No abstract available.

A total of 110 computed tomographic scans of the brain in pediatric population were reviewed. They wereretrospectively analyzed focusing on the ventricular dilatation, widening of subdural space in frontal region andprominence of cerebral sulci in hemisphere. The results were compared with clinical recored. In the measurementbicaudate ventricular index waas above 0.18, which ws considered ventricular dilatation. The subdural space in thefrontal region and teh prominent cerbral sulci in the hemisphere were visualized among the cases aged over twoyears with clinical evidence of cerbral problem is pediatric population. The diagnostic application of CT to thecases of cerebral disorder in pediatric population is highly recommended.
Brain ; Dilatation ; Subdural Space

No abstract available.
Craniocerebral Trauma* ; Disseminated Intravascular Coagulation* ; Head* ; Humans ; Latex*

It is essential to define the accurate location and extent of tumors for the treatment planning and evaluation of the prognosis of the musculoskeletal tumors. Since Magnetic Resonance Imaging(MRI) provides excellent tissue contrast and multiplsnar image. MRI could be applied to the diagnosis and the treatment planning of musculo-skeletal tumors. Thirty-one patients with bone and soft tissue tumors underwent MRI at Department of Orthopedic Surgery, Seoul National University Hospital, since Jun. 1986, and the applicability of MRI in treatment planning of bone and soft tissue tumors was evaluated. Multiplanar image and excellent tissue contrast between soft tissue made it possible to define the location and the extent of tumor accurately. Tl weighted image was advantageous in intramedullary tumor extent, while T2 weighted image was helpful in soft tissue invasion. It was possible to guess histologic diagnosis of tumor in such cases as hemangioma, aneurysmal bone cyst, lipoma, and desmoid tumor. Above advantages guided the treatment planning and determination of biopsy site. Especially in two cases of osteosarcoma, which were highly malignant, limb salvage operation was performed instead of amputation.
Amputation ; Aneurysm ; Biopsy ; Bone Cysts ; Diagnosis ; Fibromatosis, Aggressive ; Hemangioma ; Humans ; Limb Salvage ; Lipoma ; Magnetic Resonance Imaging ; Orthopedics ; Osteosarcoma ; Prognosis ; Seoul

No abstract available.
Bone Marrow*

OBJECTIVE: Ovarian cancer is a silent disease with few symptoms. Because early detection of ovarian cancer is difficult, most cases are diagnosed at an advanced stage. To determine whether an ovarian tumor is malignant or not, various diagnostic procedures have been used including physical examination, ultrasound and tumor markers such as CA-125. We recently compared color Doppler sonography(CDS) with the morphological scoring system and CA-125 levels in establishing an accurate preoperative diagnosis of adnexal mass. As a result, we tried to compare the morphological scoring system with CA-125 and CDS in the diagnosis of adnexal mass. METHODS: The medical records of 47 patients referred with preexisting adnexal lesion were reviewed retrospectively by comparing ultrasonic data(morphological scoring system and color Doppler finding) with serum CA-125 and MRI findings. RESULTS: Forty-nine masses were removed surgically and confirmed as 25 malignancies and 22 benign tumors. In cases using the morphological scoring system and CA-125, the accuracy showed 95% sensitivity. In cases using the morphological scoring system and CDS, the sensitivity was 88%. In cases using the morphological scoring system and CDS, the sensitivity was 48%. CONCLUSIONS: The morphological scoring system and CA-125 are the basic methods for predicting ovarian malignancy. MRI and CDS may be also useful diagnosis methods in diagnosis of ovarian malignancy. But combination of these diagnositic modalities may not improve the accuracy of predicting ovarian malignancy, significantly.
Diagnosis ; Humans ; Magnetic Resonance Imaging ; Medical Records ; Ovarian Neoplasms ; Physical Examination ; Retrospective Studies ; Biomarkers, Tumor ; Ultrasonics ; Ultrasonography*

Kallmann's syndrome is characterized by hypogonadotrophic hypogonadism resulting from insufficient release of GnRH and associated with anosmia or hyposmia, which has been related to agenesis of olfactory bulbs. We experienced a case of 17 year-old Kallmann's syndrome woman and a case of successful pregnancy of 29 year-old Kallmann's syndrome woman with hMG and hCG treatment and present two cases with a review of literatures.
Adolescent ; Adult ; Female ; Gonadotropin-Releasing Hormone ; Humans ; Hypogonadism ; Kallmann Syndrome* ; Olfaction Disorders ; Olfactory Bulb ; Pregnancy*

No abstract available.
Anemia* ; Erythropoietin* ; Humans*

No abstract available.

In this study the effect of insulin and aminoguanidine on the expression of iNOS and the development of insulitis in the multiple low dose streptozotocin (SZ) induced diabetic (LDSD) mice was evaluated. Eighty mice (Charles-River CD-1 mice) were divided into four groups. Group I received SZ for five days. Group II received SZ for five days and was followed by insulin treatment. Group III received SZ for five days and was followed by aminoguanidine treatment. Group IV was normal control group. The blood glucose level and body weight were measured weekly. On the 35th day, pancreat ic sections were observed to evaluate the frequency and the severity of insulitis in addition to the immunohistochemical expression of iNOS in the pancreatic islets. Blood glucose levels of group IV were significantly lower than other experimental groups on the 21st, 28th, and 35th day. The difference in blood glucose levels was not statistically significant. Incidence of the insulitis was lower in group II than in groups I and III. The severity of insulitis correlated with the increase in blood glucose level only in group II. The expression of iNOS was more pronounced in group I than in groups II and III. Aminoguanidine did not inhibit development of the insulitis but decreased expression of iNOS in the pancreatic islets. Therefore it is speculated that iNOS production is one of the factors and other pathogenetic mechanisms might be involved in the development of insulitis.
Animals ; Blood Glucose ; Body Weight ; Incidence ; Insulin* ; Islets of Langerhans ; Mice* ; Nitric Oxide Synthase Type II* ; Streptozocin