1.A Cytogenetic Study of Amenorrhea.
Kyung Soon LEE ; Jung Ho HAN ; Shin Yong MOON
Korean Journal of Fertility and Sterility 1999;26(3):467-474
OBJECTIVEs: Cytogenetic investigations were carried out on 770 women with primary (n=560) and secondary amenorrhea (n=210) to determine the frequency of chromosomal or genetic causes of amenorrhea. MATERIALS AND METHODS: In 770 women with primary amenorrhea (n=560) and secondary amenorrhea (n=210), chromosomal analysis were performed. RESULTS: 1) The most prevalent age group is 16-20 years of age group with primary amenorrhea and 26-30 years of age group with secondary amenorrhea. 2) Out of 560 cases of primary amenorrhea, 343 cases (61.3%) had the normal chromosome constitution and 217 cases (38.7%) had the abnormal chromosome constitution including 46,XY. 3) In 217 cases of abnormal chromosome of primary amenorrhea, 57 cases (26.3%) had 45,X and 34 cases (15.8%) had the 46,XY, 24 cases (11.0%) had 45,X/46,X,i (Xq), 23 cases (10.6%) had 45,X/46,X,+mar and 14 cases (6.6%) had 45,X/46,XY. 4) Out of 210 cases of secondary amenorrhea, 181 cases (86.2%) had the normal chromosome constitution and 29 cases (13.8%) had 45,X/46,XX. CONCLUSION: High percentage of chromosomal abnormalities was diagnosed in primary amenorrhea and most of them were sex chromosome anomalies. In secondary amenorrhea, the prevalence was lower than primary amenorrhea, so a preselection of patients with secondary amenorrhea for cytogenetic investigations seems to be necessary.
Amenorrhea*
;
Chromosome Aberrations
;
Constitution and Bylaws
;
Cytogenetics*
;
Female
;
Humans
;
Prevalence
;
Sex Chromosomes
2.Clinical observation on resectable cases after preoperative radiation therapy in initially unresectable rectal cancer.
Ho Se HAN ; Yong Shin KIM ; Kwang Yun KIM
Journal of the Korean Surgical Society 1992;43(4):560-566
No abstract available.
Rectal Neoplasms*
3.The Predictive Factors for Central Nervous System Lesion in Central Precocious Puberty and the Utility of Single Timed LH after GnRH Administration.
Jin Ho CHOI ; Young Lim SHIN ; Han Wook YOO
Journal of Korean Society of Pediatric Endocrinology 2002;7(2):206-214
PURPOSE: This study was undertaken to determine whether the clinical presentation of patients with central precocius puberty(CPP) varies according to the etiology, whether this permits the differentiation between idiopathic and organic forms and to examine whether LH determination in a single timed blood sample after GnRH administration is sufficient to diagnose CPP. METHODS: This study included 33 girls with signs of breast development, of whom 23 were diagnosed as definite central precocious puberty. Sixteen patients had idiopathic CPP; the remaining 7 patients had organic CPP. Ten patients were classified as non-CPP. Potential clinical and laboratory predictors of CNS abnormalities were assessed and GnRH stimulation test was done. RESULTS: The age of onset in patients with organic CPP was 4.11+/-2.08 years, whereas the age in patients with idiopathic CPP was 7.25+/-1.34 years. This parameter is the only one showing statistical significance. We compared sensitivities and specificities at 0, 15, 30, 60, 90 and 120 min which yielded sensitivities of 8.7%, 87.0%, 91.3%, 87.0%, 73.9%, 60.9%. CONCLUSION: It is impossible to exclude a central nervous system lesion in patient with central precocious puberty without performing central nervous system imaging. However, this study indicates earlier the onset of disease, higher the possibility of presence of CNS lesion. According to the mean GnRH stimulated LH levels and sensitivity at each times, a single blood sample obtained for LH determined after GnRH administration at 30 min can be used to diagnose the central precocious puberty.
