1.The pathogenic mechanisms of motor weakness following aneurysmal subarachnoid hemorrhage: A review
Neurology Asia 2017;22(3):185-191
Motor weakness is one of the neurological complication that can occur after aneurysmal subarachnoid
hemorrhage (SAH); incidence of motor weakness of 14~29% has been reported. Detailed information
on the pathogenic mechanism of motor weakness is essential for brain rehabilitation because it enables
estimation of the severity of injury, establishment of scientific rehabilitative strategies, and prediction
of motor outcomes by clinicians. However, the exact pathogenic mechanisms of motor weakness
following aneurysmal SAH have not been clearly elucidated. In this article, 14 previous studies on
pathogenic mechanisms in patients with aneurysmal SAH were reviewed according to the location of
the lesion (cerebral cortex, brainstem, spinal cord, and peripheral nerve). The following pathogenic
mechanisms have been suggested: vasospasm, cerebral ischemia, hydrocephalus, compression of
cerebral cortex, neural injury, spinal cord infarction, and radiculo-neuropathy. Considering the high
incidence of aneurysmal SAH and motor weakness following aneurysmal SAH, we believe that the
pathogenic mechanisms of motor weakness have been relatively understudied. More effort should be
taken to investigate this important topic.
Subarachnoid Hemorrhage
2.A Clinical Study on Pathologic Fractures
Han Koo LEE ; Jang Seok CHOI ; Sang Chul SUNG
The Journal of the Korean Orthopaedic Association 1977;12(3):439-445
Pathologic fracture occurs in a bone with preexisting stuctual weakness. The author reviewed 30 cases of pathologic fractures in which admission record and X-ray finding was well preserved among 53 cases admitted patients in the department of Orthopaedic Surgery, Seoul National Universty Hospital for 10 years from 1967. The results were as follows: 1.Age & Sex incidence showed even distribution. 2. The most frequent involved site was femur (40%) 3. The underlying etiology was as follows: 2 chronic osteomyelitis 1 homophilia 7 benign tumor 20 malignant tumor 4. metastatic tumor was the most frequent cause in 30 cases. 5. Treatment was as follows: Conservative treatment 4 cases Surgery 21 cases.
Clinical Study
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Femur
;
Fractures, Spontaneous
;
Humans
;
Incidence
;
Osteomyelitis
;
Seoul
3.Fatty Acids Composition in Breast Milk and Its Relationship with Infant Body Weight Gain.
Yu Sok HAN ; Mi Jung PARK ; Sung Han KIM ; Jang Hyuk AHN ; Hyun Sok JIN
Journal of Korean Society of Pediatric Endocrinology 2004;9(2):173-178
PURPOSE:Recent studies proposed that polyunsaturated fatty acids (PUFA) of the omega6 series (linoleic acid, LA) compared to the omega 3 series (linolenic acid, LNA) may be a potent promoters of adipogenesis during the gestation/lactation period. Increased ratio of LA/LNA may stimulate adipose tissue development during gestation/lactation period and may subsequently lead to chilhood obesity. The purpose of this study is to evaluate fatty acids composition of the breast milk in Korean lactating women and to analyze the relationship between LA/LNA and the body weight gain of the infants. METHODS:Fifty eight healthy postpartum lactating women and their healthy 58 breast feeding infants were studied. At 11.3+/-3.9 days of postpartum, breast milk were taken and analyzed by gas-liquid chromatography with one-step methylation method. RESULTS:The total fat contents in breast milk were 3.2+/-1.3%. The total fat contents in breast milk were not related to maternal BMI or Kaup index of infants. The percentage of PUFA was 24.9+/-6.0%. Among these PUFA, the percentage of LA and LNA was 20.3+/-5.8% and 2.2+/-0.8%, respectively. LA/ LNA ratio was 10.2+/-2.5. There were no significant correlations between LA/LNA ratio and infant weight gain during the first 2 months of life. CONCLUSION: Short term weight gain of infant was not related to the LA/LNA ratio in the breast milk. Further studies on the long term effects on fat percent and body weight of infants would be needed.
