1.The Effect of Spacer on the Bronchodilator Response in the First Medical Examination of Old Age.
Yang Deok LEE ; Sung Kyun SIN ; Yong Seon CHO ; Min Soo HAN
Journal of the Korean Geriatrics Society 2004;8(4):228-232
BACKGROUNDS: When measuring lung function and response to bronchodilator, MDI(metered-dose inhaler) is commonly used but unfamiliarity of its use and cold sensation by the puffed gas decrease reliability of the result. Spacer can reduce the cold freon effect and undesired oropharyngeal deposition caused by the rapid evaporation of the propellant and there are many studies which showed more effectiveness of spacer on the treatment of children with asthma but no study whether it is effective on the bronchodilator response test in the first medical examination of old age. Therefore, we tested whether the use of spacer can reduce the cold freon effect and improve the bronchodilator response in the first medical examination of old age. METHODS: Two hundred of elderly patients( 65years) who had never used MDI were measured the bronchodilator response. Subjects were randomised to either spacer-user or spacer-nonuser. Twenty minutes after 400 g fenoterol was administered, FEV1 (forced expiratory volume in one second) was measured. Bronchoconstriction was defined as a decrease in FEV1 by 10% or greater after bronchodilator inhalation. We further devided each group into normal or obstructive group, obstructive group was defined as FEV1<80% of predicted and FEV1/FVC<70%. RESULTS: In normal group, spacer-user(n=83) showed greater bronchodilator response than spacer-nonuser(n=66), 6.43% vs 3.81% respectively(p<0.05) and two case of bronchoconstriction occured only in spacer-nonuser. In obstructive group, there is no significant difference in bronchodilator response between spacer-user(n=18) and spacer-nonuser(n=33), 12.32% vs 11.16% respectively(p>0.05) but brochoconstriction(n=1) occured only in spacer-nonuser. CONCLUSION: Spacer improved bronchodilator response and prevented bronchoconstriction, in the first medical examination of old age.
Aged
;
Asthma
;
Bronchoconstriction
;
Child
;
Chlorofluorocarbons
;
Fenoterol
;
Humans
;
Inhalation
;
Lung
;
Sensation
2.An Analysis on Factors Relating to Fiscal Deficit for Regional Health Insurance Program in Korea.
Han Joong KIM ; Woo Hyun CHO ; Sun Hee LEE ; Hyung Kon KANG ; Yang Kyun KIM
Korean Journal of Preventive Medicine 1992;25(4):399-412
This study was designed to investigate factors relating to fiscal deficit for regional health insurance. The financial statements for the fiscal year 1990 of nationwide 254 regional medical insurance societies were analyzed. Important findings are summarized below: 1. There were differences in the main reason for the financial deficit among regions when deficit and surplus societies were compared by regions. The total revenue per enrollee, especially revenue from the premium contribution of a deficit society was significantly smaller than that of a surplus society in large cities and counties. On the other hand, the total expenditure per enrollee of a deficit society was larger than that of a surplus society in small cities. 2. Both low premium irate at the beginning of health insurance program and less effort to increase the premium rate were main factors for the smaller revenue from the contribution of a deficit society in large cities and counties. 3. Larger expenditures per covered person of a deficit society in small cities were explained with larger medical expenditures especially for out-patients services rather than larger administrative expenses. 4. A regression analysis showed that utilization rates in out-patient services were significantly associated with income and numbers of total medical care institution per capita within a region where a health insurance society located. Also expenses paid by insurer per visit were associated with the proportion of utilization for tertiary care hospitals as well as the proportion of utilization of public health centers.
Hand
;
Health Expenditures
;
Humans
;
Insurance
;
Insurance Carriers
;
Insurance, Health*
;
Korea*
;
Outpatients
;
Public Health
;
Tertiary Healthcare
3.Erratum: Development of R packages: ‘NonCompart’ and ‘ncar’ for noncompartmental analysis (NCA)
Hyungsub KIM ; Sungpil HAN ; Yong Soon CHO ; Seok Kyu YOON ; Kyun Seop BAE
Translational and Clinical Pharmacology 2018;26(3):141-141
There are some errors in the published article. The authors would like to make corrections in the original version of the article.
4.Coronary Flow Doppler Profile in No-Reflex Phenomenon after Direct PTCA in Acute Myocardial Infarction.