Age of Onset
;
Breast
;
Central Nervous System*
;
Female
;
Gonadotropin-Releasing Hormone*
;
Humans
;
Luteinizing Hormone
;
Puberty, Precocious*
4.A Case of Solitary Fibrofolliculoma.
Kyu Han KIM ; Jee Ho CHOI ; Yoo Shin LEE
Korean Journal of Dermatology 1984;22(6):672-674
The fibrofolliculoma is characterized by abnormal hair follicles with epithelial strands extending out from the infundibulum of the hair follicle into a hyperplastic mantle of specialized fibrous tissue. We have seen a peculiar case of a 1 year and 2 months old male who had a solitary papule on the left side of his face which histologically showed a typical fibrofolliculoma pattern.
Hair Follicle
;
Humans
;
Infant
;
Male
5.Calcaneus Fractures: Clinical Study of Axial Fixation
Kwon Ick HA ; Sung Ho HAN ; Dong Shik SHIN
The Journal of the Korean Orthopaedic Association 1982;17(4):704-709
There is a great difference of opinion regarding the treatment of intraarticular fractures of the calcaneus. Many authors suggested that there are essentially four basic methods of treatment, but the choice of treatment depends on the surgeons preference, the type of fracture, and the age of the patient. We obtained the following results in 11 cases of calcaneal fractures involving subtalar joint which were treated by axial fixation at our hospital from 1977 to 1981. 1. The favourable results were obtained in 5 cases of 6 feet of tongue type fractures and in 3 cases of 5 feet of joint depression fractures. 2. Even if the joint depression type fracture which is not severely comminuted, the treatment with axial fixation is thought to be good method. 3. Axial fixation must be tried in three faces of reduction which are reestablishment of Bohler angle and subtalar joint and reduction of lateral bulging of calcaneus. The results were more excellent in which reduction is achieved near anatomical position.
Calcaneus
;
Clinical Study
;
Depression
;
Foot
;
Humans
;
Intra-Articular Fractures
;
Joints
;
Methods
;
Subtalar Joint
;
Surgeons
;
Tongue
6.A Clinical Study on the Supracondylar Fractures of the Femur
Kyoo Ho SHIN ; Dae Yong HAN ; Byung Moon PARK
The Journal of the Korean Orthopaedic Association 1983;18(2):322-334
The management of supracondylar fractures of the femur remains controversial. Most studies over the past twenty years have attempted to compare the results of non-surgical with those of surgical methods. Until a few years ago, conservative treatment was considered superior to internal fixation of supracondylar fractures of the femur. However, the development of new fixation devices and techniques have, according to several investigations, improved the results of the treatment of these fractures. The following clinical results were shown by analysis of 96 cases of supracondylar fractures of the femur treated in the Department of Orthopedic Surgery, Yonsei University, College of Medicine during the past 10 years from Jan. 1971 to Dec. 1980. 1. The prevalent age distribution was between 21 and 50 years of age (79.1%), and the ratio between males and females was 3.4:1. The most common cause of injury was car accidents (51.0%). 2. A classification of supracondylar fractures was unicondylar, simple supracondylar and intercondylar. Intercondylar which was subdivided into Type I, II-A, II-B, III according to Neer's classification. 3. Fifty nine patients (61.4%) were associated with injuries of other parts and the most frequent associated fracture was tibial fracture and the most common associated soft tissue injury was cerebral concussion or contusion. 4. The methods of treatment: conservative management by using skeletal traction for 34 cases, surgical treatment by open reduction and internal fixation for 58 cases and A-K amputation for 4 cases due to populiteral artery injury. 5. Fifty nine cases were suitable for result analysis. The satisfactory result of surgical treatment was 63.4% and conservative treatment was 50.0% respectively. The factors affecting the final results were Type of fracture, severity of injury, and rigid internal fixation. 6. The main complications of the supracondylar fractures of the femur were delayed union (10.2%), infection (10.2%), and traumatic arthritis (13.3%). 7. Finally, the results of treatment depend largely on anatomical reduction, rigid fixation, early joint motion.
