1.The Unstable Intertrochanteric Fractures of Femur Treated with Sliding Compression Hip Screw: The Comparison between Anatomical Reduction and Non-Anatomical Reduction Groups
Hyung Ku YOON ; Kuk Han OH ; Kyung Hun KANG ; Jin Ill KIM ; Min Ho PARK
The Journal of the Korean Orthopaedic Association 1996;31(2):225-234
Due to the instability of intertrochanteric fractures in elderly patients, various methods of reduction and fixation were introduced to obtain stable reduction and solid union, But there have been many controversies regarding advantages between anatomical reduction group and non-anatomical reduction group. The authors analyzed the 68 unstable intertrochanteric fractures out of total 94 cases of intertrochanteric fractures treated from Jan. 1988 to Jan. 1994 with mean follow-up 17 months and evaluated the radiologic and clinical results between those two groups. The results were obtained as follows: 1. The most common cause was low energy injury and according to the Tronzo classification, the type III was most common in 54 cases (79.4%). 2. The average union time was 14.0wks (84%), the union rate was low in the medialized reduction group(A-P) and anterior displaced reduction group(A-P), anterior displaced and anatomical reduction groups(Lateral). 3. The compression length more than 10mm of lag screw was deep in medialized reduction group(A-P), another displaced and anatomical reduction groups(Lateral). 4. The average length of lag screw sliding was 9.2mm and depth sliding of 6.8mm (74%) was occurred within immediate postoperative 1 month.
Aged
;
Classification
;
Femur
;
Follow-Up Studies
;
Hip Fractures
;
Hip
;
Humans
2.Presence of a Nail in the Medullary Canal; Is It Enough to Prevent Femoral Neck Shortening in Trochanteric Fracture?.
Hyung Keun SONG ; Han Kuk YOON ; Kyu Hyun YANG
Yonsei Medical Journal 2014;55(5):1400-1405
PURPOSE: Presence of a cephalomedullary nail (CMN) in the medullary canal has been thought as advantageous in the control of femoral neck shortening (FNS) and lag screw sliding in trochanteric fracture compared to extramedullary fixation system. However, researches on the factors that influence the degree of FNS after cephalomedullary nailing are lacking. MATERIALS AND METHODS: We observed 95 patients (mean age, 75+/-2.8 years) with trochanteric fractures who were treated with a CMN, and evaluated the relationship between FNS and patient factors including age, gender, fracture type (AO/OTA), bone mineral density, medullary canal diameter, canal occupancy ratio (COR=nail size/canal diameter), and tip-apex distance using initial, immediate postoperative, and follow-up radiography. RESULTS: Univariate regression analyses revealed that the degree of FNS was significantly correlated with fracture type (A1 versus A3, p<0.001), medullary canal diameter (p<0.001), and COR (p<0.001). Multiple regression analyses revealed that FNS was strongly correlated with fracture type (p<0.001) and COR (p<0.001). CONCLUSION: Presence of a CMN in the medullary canal could not effectively prevent FNS in patients with low COR and in A3 type fracture.
Aged
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*Bone Nails
;
Female
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Femur Neck/*radiography
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Hip Fractures/radiography/*surgery
;
Humans
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Male
;
Orthopedic Procedures/*methods
;
Regression Analysis
3.Availability of treatment of congenital calcaneovalgus.
Hyung Ku YOON ; Kwang Pyo JEON ; Kuk Whan OH ; Dae Eun JUNG ; Dong Jun KIM ; Han Lim KIM
The Journal of the Korean Orthopaedic Association 1992;27(7):1674-1681
No abstract available.
4.A clinical study of ender-nailing for segmental fracture of tibia.
Hyung Ku YOON ; Kwang Pyo JEON ; Kuk Hwan OH ; Dong Jun KIM ; Dae Eun JUNG ; Sang Kyu HAN
The Journal of the Korean Orthopaedic Association 1991;26(6):1660-1666
No abstract available.
