Neoplasms

Objectives: To investigate the effect of nicotine on the healing of an oral cavity wound, high and low concentrations of nicotine were administered on human gingival fibroblasts. Methods: Nicotine at concentrations of 0.1, 1, 5, and 10 mM were administered to gingival fibroblasts to evaluate the survival capability of the cells. Nicotine at 0.1 mM, a nonapoptotic concentration, was administered to evaluate apoptosis using Annexin V-FITC/Propidium Iodide cell staining.Nicotine at 1, 10, and 100 mM were administered to measure the expression of inflammatory cytokines, which was measured by RT-PCR and ELISA. FGF was treated with an additional 1, 10, or 100 mM of nicotine to evaluate cell proliferation and wound healing. Results: As the concentration of nicotine increased (0.1, 1, 5, and 10 mM), the survival capability of the cells reduced. When cells were exposed to low nicotine concentration (0.1 mM) for 24 h, apoptosis occurred. Moreover, if the cell was exposed for 48 h, cell apoptosis occurred with necrosis. As the concentration of nicotine increased (1, 10, and 100 mM), more inflammatory cytokines were expressed. When EC LPS and TF LPS were combined with a low concentration of nicotine (1 and 10 mM), the expression of inflammatory cytokines was suppressed. The FGF level decreased as the nicotine concentration increased (1, 10, and 100 mM). Conclusions Nicotine interferes with the wound healing process of gingival fibroblasts. To maintain the wound healing process after a surgery or dental procedure, cessation of smoking is recommended.

PURPOSE: Laparoscopic assisted distal gastrectomy (LADG) has been increasingly used for the treatment of early gastric cancer. However, there have been few studies on the learning curve (LC) for this procedure. The aim of this study was to determine the time needed to overcome the LC of LADG and to document the surgical and clinical differences. METHODS: This study retrospectively reviewed 202 LADGs performed by a single surgeon. The time required to overcome the LC was determined by examining the operation times. The surgical results, preoperative and postoperative clinicopathology data between before and after overcoming the LC were compared. In addition, the point of overcoming the LC was determined according to the occurrence of major complications. RESULTS: The 63rd case was identified as the point when the LC had been overcome according to the operation time, and the differences between before and after overcoming the LC with regard to the operative time (250 vs 156 minutes), transfusion rate (30 vs 2.8%), proximal and distal safety margin from the lesion (4.3 vs 5.9 and 4.3 vs 6.9 cm), the total number of dissected lymph nodes (20.6 vs 34.2), white blood cell count checked at the postoperative 2nd day (12,377 vs 9,567/mm3), hospital stay (10.8 vs 7.9 days) and the rate of major complications (6 vs 1%) were all significant (all P<0.05). The point when the LC was overcome according to the occurrence of major complications occurred at the 50th case. CONCLUSION: Overcoming the LC of LADG has benefits in terms of the patient's safety and surgeon's stress.
Gastrectomy* ; Laparoscopy ; Learning Curve* ; Learning* ; Length of Stay ; Leukocyte Count ; Lymph Nodes ; Operative Time ; Retrospective Studies ; Stomach Neoplasms*

The prevalence of colon cancer is increasing in Korea and the principal strategy of its management is early detection and surgical resection. For the early detection of colon cancer, endoscopic evaluation is important and the ability to find out early stage small lesion is needed for the endoscopist. To find out encloscopic features of early colon cancer, we reviewed 17 cases of early colon cancer who have admitted to Seoul National University Hospital from January 1982 to December 1993. 1)59% of the lesions were located in rectum and the size ranged from 0.7cm to 9cm, all of the 17 cases showed polypoid mass contour and the surface of them had erosion, hyperemia, ulceration and easy touch bleeding tendency. 2) Colon cancer was diagnosed by endoscopic gross findings in 41% and endoscopic biopsy could confirm colon cancer in 70%. However, barium enema could diagnose only 41% of early colon cancer. 3) Five cases were operated under the diagnosis of colonic adenoma which were large(>3 cm) villous type or contained severe dysplasia 4) Submucosal tumor infiltration was found in 10 cases and 65% had associated adenoma 5) Lymph node involvement was none and there was no recurrence in 47 month follow up period after various surgical treatments.
Adenoma ; Barium ; Biopsy ; Colon* ; Colonic Neoplasms* ; Diagnosis ; Endoscopy ; Enema ; Follow-Up Studies ; Hemorrhage ; Hyperemia ; Korea ; Lymph Nodes ; Prevalence ; Rectum ; Recurrence ; Seoul ; Ulcer

PURPOSE: Body fluid status of patients in an emergency room environment is a very important parameter during clinical evaluation. In this study, we wanted to know the relationship between the diameter of the inferior vena cava and the diameter of the (IVC/Ao index) and central venous pressure (CVP) in hemodynamically unstable patients. METHODS: This study was done prospectively in an emergency medical center of a hospital from January to August, 2009. We compared the diameter of the IVC, the diameter of inferior vena cava/the body surface area index (IVC/BSA index), the IVC/Ao index, and other variables. Before and after hydration of patients with a systolic blood pressure less than 90 mmHg and who had a central venous catheter in place. Then, we calculated the correlation coefficient for DeltaCVP, DeltaIVC/Ao index, and other indexes. RESULTS: Fifty-nine patients were enrolled in the study. The mean IVC diameter before hydration was 14.3+/-2.7 mm; it was 15.6+/-2.7 mm after hydration (p<0.01). The IVC/BSA index before hydration was 8.75+/-1.72 and 9.55+/-1.79 after hydration (p<0.01). The IVC/Ao index before hydration was 1.08+/-0.23; it was 1.16+/-0.25 after hydration (p<0.01). The correlation coefficient for DeltaCVP and DeltaIVC was 0.37 (p<0.01); for DeltaCVP vs. the DeltaIVC/BSA index it was 0.37 (p<0.01); for the DeltaIVC/Ao index it was 0.27 (p=0.04). CONCLUSION: CVP has a higher correlation to IVC diameter and to IVC/BSA index than to the IVC/Ao index. Hence, we should estimate the IVC/Ao index and use that estimate along with other indexes to evaluate body fluid status when dealing with hemodynamically unstable patients.
Blood Pressure ; Body Fluids ; Body Surface Area ; Central Venous Catheters ; Central Venous Pressure ; Emergencies ; Humans ; Hypogonadism ; Mitochondrial Diseases ; Ophthalmoplegia ; Prospective Studies ; Vena Cava, Inferior