Han Soo KIM ; Yun Kyung CHO ; Won KIM ; Suk Kyun SHIN ; Joon Han SHIN ; Seung Jea TAHK ; Byung Il CHOI
Korean Circulation Journal 1996;26(1):124-129
Profound reduction of anterograde coronary flow with concomitant ischemia is seen occasionally during percutaneous coronary intervention despite technically successful procedure. We found interesting coronary flow pattern in a patient with acute myocardial infarction, showing angiographic no reflow phenomenon after direct PTCA. The coronary blood flow pattern of the angiographic no-reflow phenomenon in this case was characterized by minimal systolic flow and sharp deceleration of diastolic flow. Coronary flow reserve calculated by the ratio of adenosine induced maximal hyperemic velocity and basal velocity was reduced. The Dopplertipped guide wire was useful for observation of phasic coronary flow pattern of angiographic no-reflow phenomenon.
Adenosine
;
Deceleration
;
Humans
;
Ischemia
;
Myocardial Infarction*
;
No-Reflow Phenomenon
;
Percutaneous Coronary Intervention
5.Elevated Aurora Kinase A Protein Expression in Diabetic Skin Tissue.
Moon Kyun CHO ; Je Min AN ; Chul Han KIM ; Sang Gue KANG
Archives of Plastic Surgery 2014;41(1):35-39
BACKGROUND: Aurora kinase A (Aurora-A) plays an important role in the regulation of mitosis and cytokinesis. Dysregulated Aurora-A leads to mitotic faults and results in pathological conditions. No studies on Aurora-A expression in human diabetic skin tissue have been reported. In light of this, we explored the expression of Aurora-A in human diabetic skin tissue. METHODS: Aurora-A protein was evaluated by western blotting in 6 human diabetic skin tissue and 6 normal skin specimens. RESULTS: Increased expression of Aurora-A protein was detected in all diabetic skin tissue samples in both western blot analysis and immunohistochemical staining. However, in the case of the normal skin tissue, no bands of Aurora-A protein were detected in either the western blotting analysis or the immunohistochemical staining. CONCLUSIONS: Thus far, there have been no studies on the expression of Aurora-A in diabetic skin tissue. However, we believe that oxidative DNA damage related to the expression of Aurora-A protein and Aurora-A could be involved inhuman diabetic skin tissue.
Aurora Kinase A*
;
Blotting, Western
;
Cytokinesis
;
Diabetes Mellitus
;
DNA Damage
;
Humans
;
Mitosis
;
Skin*
6.A Study on Evolution of Lipoprotein(a) in Newborns.
Keun Haeng CHO ; Young Sook HONG ; Joo Won LEE ; Soon Kyun KIM ; Young Chang TOCKGO ; Han Kyeom LIM
Journal of the Korean Pediatric Society 1994;37(8):1078-1091
Lipoprotein(a) [Lp(a)] is considered an additional, independent and largely genetically determined risk factor for the development of premature coronary heart disease. Furthermore abnormal plasma lipoprotein patterns have been associated with increased risk for developing coronary heart disease. Among these lipoproteins, an increased concentration of serum Apo B and decreased level of Apo A are considered as major risk factors. together with elevated serum cholesterol and decreased HDL cholesterol. The aim of this study is to assess serum Lp(a) levels in newborns and to observe their evolution between brith, 7 days and 1 month in 64 healthy newborns by using ELISA method, Other lipid profiles were also measured and compared with feeding formula methods. The results obtained were as follows: 1) There were no significant changes from birth to 7 days, but was increased significantly after 7 days to 1 month of serum Lp(a) concentrations. 2) There were dramatic increases between birth and 7 days for Apo B and did not change between 7 days and 1 month, while Apo A-I was already present in significant levels at birth and was changed continuously between 7 days and 1 month. 3) There were marked increases between birth and 7 days for total cholesterol and triglycerides, while after 7 days the cholesterol levels only progressively increased until month. 4) There were continuous increases between birth and 7 days and 1 month for HDL-C, while LDL-C was markedly increased between birth and 7 days. 5) There were no significant correlations between serum Lp(a)concentrations and other lipid profiles neither age, sex and feeding formulas. In conclusion, our data suggest that the adequate timing for the screening test of Lp(a) in newborns is around 1 month after birth and there are no statistically significant correlations between Lp(a) and other lipid profiles.
Apolipoprotein A-I
;
Apolipoproteins B
;
Cholesterol
;
Cholesterol, HDL
;
Coronary Disease
;
Enzyme-Linked Immunosorbent Assay
;
Humans
;
Infant, Newborn*
;
Lipoprotein(a)*
;
Lipoproteins
;
Mass Screening
;
Parturition
;
Plasma
;
Risk Factors
;
Triglycerides
7.Mandibular Fracture Masking Hyoid Bone Fracture.