Tibia*
5.A Clinical Significance of Ultrasonography in Transient Synovitis of the Hip
Hyung Ku YOON ; Kwang Pyo JEON ; Kuk Hwan OH ; Dong Jun KIM ; Kyung Su CHA ; Sang Kyu HAN
The Journal of the Korean Orthopaedic Association 1990;25(6):1644-1650
Transient synovitis of the hip is non-specific inflammation and self limited condition, which is most common cause of painful limping in children under 10 years of age. Ultrasonography presents some merits, simple, rapid, non-invasive, low cost, repetitive to assess soft structures in and around the hip joint compared to other diagnostic methods. We prospectively studied 32 cases of unilateral transient synovitis at OPD from Jan. 1988 to Oct. 1989 using 5-7.5 MH, probe ultrasonography. 2-times serial check up in symptomatic and asymptomatic stage about capsule thickness and bone-capsule distance in 3 different positions of the both hips were performed for comparision. The following results were obtained; 1. Boys were 25 cases (78%) and 26 cases (83%) were between 3 and 7 years old of age. 2. Bone-capsule distance in ultrasonography revealed abnormal increase in 72%. 3. External rotation position showed wider bone-capsule distance than other position. 4. Capsule thickness was 3.3mm in diseased and 3.0mm in sound, 0.3mm decrease after treatment. 5. Bone-capsule distance was 4.5mm in symptomatic stage, 2.7mm in asymptomatic stage, 1.8mm decrease after treatment in averge.
Child
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Hip Joint
;
Hip
;
Humans
;
Inflammation
;
Prospective Studies
;
Synovitis
;
Ultrasonography
6.Immunohistochemical Study on the Expression of Topoisomerase II alpha and Glutathione S-Transferase pi in Acute Myeloid Leukemia.
Byoung Kuk KIM ; Yoon Sung JEONG ; Chul Hun CHANG ; Han Chul SON ; Soon Ho KIM ; Mee Young SOL ; Eun Yup LEE
Korean Journal of Clinical Pathology 1998;18(2):107-114
BACKGROUND: Topoisomerase II (topo II) is a major target of anthracyclines and epipodophyllotoxins for anticancer treatment. The expression of topo II is low in drug resistant cell lines. High levels of glutathione S-transferase (GST)pi have been associated with emergence of cell lines resistant to alkylating agents or adriamycin. METHODS: By immunostaining with paraffin embedded bone marrow tissues, the expression of topo II alpha and GSTpi was investigated in 51 patients with acute myeloid leukemia (AML), and the relation of topo II alpha and GSTpi expression to treatment response in 29 patients with AML following induction chemotherapy was also evaluated. RESULTS: Topo II positive cells varied from less than 1% to 60% of leukemic cells and 20 (39.2%) were negative for topo II (positive cells<10%). Treatment response following chemotherapy was not related to topo II. 26 (51.0%) were positive for GSTpi. GSTpi expression was related to treatment resistance of the patients following chemotherapy. In the patients who showed both topo II alpha negative and GSTpi positive, the frequency of treatment resistance following chemotherapy was high. CONCLUSIONS: This study suggests that immunostaining of topo II alpha and GSTpi with the bone marrow paraffin sections of AML patients can be useful to predict the treatment response following chemotherapy and that further study including more patients with prospective study may substantiate topo II alpha and GSTpi as multidrug resistant markers.
Alkylating Agents
;
Anthracyclines
;
Bone Marrow
;
Cell Line
;
DNA Topoisomerases, Type II*
;
Doxorubicin
;
Drug Resistance, Multiple
;
Drug Therapy
;
Glutathione S-Transferase pi*
;
Glutathione Transferase*
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Glutathione*
;
Humans
;
Immunohistochemistry
;
Induction Chemotherapy
;
Leukemia, Myeloid, Acute*
;
Paraffin
;
Podophyllotoxin
7.The association between Staphylococcus aureus colonization and food sensitization in children with atopic dermatitis.
Yoon Ha HWANG ; Song Han LEE ; Byoung Kuk KIM ; Sung Won KIM
Allergy, Asthma & Respiratory Disease 2017;5(4):193-199
PURPOSE: Atopic dermatitis is often accompanied by food allergies which occur through skin barrier defects. Especially Staphylococcus aureus colonization can exacerbate skin barrier defects that cause sensitization and increase specific IgE (sIgE) to food. We investigated the association between skin colonization and food sIgE changes in children with atopic dermatitis. METHODS: Atopic dermatitis was diagnosed by a pediatric allergist in patients between 3 months and 3 years of age. Total IgE and sIgE to egg white, cow's milk, wheat, and peanuts were taken. Eosinophil count and eosinophil cationic protein were also taken. Comparisons were done between the groups with and without S. aureus colonization. RESULTS: It was found that 50.3% of the 294 enrolled patients had S. aureus colonization on lesional skin. Statistically significant sensitization to wheat and peanut were increased with S. aureus colonization. Statistically significant increases in sIgE (above cutoff level) were also found in egg white, milk, wheat and peanut. Higher S. aureus colony counts also increased sIgE of all foods. Methicillin-resistant S. aureus showed no statistical difference compared to methicillin-susceptible S. aureus in severity and sIgE levels. CONCLUSION: S. aureus colonization increases the risk of food sensitization in children with atopic dermatitis.