Adipogenesis
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Adipose Tissue
;
alpha-Linolenic Acid
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Body Weight*
;
Breast Feeding
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Breast*
;
Chromatography, Gas
;
Fatty Acids*
;
Fatty Acids, Unsaturated
;
Female
;
Humans
;
Infant*
;
Linoleic Acid
;
Methylation
;
Milk, Human*
;
Obesity
;
Postpartum Period
;
Weight Gain
4.A Comparative Study of the Toxicity Between carboplatin and Cisplatin in VBP Combination Chemotherapy.
Pan Young KIM ; Hee Sung SEO ; Jung Ok SHIN ; Kyung Taeck JANG ; Dong Han BAE
Korean Journal of Gynecologic Oncology and Colposcopy 1996;7(3):189-198
Cisplatin has been widely used as chemotherapeutic agent for the treatment of cervical cancer, ovarian cancer, head and neck cancer and squamous cell carcinoma of lung. But cisplatin is highly toxic with nephrotoxicity, gastrointestinal toxicity, myelosuppression and neurotoxicity. The second generation drug of platinum compound, carboplatin was developed in 1980s to reduce side effects. Carboplatin has low nephrotoxicity but its major toxic effect is thrombocytopenia, In this study, the side effects of cisplatin and carboplatin were evaluated on 37 patients of cervical cancer in 169 chemotherpy cycles who were recieved combined VBP chemotherpeutic regimen consisting of cisplatin or carboplatin. Nephrotoxicity of grade 2 or over were 16% in cisplatin group and 1% in carboplatin group. Granulocytopenia of grade 2 or over were 34% in cisplatin group and 10% in carboplatin group. Thrombocytopenia of grade 2 or over were 7% in cisplatin group and 21% in carboplatin group. Gastrointestinal toxicity of grade 2 or over were 11% in cisplatin group and 0% in carboplatin group. This clinical study demonstrated that cisplatin has more toxic effects than carboplatin except thrombocytopenia.
Agranulocytosis
;
Carboplatin*
;
Carcinoma, Squamous Cell
;
Cisplatin*
;
Drug Therapy, Combination*
;
Head and Neck Neoplasms
;
Humans
;
Lung
;
Ovarian Neoplasms
;
Platinum
;
Thrombocytopenia
;
Uterine Cervical Neoplasms
5.Reappraisal and Practical Application of International League Against Epilepsy ( ILAE 1989 ) Classification of Localization-Related Epilepsies in Adult.
Jae Hong HAN ; Jang Sung KIM ; Youn Min OH
Journal of the Korean Neurological Association 1999;17(5):637-644
BACKGROUND: Since 1985 when ILAE proposed its first classification system of epilepsy, many studies have reported the practical applicability of the system. However, its limitations have been elucidated. In order to find out the applicability and limitations of the ILAE classification system and the role that diagnostic parameters (semiology, EEG and MRI) take in the anatomical localization of localization-related epilepsies (LREs), we investigated the clinical data of adult patients with LRE in step-wise way. METHOD: We recruited 173 patients with newly-referred/diagnosed LRE from our departmental data registry. Idiopathic epilepsies were excluded. We evaluated the anatomical localization rate(LR) according to each diagnostic parameter, the concordant localization rate(CLR) between two parameters and between three parameters. LR in total patients by any one of three diagnostic parameters was also evaluated. MRI abnormalities were evaluated in those patients showing concordant localization between semiology and EEG. RESULTS: The highest anatomical LR(67.1%) was reported in the semiological parameter. CLR between semiology and EEG was 28.9%. CLR between three parameters was 16.2%. MRI abnormalities were seen in 60% of patients with concordant localization between semiology and EEG. Fifty six percent of electroclinically concordant patients showed concordant localization with an MRI and 79% of them were concordantly localized in the temporal lobe. The LR in total patients was 71.7%. In each of the evaluation steps, the temporal lobe LR was the highest. CONCLUSIONS: Total lobar LR by any one diagnostic parameter in all the patients was high according to the ILAE diagnostic criteria. Semiology was the best localizing parameter, however, combined evaluation with either EEG or MRI reduced the localizability. Even though the MRI study showed a significant discordance rate in patients with electroclinical localizations, it could identify the underlying etiology in a major proportion of the patients. This study showed the importance of an imaging study in the lobar localization of LREs combined with an electroclinical localization by the ILAE classification system.