Age Distribution
;
Amputation
;
Arteries
;
Arthritis
;
Brain Concussion
;
Classification
;
Clinical Study
;
Contusions
;
Female
;
Femur
;
Humans
;
Joints
;
Male
;
Orthopedics
;
Soft Tissue Injuries
;
Tibial Fractures
;
Traction
7.A case of human thelaziasis in Seoul.
Won Young CHOI ; Won Koo LEE ; Ok Ran LEE ; Han Ho SHIN ; Ne Yong SHIN
The Korean Journal of Parasitology 1977;15(2):127-132
Thelazia callipaeda, parasitic in the eye of 24 years old Korean male, was extracted from the left eye of the patient in Seoul, Korea. We confirmed that as T. callipeada morphologically, based on the descriptions of Hsu and other literature. We presents the 7th human thelaziasis case in Korea with the historical review of the literature.
parasitology-helminth-nematoda
;
Thelazia callipaeda
;
thelaziasis
;
case report
8.The Ocular Parasitic Inflammations due to Cysticercus Larva.
Kwang Il KOO ; Han Ho SHIN ; Ne Yong SHIN
Journal of the Korean Ophthalmological Society 1976;17(1):111-115
Localized subconjunctival abscess, episcleritis, recurrent lid abscess, and chorioretinitis are not uncommon diseases of the eye due to various causes such as infective emboli, buried cilia, trauma, autoimmune reactions, or specific infection. The cysticercus cellu]osae has been found in all parts of the eye and the lid, but there are less common presentation of the infection foci than of the cysticercus cellulosae alone. A subconjunctival abscess which is located in the upper fornix of the right eye near the caruncle, episcleritis which is localized in the upper half of the conjunctiva of the left eye, a recurrent abscess of the lid which is located in the right lower lid, a chorioretinitis which is not good visualization because of many cells and flares in the vitreous body, are reported due to a cysticercus larva. No systemic manifestation of cysticercus is found at all. The literature for ocular cysticercosis is referred.
Abscess
;
Chorioretinitis
;
Cilia
;
Conjunctiva
;
Cysticercosis
;
Cysticercus*
;
Inflammation*
;
Larva*
;
Scleritis
;
Vitreous Body
9.Microphthalmos with Large Cyst and Colobomatous Microphthalmos in the Other Eye.
Jae Ho LEE ; Seung Wan SHIN ; Han Ho SHIN
Journal of the Korean Ophthalmological Society 1993;34(12):1203-1207
Microphthalmos is a uncommon congenital ocular anomaly and the term is justified in that in all cases the eyes are smaller than normal. Microphthalmos is classified as various forms according to degrees of developmental abnormality. The authors experienced a case of microphthalmos with a large cyst in one eye and colobomatous microphthalmos in the other eye.
Coloboma
;
Microphthalmos*
10.A Case of Modified Jensen Procedure in 6th Nerve Palsy.
Journal of the Korean Ophthalmological Society 1982;23(3):829-833
Because of the long intracranial course, the 6th nerve is vulnerable to increased intracranial pressure, trauma to the cranial floor, meningeal edema, inflammation in the base of the skull, and any displacement of the brain stem. The authors had experienced a case of abducens nerve palsy resulting non-concomittent esotropia and lateral gaze palsy due to brain trauma by traffic accident. We had performed modified Jensen procedure that had good result. That procedure is presented to aid in preserving the anterior segment blood supply. The anterior ciliary artery in the lateral rectus is not included in the union. The case report is reviewed with the pertinent literature.
Abducens Nerve Diseases*
;
Accidents, Traffic
;
Brain Injuries
;
Brain Stem
;
Ciliary Arteries
;
Edema
;
Esotropia
;
Inflammation
;
Intracranial Pressure
;
Paralysis
;
Skull