Moon Kyun CHO ; Je Min AN ; Chul Han KIM ; Sang Gue KANG
Archives of Plastic Surgery 2014;41(1):93-95
No abstract available.
Hyoid Bone*
;
Mandibular Fractures*
;
Masks*
8.The Treatment Of Fistula-in-ano in Infants.
Hang Jnn CHO ; Toung Kyun KIM ; Do Sun KIM ; Doo Han LEE ; Yoon Sik KANG
Journal of the Korean Society of Coloproctology 1997;13(1):97-100
The authors performed a retrospective review to find out optimal treatment plan in infantile fistula-in-ano. There were seventy-one patients in a 2-year period. All were male and other clinical characteristics were similar to previous reports. The onset in 60 patients(97%) of the cases was in the first 1 year of alee, especially in the first 3 months(52%). We investigated patterns of disease progression in multiple-lesion cases(19cases 29%). In 5 out of 9 cases of which we could identify the patterns, new lesion developed from 1 month to 4 months after index lesion. Fifty Patients underwent fistulotomy under principle of early surgical intervention, No recurrence was found except 2cases who needed second operation during 30 months of median follow-up(23~48 months). In 21 patients whose parents did not want operation, we performed simple drainage and followed-up. Six out of 12 patients who could be communicable had no fistula-related symptoms from 20 months to 31 months. This suggests that simple drainage has therapeutic effect in some portion of infantile abscess. We conclude that simple drainage should be initial treatment of choice in infantile perianal abscess. We suggest that definite operation for recurrent abscess and fistula with relatively mild symptoms should be delayed until 1-year of age because of interval ccurrence of multiple lesions and therapeutic effect of simple drainage.
Abscess
;
Child
;
Disease Progression
;
Drainage
;
Fistula
;
Humans
;
Infant*
;
Male
;
Parents
;
Rectal Fistula
;
Recurrence
;
Retrospective Studies
9.Vitreous Vascular Endothelial Growth Factor Concentration In Various Vitreoretinal Disorders.
Journal of the Korean Ophthalmological Society 2002;43(1):96-103
PURPOSE: Vascular endothelial growth factor (VEGF) has been identified as an endothelial cell-specific angiogenic factor of intraocular neovascularization, a pathologic complication of many vitreoretinal disorders. We studied to evaluate clinical correlation of intravitreal VEGF concentration and various vitreoretinal disorders. METHODS: Forty eight vitreous fluid samples were obtained at the time of vitreoretinal surgery from 43 patients of various disorders. Concentrations of VEGF1 6 5 in vitreous fluid were determined by Human VEGF ELISA kit and its correlation with diabetes, intraocular hemorrhage, neovascularization, proliferative vitreoretinopathy, retinal detachment, pan retinal photocoagulation, and postoperative condition was statistically analyzed. RESULTS: Intravitreal concentrations of VEGF in case of intraocular hemorrhage (0.809+/-1.467 ng/ml), neovascularization (1.167+/-1.656 ng/ml), and anterior segment neovascularization (2.381+/-2.043 ng/ml) were significantly high (P<0.05). CONCLUSIONS: VEGF plays a major role in the development of neovascularization in the various retinal disorders.
Angiogenesis Inducing Agents
;
Enzyme-Linked Immunosorbent Assay
;
Hemorrhage
;
Humans
;
Light Coagulation
;
Retinal Detachment
;
Retinaldehyde
;
Vascular Endothelial Growth Factor A*
;
Vitreoretinal Surgery
;
Vitreoretinopathy, Proliferative
10.A Case of Cystine Stone in a Child.
Chan Hong CHO ; Kong Sik HAHM ; Joo Kyun PARK ; Kyu Hwan KIM
Korean Journal of Urology 1986;27(6):933-938
Cystinuria is an autosomal recessive inherited defect in renal tubular reabsorption of four amino acids, cystine, ornithine, lysine and arginine. Homozygotes were identified by the formation of urinary tract calculi composed of cystine and by gross hyperexcretion of above mentioned four amino acids. Urinary tract calculi composed primarily of cystine are rare in adults and children. These are usually pure and found exclusively in patients with cystinuria. Herein we report on a 4 and 3/12 years old male child with a right renal stone composed primarily of cystine which was confirmed by chemical analysis method postoperatively. After discharge he has been treated with D-penicillamine, large fluid intake and conversion of urine pH.
Adult
;
Amino Acids
;
Arginine
;
Calculi
;
Child*
;
Cystine*
;
Cystinuria
;
Homozygote
;
Humans
;
Hydrogen-Ion Concentration
;
Lysine
;
Male
;
Ornithine
;
Penicillamine
;
Urinary Tract