Adult*
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Classification*
;
Electroencephalography
;
Epilepsies, Partial*
;
Epilepsy*
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Humans
;
Magnetic Resonance Imaging
;
Temporal Lobe
6.Right Thalamic Hemorrhage Resulting from Low-voltage Electrical Injury: A Case Report.
Journal of the Korean Society of Emergency Medicine 2012;23(4):555-558
We report on a case of right thalamic hemorrhage resulting from low-voltage electrical injury caused by contact between a wet hand and an electronic scale. The patient was treated with clopidogrel for control of a previous cerebral infarction. The patient complained of numbness of the left upper extremity. On neurological examination, decreased motor power of her left side, grade IV, was observed. Findings on computerized tomography of the brain revealed a right thalamic hemorrhage. To the best of our knowledge, cerebral hemorrhage resulting from low-voltage electrical injury has not been previously reported in the literature.
Brain
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Cerebral Hemorrhage
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Cerebral Infarction
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Electric Injuries
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Electronics
;
Electrons
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Hand
;
Hemorrhage
;
Humans
;
Hypesthesia
;
Neurologic Examination
;
Ticlopidine
;
Upper Extremity
7.A case of thanatophoric dysplasia.
Tae Wook SONG ; Sang Chul HAN ; Jang Hyun NAM ; Keun Young LEE ; Sung Won KANG
Korean Journal of Obstetrics and Gynecology 1992;35(5):765-773
No abstract available.
Thanatophoric Dysplasia*
8.Bilateral temporo-mandibular joint dislocation due to complication of oro-facial dyskinesia
Sung Ho Jang ; Ah Young Lee ; Byung Rho Chin ; Han Do Lee
Neurology Asia 2016;21(3):291-293
Oro-facial dyskinesia (OFD) is involuntary, abnormal, uncontrolled and stereotyped movements,
consisting of forehead furrowing, eye opening and closing, smacking and pursing of the lips, lateral
deviation and protrusion of the tongue, and occasionally lateral deviation and protrusion of the jaw.1
OFD is known to have various complications including speech difficulty, chewing and eating disorders,
and social embarrassment; facial muscle stiffness, mucosal and gingival traumatic lesions. In addition,
it may leads to cranio-mandibular joint (TMJ) complications in the presence of intense and prolonged
abnormal movements, with pain and degeneration.1,2 There is no previous report of TMJ dislocation
due to OFD. In this report, we describe a patient who developed bilateral anterior TMJ dislocation
due to OFD which occurred following intra-cranial hemorrhage (ICH).
Movement Disorders
;
Dyskinesias
9.Correction of Prominent Axillary Lump through Incision Along Axillary Wrinkle Line.
Se In JANG ; Min Sung SEO ; Ghil Hyun HAN ; Young Soo KIM
Journal of the Korean Society of Aesthetic Plastic Surgery 2001;7(2):158-161
No abstract available.
10.Computed tomographic evaluation of cerebral disorder in pediatric population
Jang Sik LEE ; Sang Il SUH ; Jeong Dong JEON ; Chang Yul HAN ; Soo Sung PARK
Journal of the Korean Radiological Society 1983;19(4):681-687
A total of 110 computed tomographic scans of the brain in pediatric population were reviewed. They wereretrospectively analyzed focusing on the ventricular dilatation, widening of subdural space in frontal region andprominence of cerebral sulci in hemisphere. The results were compared with clinical recored. In the measurementbicaudate ventricular index waas above 0.18, which ws considered ventricular dilatation. The subdural space in thefrontal region and teh prominent cerbral sulci in the hemisphere were visualized among the cases aged over twoyears with clinical evidence of cerbral problem is pediatric population. The diagnostic application of CT to thecases of cerebral disorder in pediatric population is highly recommended.
Brain
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Dilatation
;
Subdural Space