Arachis
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Child*
;
Colon*
;
Dermatitis, Atopic*
;
Egg White
;
Eosinophil Cationic Protein
;
Eosinophils
;
Food Hypersensitivity
;
Humans
;
Immunoglobulin E
;
Methicillin Resistance
;
Milk
;
Skin
;
Staphylococcus aureus*
;
Staphylococcus*
;
Triticum
8.Anti-Tumor Effect of AG60 against Ehrlich Tumor.
Kyung Yung LEE ; Bo Im YOO ; Jun Sang YOON ; Young Shin CHUNG ; Young Bok HAN
Journal of the Korean Surgical Society 1998;54(6):765-771
BACKGROUND: AG60 is a complex of acriflavine and guanosine. Our previous study revealed that AG60 had not only in vitro antitumor activities in several human cancer cell lines, but also strong antitumor effects in animal experiments using p388 or S180 cells-implanted mice. METHODS: Antitumor effects of AG60 were compared with those of Adriamycin, acriflavine, guanosine or control group. Body weight, tumor weight change, and survival time were measured in Ehrlich carcinoma cells implanted ICR mice. RESULTS: Body weights in AG60, acriflavine, or Adriamycin treated groups were significantly lower than those in control group during 30 day observation period(p<0.05). The percent tumor growth inhibition of AG60, Adriamycin, acriflavine, or guanosine two weeks after last treatment was respectively 86% (T/C%=14), 83% (T/C%=17), 68%(T/C%=32), 41% (T/C%=59). According to above data, tumor growth inhibition in AG60 treated group was significantly stronger than that in control, acriflavine or guanosine treated group(p<0.01), but there was no significant difference between AG60 and Adriamycin treated group. Mean survival time in control, AG60, Adriamycin, acriflavine, or guanosine treated group was respectively 33+/-3.9 days, 68+/-4.2 days, 54+/-5.8 days, 36+/-3.8 days, 50+/-8.1 days. CONCLUSIONS: The anti-tumor effect of AG60 against Ehrlich tumor was significantly stronger than that of control, acriflavine or guanosine, and comparable with Adriamycin. Mean survival time in AG60 treated group was significantly longer than that in control, acrifavine, guanosine or Adriamysin treated group.
Acriflavine
;
Animal Experimentation
;
Animals
;
Body Weight
;
Cell Line
;
Doxorubicin
;
Guanosine
;
Humans
;
Mice
;
Mice, Inbred ICR
;
Survival Rate
;
Tumor Burden
9.Clinical Significance of Serum Leptin Level in Adolescent Patients with Menstrual Abnormalities.
Kuk Sun HAN ; Byung Koo YOON ; Je Ho LEE ; Doo Seok CHOI
Korean Journal of Obstetrics and Gynecology 2001;44(6):1078-1083
OBJECTIVES: Leptin is known as an endocrinologic mediator which acts on the hypothalamic- pituitary-ovarian axis. This study was undertaken to evaluate whether the serum leptin level affects the menstrual cycles of adolescents and to analyze the clinical features of adolescents with abnormal serum leptin levels. METHODS: Seventeen normal controls and 118 patients with menstrual abnormalities were included in this study. The ages of patients ranged from 15 to 25 years. Patients with menstrual abnormality were divided into five subgroups according to the etiologies: group I; premature ovarian failure(n=8), group II; primary amenorrhea without congenital structural abnormality(n=14), group III; oligomenorrhea(n=12), group IV; secondary amenorrhea(n=53), group V; dysfunctional uterine bleeding(n=31). After collection of blood samples, the serum leptin levels were measured with a radioimmunoassay kit. The serum leptin level and the corrected leptin level(leptin/body mass index(BMI)) were compared and the clinical features of those with abnormal leptin concentration (>mean+standard deviation,
10.A case of tuberculosis occurred on the graft kidney.
Eung Hoon IM ; Sang Kuk HAN ; Il Gun JUNG ; Seok Ju AHN ; Young Suk YOON ; Byung Kee BANG ; Yong Bok KOH
The Journal of the Korean Society for Transplantation 1991;5(1):129-133
No abstract available.
Kidney*
;
Transplants*
;
Tuberculosis*